CAUSAL RISK FACTORS FOR MACROSOMIA OF NEWBORNS WITH VITAMIN D DEFICIENCY
Relevance: In the modern world, the frequency of macrosomia is growing dynamically. The World Health Organization (WHO) has recognized obesity, type 2 diabetes mellitus and non-communicable diseases as global epidemics [2]. Macrosomia is defined as a birth weight of more than 4000 g regardless of gestational age and occurs in 3-15% of all pregnancies worldwide [4,9,22]. Vitamin D deficiency during pregnancy is associated with an increased risk of gestational diabetes and preeclampsia, which may indirectly affect the health of offspring [5,6,21].
Objective: To assess risk factors and the level of vitamin D in umbilical cord blood in macrosomal newborns.
Materials and methods of research. Case - control. The study was conducted in the period from January 2021 to April 2021 at the clinical bases "Perinatal Center of Semey and Ust-Kamenogorsk. The study included full-term newborns in the number of 100 children. Informational consents were received from mothers of newborns to participate in the study. The mothers were informed about the processing of the received data, with the subsequent publication of the research results, without specifying personal data. Inclusion criteria: full-term children with macrosomia. Exclusion criteria: children with defects, genetic diseases, premature newborns.
The data analysis was carried out using the SPSS package version 20.0. To check the statistical significance of the differences between the group of "cases" and "controls", the Pearson and Mann-Whitney χ2 criterion was used, and the odds ratio is calculated taking into account the 95% confidence interval. Continuous data is presented in the form of (Me) and standard deviation (CD).
Results: According to the results of the analysis of risk factors, the cause of macrosomia was maternal diabetes mellitus. The study showed that the pronounced vitamin D deficiency in serum was significantly lower in patients with macrosomia compared to normal-weight children.
Conclusion: the leading risk factor for macrosomia was diabetes mellitus of pregnant women. In newborns with macrosomia, a pronounced deficiency of 25(OH) D.
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Оригинальные исследования
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Ailbayeva N.М., Alimbaeva A.R., Tanatarov S.Z., Ahmetzhanova D.О., Lobanov Yu.F., Taiorazova G.B., Berikuly D., Nurgazinova A.K. Causal risk factors for macrosomia of newborns with vitamin D deficiency // Nauka i Zdravookhranenie [Science & Healthcare]. 2022, (Vol.24) 6, pp. 65-70. doi 10.34689/SH.2022.24.6.009Похожие публикации:
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