UNDERSTANDING OF RECURRENT RESPIRATORY INFECTIONS IN CHILDREN AT THE PRESENT STAGE. REVIEW.
Introduction. Recurrent respiratory infections represent a significant burden on both individuals and healthcare systems worldwide. These infections, characterized by repeated episodes of upper and lower respiratory tract infections, are a common cause of morbidity and mortality in all age groups. The impact of recurrent respiratory infections extends beyond the physical symptoms experienced by affected individuals, often resulting in impaired quality of life, increased healthcare utilization, and economic costs.
Aim. To study the features of recurrent respiratory infections in children, based on research data from the current literature in this field.
Search strategy. The study was conducted using databases such as UpToDate, PubMed, Embase, Cochrane Library, and the Google Scholar search engine. The literature search spanned 9 years, from 2015 to 2024 inclusively. Original articles, randomized controlled trials, systematic reviews, and meta-analyses were included in the study.
Results and conclusions. Understanding the underlying causes and mechanisms behind recurrent respiratory infections is crucial for effective management and prevention strategies. Managing recurrent respiratory infections is a complex task that requires a multifaceted approach. This review article has provided an overview of the various factors contributing to these infections, including host immune response, microbial pathogens, and environmental factors.
Adil A. Zhamankulov1,3, https://orcid.org/0000-0002-9928-0617
Rafail I. Rozenson1, https://orcid.org/0000-0001-6088-2269
Marina A. Morenko1, https://orcid.org/0000-0001-9553-3560
Saule B. Maukaeva2, https://orcid.org/0000-0002-2679-6399
Bayan Gani3, https://orcid.org/0000-0002-0897-6353
Madina M. Syzdykova1, https://orcid.org/0000-0001-6863-303X
Aigerim A. Baubekova1, https://orcid.org/0000-0002-4898-7145
1 NCJSC «Astana Medical University», Astana, Republic of Kazakhstan;
2 NCJSC «Semey Medical University», Semey, Republic of Kazakhstan;
3 Corporate Foundation "University Medical Center", Astana, Republic of Kazakhstan.
1. Abdelkader A., Wahba A.A., El-Tonsy M., Zewail A.A., Eldin M.S. Recurrent respiratory infections and vitamin A levels: a link? It is cross-sectional // Medicine. 2022. № 33 (101). P.e30108
2. Avezova G.S., Kosimova S.M. Frequently Ill Children: Prevalence and Risk Factors // European research. 2017. № 5. P. 79-80.
3. Alexandrino A.S., Rita Santosa, Meloa C., Bastos J. Risk factors for respiratory infections among children attending day care centres // Family practice. 2016. № 2 (33). P.161-166.
4. Altamimi A.A., Monique R., Eman M.A., Veselinovi T., Robyn S.M.C., Brennan-Jones C. Recurrent otitis media and behaviour problems in middle childhood: A longitudinal cohort study // Journal of Paediatrics and Child Health. 2023. №1 (60). Р.12-17.
5. Barakat A.N., Mahitab M.H., Eman M.F., Amr M.Z., Ahmed M.A. The Underlying Causes of Recurrent Pneumonia in Children: A Two-Center Study // Journal of Advances in Medicine and Medical Research. 2021. (33). P. 62-69.
6. Bosch A.A.T.M., Piters W.A.D.S., van Houten M.A., Chu M.L.J., Biesbroek G., Kool J., Bogaert D. et al. Maturation of the infant respiratory microbiota, environmental drivers, and health consequences. A prospective cohort study // American Journal of Respiratory and Critical Care Medicine. 2017. №12 (196). P. 1582-1590.
7. Buendía J. A., Patiño D. G. Cost-utility of vitamin D supplementation to prevent acute respiratory infections in children // Cost Effectiveness and Resource Allocation. 2023. № 1(21). P. 23.
8. Cárdenas N., Martín V., Arroyo R., López M., Carrera M., Badiola C., Rodríguez J.M. Prevention of recurrent acute otitis media in children through the use of Lactobacillus salivarius PS7, a target-specific probiotic strain // Nutrients. 2019. №2 (11). P. 376-1-376-14.
