COMPARATIVE ESTIMATION OF MORBIDITY RATE AND DEGREE OF SKIN LESIONS DURING HYPOFRACTIONATED AND TRADITIONAL RADIOTHERAPY OF BREAST CANCER
Background: Radiation therapy is a necessary step for the integrated treatment of breast cancer. The traditional scheme of treatment is the use of 2 Gray in 25 fractions to the total focal dose of 50 Gy. However, like any other treatment method, radiation therapy provides a variety of side effects on normal tissue in the irradiated field. To solve this problem it is necessary to develop suitable treatment regimens to achieve better local control with minimal risk on the normal tissues.
A variety of hypofractionated radiotherapy schedules has been proposed after surgery in the attempt to shorten the overall treatment time. The aim of the present study is to assess acute toxicity of using daily fractionation of 2.7 Gy to a total dose of 43.2 Gy to the whole breast in a monoinstitutional series.
Methods: Study design is non-randomised clinical trial. 132 Patients were evaluated for toxicity according to RTOG acute adverse effect criteria at the end of treatment and 3, 6 months after treatment. Mann-Whitney U test was used for comparing acute toxicity rate between patients treated with hypofractionation and traditional radiotherapy. A p value of ˂0.05 was taken as significant. The whole analysis was performed with SPSS ver.20 software.
Results: Hypofractionation is very well tolerated; more than 80% of patients had no toxicities at all with the treated schedule. The rate of mild toxicity (> grade 2) was minimum in these patients (p=0.023).
Conclusions: The results of our study, according to the large randomized trials, confirmed that hypofractionated is safe.
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Байсалбаева А.С., Адылханов Т.А., Косымбаева Е.О., Андреева О.Б., Абильтаева А.А. Сравнительная оценка частоты и степеней поражения кожи при гипофракционированной и традиционной лучевой терапии рака молочной железы / / Наука и Здравоохранение. 2016. №6. С. 40-49. Baissalbayeva A.S., Adylkhanov T.A., Kossymbayeva Y.O., Andreeva O.B., Abiltaeva A.A. Comparative estimation of morbidity rate and degree of skin lesions during hypofractionated and traditional radiotherapy of breast cancer. Nauka i Zdravookhranenie [Science & Healthcare]. 2016, 6, pp. 40-49. Байсалбаева А.С., Адылханов Т.А., Косымбаева Е.О., Андреева О.Б., Абильтаева А.А. Сүт безі обырының гипофракционды және дәстүрлі сәулелі терапиясында тері зақымдануының жиілігі мен дәрежесін салыстырмалы бағалау / / Ғылым және Денсаулық сақтау. 2016. №6. Б. 40-49.Похожие публикации:
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