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IMMUNOHISTOCHEMISTRY IN DIAGNOSTICS OF COLORECTAL CANCER AND THE ROLE OF PROLIFERATION MARKER Ki-67
Introduction: the paper presents literature review devoted to the significance of biomarkers in colorectal cancer. Based on the analysis of data presented in evidence-based medicine databases, there is a lot of scientific information enabling appropriate solution of treatment modality.
Aim: to carry the systematic search of research papers dedicated to immunohistochemistry in colorectal cancer and to the significance of proliferation marker Ki67.
Materials and methods. To achieve the above described goal, we conducted a systematic literature search in evidence-based medicine electr...
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2016 год | Выпуск: 5 | Страницы: 150-163

CLINICAL AND MORPHOLOGICAL FEATURES OF BREAST CANCER AMONG WOMEN WITH RADIOECOLOGICAL AND FAMILY ANAMNESIS
The peculiarities of histomorphological characteristics of malignant neoplasm can be linked to its genesis, including the presence of genetic changes in regulatory genes. By-turn, the frequency of the last depends from the influence of mutagenic factors.
The aim. The purpose of research is to determine the morphological features of breast cancer due to the presence of gene mutations BRCА1 and TP53 among women with family and radioecological anamnesis.
Materials and methods. The study included 190 women aged between 40 to 78 years, patients with breast cancer, ethnic Kazakhs, alloc...
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2016 год | Выпуск: 1 | Страницы: 66-76