THE ROLE OF VITAMINE D IN THE CLINIC OF CHRONIC KIDNEY DISEASE IN CHILDREN
Introduction. Knowledge of risk factors, progression mechanisms, and early predictors of chronic kidney disease (CKD) in children will help prevent the development of распишите аббревиатуру (ESRD) and forms the basis of a nephroprotective strategy.
The aim: To determine the frequency of vit D deficiency in children with kidney pathology and to substantiate the role of vit D in the prediction and progression of CKD in children.
Materials and methods: Clinical observational Case-Control study, the case group included 36 children from 0 to 17 years old inclusive with a diagnosis of chronic kidney disease (CKD), vitamin D disadvantage, who received treatment in the nephrology department of the Regional Children's Clinical Hospital. The control group included 54 children from 0 to 17 years old inclusive with a diagnosis of CКD with vitamin D disadvantage and \or with normal vitamin D content.
Results: n the case group, a naturally strong inverse relationship between vit D levels and arterial hypertension, sweating, irritability, edema, fatigue, and decreased appetite revealed. Correlation analysis showed an inverse relationship of average strength between vit D levels and laboratory indicators such as proteinuriа, urinаry syndromе, there is an inverse relationship of weak strength between vit D levels and сoncomitant diseases.
Conclusions: The main causes of the development of chronic kidney disease in children have been identified: UTI is complicated by urinary syndromе - 59%, congenital malformations - 24%, glomerulаr diseases - 17%. Significant features of the clinical course were determined: arterial hypotension syndrome - 32%; arterial hypertension syndrome – 3O.1%; left ventricular hypertrophy - 38.2%; anemia - 50.7%; increased uric acid in the blood - 38.4%; secondary hyperparathyroidism - 41.1%. In children of the main group, there is a strong direct relationship betwixt the level of vit D and GFR, vit D levels and the stage of CKD.
Sandugash B. Dyussenova1, https://orsid.org/0000-0001-9667-0735
Gulmira A. Sarmankulova1, https://orsid.org/0000-0001-6393-5944
Makpal M. Sabiyeva1, https://orsid.org/0000-0003-2322-400X
Kanipa S. Tlegenova1, https://orsid.org/0000-0003-0759-7068
Veronika V. Kurilova1, https://orsid.org/0000-0002-8278-0789
Medical University of Karaganda, Karaganda, Republic of Kazakhstan.
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Dyussenova S.B., Sarmankulova G.A., Sabiyeva M.M., Tlegenova K.S., Kurilova V.V. The role of vitamine D in the clinic of chronic kidney disease in children // Nauka i Zdravookhranenie [Science & Healthcare]. 2023, (Vol.25) 4, pp. 109-117. doi 10.34689/SH.2023.25.4.013Похожие публикации:
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