THE ASSOCIATION OF RS11781551 AND RS6988985 WITH HYPERTENSION IN THE GROUP OF KAZAKH INDIVIDUALS
Background. Arterial hypertension (HT) is a leading risk factor for mortality and morbidity especially in the developing countries. Kazakhstan is not an exception, the first reason of death is cardiovascular diseases which are directly associated with high blood pressure. Among risk factors, the genetic ones are the least understood, so the aim of current study is to find association of some SNPs of eighth chromosome and HT in the group of Kazakh individuals.
Materials and Methods. A total of 606 Kazakh patients were recruited, 394 of them were diagnosed with HT, the remaining 212 were in the control group, i.e. did not have HT. The genotyping was performed using the Open Array technology. The SNPs and phenotype association assessment was taken in pairs of the HT- and HT+ groups, following the case-control design based on a GLM. The genotype and phenotype signs association was esteemed using 4 inheritance models: dominant, co-dominant, recessive, and log-additive inheritance models.
Results. It was found that the rs11781551 in codominant study model (OR 0.370 [0.157-0.871]) and in the dominant study model (OR 0.370 [0.157-0.871]) was associated with the presence of HT.
There is the significant association of rs6988985 and HT in studied population in codominant (for C/T genotype OR = 0.567 [0.336-0.956], for T/T genotype OR = 0.422 [0.224-0.795]), recessive (OR = 0.522 [0.316-0.861]) and log-additive models (OR = 0.648 [0.473-0.887]). These associations were found after the adjustments for gender and age, BMI, gender, glucose, total cholesterol, LDL, HDL and triglycerides.
Discussion. In the current analysis, it was found that two polymorphisms rs11781551 and rs6988985 significantly affected the presence of hypertension, regardless of age, gender, BMI, glucose level and lipid profile in the group of Kazakh individuals. These findings may have implications for the development of personalized approaches to the prevention and treatment of HT.
Valeriy Benberin1,2, http://orcid.org//0000-0003-2422-4853
Raushan Karabayeva1,2, http://orcid.org//0000-0003-2945-8122
Zhanatgul Turgumbayeva1, http://orcid.org//0009-0002-6814-4775
Alisher Aitkaliyev1, http://orcid.org//0009-0002-9624-2663
Ainur Sibagatova*1,2, http://orcid.org//0000-0001-6399-3810
1 Medical Centre Hospital of President’s Affairs Administration of the Republic of Kazakhstan, Astana, Republic of Kazakhstan;
2 The Asfendiyarov Kazakh National Medical University, Almaty, Republic of Kazakhstan.
1. Beaney T., Schutte A.E., Stergiou G.S., Borghi C., Burger D., Charchar F. et al. May Measurement Month 2019: The Global Blood Pressure Screening Campaign of the International Society of Hypertension // Hypertension. 2020. 76(2):333-41.
2. Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017 // Lancet. 2018. 392(10159):1923-94.
3. Gheorghe A., Griffiths U., Murphy A., Legido-Quigley H., Lamptey P., Perel P. The economic burden of cardiovascular disease and hypertension in low-and middle-income countries: a systematic review // BMC Public Health. 2018.18(1):1-11.
4. Kazakhstan MoHotRo. State Program on Health Systems’ Development Salamatty Kazakhstan for the Years 2011–2015. Astana, Kazakhstan 2010. S. 9
5. MedInform Health of Population and Health Care in the Republic of Kazakhstan in 2013, Official Statistic [Internet]. [cited 16.03.2023]. www.medinfo.kz.
6. Yerdessov S., Kadyrzhanuly K., Sakko Y., Gusmanov A, Zhakhina G, Galiyeva D, et al. Epidemiology of Arterial Hypertension in Kazakhstan: Data fr om Unified Nationwide Electronic Healthcare System 2014-2019 // J Cardiovasc Dev Dis. 2022.9(2). S. 52
7. Jordan J., Kurschat C., Reuter H. Arterial Hypertension // Dtsch Arztebl Int. 2018;115(33-34):557-68.
8. Wang Y., Zhang J., Ding Y., Zhang M., Liu J., Ma J., et al. Prevalence of hypertension among adults in remote rural areas of Xinjiang, China // International journal of environmental research and public health. 2016. 13(6):524.