9. Chan C.K.Y., Tao J., Chan O.S., Li H.B., Pang H. et al. Preventing respiratory tract infections by synbiotic interventions: a systematic review and meta-analysis of randomized controlled trials //Advances in Nutrition. 2020. № 4(11). P. 979-988.
10. Chiappini E., Santamaria, F., Marseglia, G.L., Paola Marchisio4, Luisa G., Renato C. et al. Prevention of recurrent respiratory infections: inter-society consensus // Italian journal of pediatrics. 2021. (47). P. 1-17.
11. Colunga Biancatelli R.M.L., Berrill M., Marik P. E. The antiviral properties of vitamin C // Expert review of anti-infective therapy. 2020. № 2 (18). P. 99-101.
12. Dang A.T., Pasquali C., Ludigs K., Guarda G. OM-85 is an immunomodulator of interferon-β production and inflammasome activity // Scientific Reports. 2017. (7). P. 43844-1-43844-10.
13. de Araujo G.V., de Oliveira Junior M.H., Peixoto D.M., Emanuel S., Sarinho E.S. Probiotics for the treatment of upper and lower respiratory-tract infections in children: systematic review based on randomized clinical trials // Journal of Pediatrics (Rio). 2015. (91). P.413–27.
14. De Benedictis F.M., Bush A. et al. Recurrent lower respiratory tract infections in children // BMJ. 2018. №7 (362). P. 1-8
15. Dong Y., Mo X., Hu Y., Qi X., Jiang F., Jiang Z. et al. Epidemiology of COVID-19 Among Children in China // Pediatrics. 2020. 6 (145). P.e20200702.
16. Doumat G., Mehta, G. D., Mansbach J.M., Hasegawa K., Camargo J.C.A. Association between Early Childhood Vitamin D Status and Age 6-Year Lung Function among Children with a History of Severe Bronchiolitis in Infancy // Nutrients. 2023. № 10(15). P. 2379.
17. Emre I.E., Eroğlu Y., Kara A., Dinleyici E.C., Özen M. The effect of probiotics on prevention of upper respiratory tract infections in the paediatric community–a systematic review // Beneficial microbes. 2020. № 3(11). P. 201-211.
18. Esposito S., Jones M.H., Feleszko W., Martell J.A.O., Falup-Pecurariu O., Geppe N., Principi N. et al. Prevention of New Respiratory Episodes in Children with Recurrent Respiratory Infections: An Expert Consensus Statement // Microorganisms. 2020. 8, №11 (8). P. 1810-1-1810-19.
19. Esposito S., Lelii M. Vitamin D and respiratory tract infections in childhood // BMC Infection Disease. 2015.(15). P. 487-1-487-16.
20. Ezbakhe F., Pérez-Foguet A. Child mortality levels and trends: A new compositional approach // Demographic Research. 2020. №43 (43). P. 1263-1296.
21. Frieri M., Kumar K., Boutin A. Antibiotic resistance // Journal of infection and public health. 2017. № 4 (10). P. 369-378.
22. Gombart A.F., Pierre A., Maggini S. A review of micronutrients and the immune system - working in harmony to reduce the risk of infection // Nutrients. 2020. №1 (12). P. 236-1-236-27.
23. Götzinger F., Santiago-García B., Noguera-Julián A., Lanaspa M., Lancella L., Calò Carducci F.I. et al. COVID-19 in children and adolescents in Europe: a multinational, multicentre cohort study // The Lancet. Child & adolescent health. 2020. №9(4). P. 653-661.
24. Greiller C.L., Martineau A.R. Modulation of the immune response to respiratory viruses by vitamin D // Nutrients. 2015. №6 (7). P. 4240-4270.
25. Gupta P., Dewan P., Shah D., Sharma N., Bedi N., Kaur I.R. et al. Vitamin D Supplementation for Treatment and Prevention of Pneumonia in Under-five Children: A Randomized Double-blind Placebo Controlled Trial. Indian Pediatrics. 2016. 53(11). P. 967-976.
