LEADING ANTENATAL FACTORS OF CONGENITAL PNEUMONIA IN PREMATURE NEWBORNS WITH VITAMIN D DEFICIENCY
Relevance: The incidence of congenital pneumonia varies about 1% among full-term newborns, and in premature infants up to 10%. From 10 to 40% of cases occupy a leading place in the structure of neonatal mortality [1,2]. Nissen M.D. [13], described that pneumonia was the cause of about 1.2 million neonatal deaths per year worldwide [9]. The role of vitamin D in the functioning and regulation of the immune system is important, since 1,25-dihydroxyvitamin D can contribute to an innate immature response to a pathogen [6]. Some studies have revealed a link between respiratory infectious diseases and vitamin D deficiency in serum in children [18,14].
Objective: To assess risk factors and the level of vitamin D in the blood serum of premature newborns with congenital pneumonia.
Materials and methods: case - control. The study was conducted on the basis of the Regional Perinatal Center of Semey, Republic of Kazakhstan. The study included premature newborns in the number of 228 children. Informational consents were received from mothers of newborns to participate in the study. The mothers were informed about the processing of the received data, with the subsequent publication of the research results, without specifying personal data. Inclusion criteria: premature newborns (gestation period from 22 weeks to 37 weeks). Exclusion criteria: children with malformations, genetic diseases, full-term newborns. The data analysis was carried out using the SPSS package version 20.0. To check the statistical significance of the differences between the group of "cases" and "controls", the Pearson criterion χ2 is used, and the odds ratio is calculated taking into account the 95% confidence interval. Continuous data is presented in the form of (M) and standard deviation (CO).
Results: The leading risk factors for congenital pneumonia in premature newborns were: infections of the mother, such as acute respiratory viral infections, pathology of the urinary system, premature discharge of amniotic fluid (18 hours), chorioamnionitis, preeclampsia, placental abruption led to a threatening fetal condition and premature birth.
Conclusion: Leading antenatal factors and vitamin D deficiency in premature newborns may be associated with a higher risk of developing congenital pneumonia.
Gulnarа B. Taiorazova1, https://orcid.org/0000-0002-8450-9204
Aliya R. Alimbaeva1, https://orcid.org/0000-0002-5082-4636
Sayat Z. Tanatarov1, https://orcid.org/0000-0001-8958-8768
Zhanargul K. Smailova1, https://orcid.org/0000-0002-4513-4614
Yuri F. Lobanov2, https://orcid.org/0000-0001-6284-1604
Nazym М. Ailbayeva1, https://orcid.org/0000-0003-1700-9696
Duman Berikuly1, https://orcid.org/0000-0002-9738-7453
Dinara О. Ahmetzhanova1, https://orcid.org/0000-0003-0000-2535
Danara Imanmadiyeva1, https://orcid.org/0000-0002-7772-9727
1 NJSC «Semey Medical University», Semey, Republic of Kazakhstan;
2 Altai State Medical University, Barnaul, Russian Federation.
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Taiorazova G.B., Alimbaeva A.R., Tanatarov S.Z., Smailova Zh.K., Lobanov Yu.F., Ailbayeva N.М., Berikuly D., Ahmetzhanova D.О., Imanmadiyeva D. Leading antenatal factors of congenital pneumonia in premature newborns with vitamin D deficiency // Nauka i Zdravookhranenie [Science & Healthcare]. 2022, (Vol.24) 6, pp. 71-77. doi 10.34689/SH.2022.24.6.010Похожие публикации:
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