9. Kelly T.N., Sun X., He K.Y., Brown M.R., Taliun S.A.G., Hellwege J.N. et al. Insights From a Large-Scale Whole-Genome Sequencing Study of Systolic Blood Pressure, Diastolic Blood Pressure, and Hypertension // Hypertension. 2022. 79(8):1656-67.
10. Li Y., Zheng H., Yang J., Zhang B., Xing X., Zhang Z. et al. Association of genetic variants in Leptin, leptin receptor and adiponectin with hypertension risk and circulating Leptin / Adiponectin changes // Gene. 2023. 853:147080.
11. Gu D., Ge D., Snieder H., He J., Chen S., Huang J. et al. Association of alpha1A adrenergic receptor gene variants on chromosome 8p21 with human stage 2 hypertension // J Hypertens. 2006. 24(6):1049-56.
12. Yang W.J., Huang J.F., Yao C.L., Fan Z.J., Ge D.L., Gan W.Q. et al. Evidence for linkage and association of the markers near the LPL gene with hypertension in Chinese families // J Med Genet. 2003. 40(5):e57.
13. Newton-Cheh C., Johnson T., Gateva V., Tobin M.D., Bochud M., Coin L. et al. Genome-wide association study identifies eight loci associated with blood pressure // Nat Genet. 2009. 41(6):666-76.
14. Raushan K., Benberin V., Vochshenkova T., Babenko D., Sibagatova A. Association of 3 single nucleotide polymorphisms of the eighth chromosome with remodeling of the myocardium and carotid arteries in the Kazakh population // Medicine. 2021. 100(6). e24608
15. Lei S., Peng F., Li M.L., Duan W.B., Peng C.Q., Wu S.J. LncRNA-SMILR modulates RhoA/ROCK signaling by targeting miR-141 to regulate vascular remodeling in pulmonary arterial hypertension // Am J Physiol Heart Circ Physiol. 2020. 319(2):H377-h91.
16. Mahmoud A.D., Ballantyne M.D., Miscianinov V., Pinel K., Hung J., Scanlon J.P. et al. The Human-Specific and Smooth Muscle Cell-Enriched LncRNA SMILR Promotes Proliferation by Regulating Mitotic CENPF mRNA and Drives Cell-Cycle Progression Which Can Be Targeted to Lim it Vascular Remodeling // Circ Res. 2019. 125(5):535-51.
17. Ballantyne M.D., Pinel K., Dakin R., Vesey A.T., Diver L., Mackenzie R. et al. Smooth Muscle Enriched Long Noncoding RNA (SMILR) Regulates Cell Proliferation // Circulation. 2016. 133(21):2050-65.
18. Sadeghi M., Izadi A., Hadavi M.M., Fard M.R., Roohafza H. Comparison of the effect of 12- and 24-session cardiac rehabilitation on physical, psychosocial and biomedical factors in ischemic heart disease patients. Hormone Molecular Biology and Clinical Investigation. 2020. 41(1).20190023.
19. Malkin C.J., Pugh P.J., Morris P.D., Asif S., Jones T.H., Channer K.S. Low serum testosterone and increased mortality in men with coronary heart disease // Heart. 2010. 96(22):1821-5.
20. Mаrin P., Holmäng S., Gustafsson C., Jönsson L., Kvist H., Elander A. et al. Androgen treatment of abdominally obese men // Obes Res. 1993.1(4):245-51.
21. Corona G., Rastrelli G., Monami M., Guay A., Buvat J., Sforza A. et al. Hypogonadism as a risk factor for cardiovascular mortality in men: a meta-analytic study // Eur J Endocrinol. 2011. 165(5):687-701.
22. Mendelsohn M.E., Karas R.H. The protective effects of estrogen on the cardiovascular system // N Engl J Med. 1999. 340(23):1801-11.
23. Cheng X., Xu G. Association between aldosterone synthase CYP11B2 polymorphism and essential hypertension in Chinese: a meta-analysis // Kidney Blood Press Res. 2009. 32(2):128-40.
24. MedlinePlus: the National Library of Medicine (NIH): Accessed: 01.08.2023 https://medlineplus.gov/genetics/.
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Benberin V., Karabayeva R., Turgumbayeva Zh., Aitkaliyev A., Sibagatova A. The association of RS11781551 and RS6988985 with hypertension in the group of Kazakh individuals // Nauka i Zdravookhranenie [Science & Healthcare]. 2023, (Vol.25) 5, pp. 45-51. doi 10.34689/SH.2023.25.5.005Похожие публикации:
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