26. Hagl B., Heinz V., Schlesinger A., Spielberger B.D., Sawalle‐Belohradsky J., Senn‐Rauh M., Renner E.D. et al. Key findings to expedite the diagnosis of hyper-IgE syndromes in infants and young children // Pediatric Allergy and Immunology. 2016. №2 (27). P. 177-184.
27. Hong M., Xiong T., Huang J., Wu Y., Lin L., Zhang Z. et al. Vitamin D supplementation and lower respiratory tract infection in infants: a nested case–control study // Infection. 2023. № 1(51). P. 109-118.
28. Jamal A., Alsabela A., Tarakhmet M., Safar A. Diagnosis, Complications, and Management of Acute Otitis Media in Children // Cureus. 2022. №8 (14). P. 1-7.
29. Khan Laghari I., Nawaz T., Mustafa S., Jamali A.A., Fatima S. Role of multi-strain probiotics in preventing severity and frequency of recurrent respiratory tract infections in children // BMC pediatrics. 2023. №1(23). P. 505.
30. Koatz A.M., Coe N.A., Cicerán A., Alter A.J. Clinical and immunological benefits of OM-85 bacterial lysate in patients with allergic rhinitis, asthma, and COPD and recurrent respiratory infections // Lung. 2016. Vol. 194, №4 (194). P. 687-697.
31. Li L., Wang F., Liu Y., Gu F. Intestinal microbiota dysbiosis in children with recurrent respiratory tract infections // Microbial Pathogenesis Elsevier Ltd. 2019. №1677 (136). P. 103709.
32. Li K.L., Wang B.Z., Li Z.P., Li Y.L., Liang J.J. Alterations of intestinal flora and the effects of probiotics in children with recurrent respiratory tract infection // World Journal of Pediatrics. 2019. №3 (15). P. 255-261.
33. Li K.L., Sinha N., Ojha N.K. Management of Recurrent respiratory disorders: A Case Study // International Journal of Health and Medicine. 2020. № 3 (5). P.1-4.
34. Li X., Wang Q., Hu X., Liu W. Current status of probiotics as supplements in the prevention and treatment of infectious diseases // Frontiers in Cellular and Infection Microbiology. 2022. (12). P. 167.
35. Liu L., Oza S., Hogan D., Perin J., Rudan I., Lawn J. et al. Global, regional, and national causes of child mortality in 2000–13, with projections to inform post-2015 priorities: an updated systematic analysis // Lancet. 2015. №9966 (385). Р. 430-440.
36. Liu Z., Huang S., Yuan X., Wang Y., Liu Y., Zhou J. et al. The role of vitamin D deficiency in the development of paediatric diseases // Annals of Medicine. 2023. № 1(55). P. 127-135.
37. MacLean R.C., San Millan A. The evolution of antibiotic resistance // Science. 2019. № 6458 (365). P. 1082-1083.
38. Marik P.E. Hydrocortisone, ascorbic acid and thiamine (HAT therapy) for the treatment of sepsis. Focus on ascorbic acid // Nutrients. 2018. № 11(10). P. 1762.
39. Marik P.E. Vitamin C for the treatment of sepsis: the scientific rationale // Pharmacology & therapeutics. 2018. (189). P. 63-70.
40. Martineau A.R., Jolliffe D.A., Greenberg L., Aloia J.F., Bergman P., Dubnov-Raz G., Hooper R.L. et al. Vitamin D supplementation to prevent acute respiratory infections: individual participant data meta-analysis // Health Technol Assess. 2019. №2 (23). P. 1-44.
41. Medernach R.L., Logan L.K. The Growing Threat of Antibiotic Resistance in Children // Infectious Disease Clinics of North America. 2018. №1 (32). P. 1-17.
42. Mameli C., Pasinato A., Piccac M., Bedogni G., Pisanelli S., Zuccotti G.V. Pidotimod for the prevention of acute respiratory infections in healthy children entering into daycare: A double blind randomized placebo-controlled study // Pharmacological Research. 2015. (97). P. 79-83.
43. Montella S., Corcione A., Santamaria F. Recurrent pneumonia in children: A reasoned diagnostic approach and a single centre experience // International journal of molecular sciences. 2017. №2 (18). P. 1-13.
