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IMMUNOHISTOCHEMICAL ANALYSIS EXPRESSION TP73 IN ONCOCYTIC FOLLICULAR ADENOMA OF THE THYROID
Oncocytic follicular adenomas (FAs) of the thyroid are cells neoplasms of follicular origin that predominantly consist of large polygonal cells with eosinophilic and granular cytoplasm. According to some scientific studies, TP73 might play a сertain role in tumor genesis (oncogenesis). Moreover, due to the absence of p53, oncogenes may attract p73 to induce apoptosis in tumor cells. TP53 is a crucial tumor suppressor in preventing the cancerous transformation of cells. There was also a particular focus on the amplification of 1p36 chromosome in oncocytic FA, which contains a t...
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2017 year | Issue: 1 | Pages: 64-73
ASSESSMENT OF TOXICITY OF NEOADJUVANT CHEMOTHERAPY FOR LOCALLY ADVANCED BREAST CANCER
Introduction. In the structure of malignancies in women breast cancer (BC) takes 1st place. In locally advanced breast cancer (LABC) treatment begins with neoadjuvant chemotherapy (CTX), the standard protocols are CMF, FAC, AC. In the trial, we used cytostatic Arglabin isolated from plants endemic to Central Kazakhstan - wormwood smooth, as monotherapy and as addition to AC-protocol.
The objective of the trial - to assess the toxicity of different protocols of neoadjuvant CTX of LABC.
Methods: 93 patients with LABC (T2N1-2M0, T3N0-2M0) ... More
The objective of the trial - to assess the toxicity of different protocols of neoadjuvant CTX of LABC.
Methods: 93 patients with LABC (T2N1-2M0, T3N0-2M0) ... More
2017 year | Issue: 1 | Pages: 52-63
CLINICAL EVALUATION OF THE EFFICIENCY OF ORTHOPEDIC TREATMENT OF PATIENTS WITH EDENTULOUS JAWS WITH COMPLETE REMOVABLE DENTURES USING C-SILICONE MATERIALS FOR FUNCTIONAL IMPRESSIONS
Introduction. Prosthetics of edentulous jaw is one of the most difficult sections of prosthetic dentistry for many years. The difficulty lies in the production of functionally effective complete dentures that are in direct proportion to their fixation on the jaws, stabilization during chewing and even distribution of pressure on the underlying tissues.
The aim of this research was to conduct a comparative clinical evaluation of the efficiency of the complete removable laminar dentures that were made with use of the new materials for functional impressions.
Methods. At... More
The aim of this research was to conduct a comparative clinical evaluation of the efficiency of the complete removable laminar dentures that were made with use of the new materials for functional impressions.
Methods. At... More
2017 year | Issue: 1 | Pages: 37-51
CORRELATION ANALYSIS OF DATA USING STATISTICA AND SPSS SOFTWARE
In this paper we present the main principles of correlation analysis using parametric and non-parametric methods. Algorithms for calculations of Pearson’s, Spearmen’s and Kendall’s coefficients using Statistica 10 and SPSS 20 software are presented. Special emphasis is given to interpretation of results of statistical analysis. The article complements, but does not substitute specialized literature on biostatistics and clinical epidemiology.
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2017 year | Issue: 1 | Pages: 7-36
ABOUT NEED OF IMPLEMENTATION IN EDUCATIONAL PROGRAMS OF AN INTERNSHIP OF PROFESSIONAL TRAINING. LITERATURE REVIEW
Introduction: the literary review is devoted to a question of introduction in educational programs of intership of professional training on the future workplace. The given question is shined in a context actual for system of higher education of Kazakhstan of a problem, realization of dual training.
Objective: a background of an indispensability of introduction in educational programs of intership of professional training on the basis of results of the literary review.
Materials and methods: in article results of the state-of-the-art review are presented. Search of the literature ha... More
Objective: a background of an indispensability of introduction in educational programs of intership of professional training on the basis of results of the literary review.
Materials and methods: in article results of the state-of-the-art review are presented. Search of the literature ha... More
2016 year | Issue: 6 | Pages: 146-159