44. Munteanu A., Surcel M., Huică R.I., Isvoranu G., Constantin C., Pîrvu I.R. et al. Peripheral immune cell markers in children with recurrent respiratory infections in the absence of primary immunodeficiency // Experimental and Therapeutic Medicine. 2019. №3 (18). Р.1693-1700.
45. Niu H., Wang R., Jia Y.T., Cai Y. Pidotimod, an immunostimulant in pediatric recurrent respiratory tract infections: A meta-analysis of randomized controlled trials // International Immunopharmacology. 2019. (67). P. 35-45.
46. Pasternak G., Lewandowicz-Uszyńska A., Pentoś K. Disorders of humoral immunity in children with IgG subclass deficiency and recurrent respiratory infections // Advances in Experimental Medicine and Biology. 2018. (1108). P. 99-106.
47. Pecora F., Persico F., Argentiero A., Neglia C., Esposito, S. The role of micronutrients in support of the immune response against viral infections // Nutrients. 2020. №10 (12). P.3198-1-3198-35.
48. Puggioni F., Alves-Correia M., Mohamed M.F., Stomeo N., Mager R., Marinoni M., Heffler E. et al. Immunostimulants in respiratory diseases: focus on Pidotimod // Multidisciplinary Respiratory Medicine. 2019. (14). P.31-1-31-15.
49. Raniszewska A., Górska E., Kotuła I., Stelmaszczyk-Emmel A., Popko K., Ciepiela, O. Recurrent respiratory tract infections in children analysis of immunological examinations // Central Europian Journal of Immunology. 2015. №2 (40). P. 167-173
50. Rao K.R., Gandhi S. S., Kokiwar P. R. Clinical study of recurrent respiratory tract illness among pediatric patients // International Journal of Contemporary Pediatrics. 2016. №1 (3). P. 210.
51. Robinson P.F.M., Pattaroni C., Cook J., Gregory L., Alonso A.M., Fleming L.J. et al. Lower airway microbiota associates with inflammatory phenotype in severe preschool wheeze // Journal of Allergy and Clinical Immunology. 2019. №4 (143). P. 1607-1610.e3.
52. Rotiroti G., Roberts G., Scadding G.K. Rhinitis in children: common clinical presentations and differential diagnoses // Pediatric Allergy and Immunology. 2015. №2 (26). Р. 103-110.
53. Sangüesa J., Sunyer J., Garcia-Esteban R., Abellan A., Esplugues A., Garcia-Aymerich J., Casas M. et al. Prenatal and child vitamin D levels and allergy and asthma in childhood // Pediatric research. 2023. № 6 (93). P. 1745-1751.
54. Schloss J., Lauche R., Harnett J., Hannan N., Brown D., Greenfield T. et al. Efficacy and safety of vitamin C in the management of acute respiratory infection and disease: A rapid review // Advances in Integrative Medicine. 2020. № 4 (7). Р. 187-191.
55. Scott A.M., Clark J., Julien B., Islam F., Roos K., Grimwood K., et al. Probiotics for preventing acute otitis media in children // Cochrane Database Systematic Review. 2019. №6. Р. CD012941-1-Cd012941-34.
56. Sun M., Yan Z., Sun R., Tian W., Yi W., Zhang J. Dynamic monitoring and a clinical correlation analysis of the serum vitamin A, D, and E levels in children with recurrent respiratory tract infections // American Journal of Translational Research. 2022. № 5(14). P. 3533.
57. Teo S.M., Mok D., Pham K., Kusel M., Serralha M., Troy N., Inouye M. The infant nasopharyngeal microbiome impacts severity of lower respiratory infection and risk of asthma development // Cell Host Microbe. Elsevier Inc. 2015. №5 (17). P. 704-715.
58. Toivonen L., Karppinen S., Schuez-Havupalo L., Teros-Jaakkola T., Vuononvirta J., Mertsola J. et al. Burden of recurrent respiratory tract infections in children // The Pediatric infectious disease journal. 2016. № 12 (35). Р. e362-e369.
59. Tian W., Yi W., Zhang J., Sun M., Sun R., Yan Z. The correlation between the vitamin A, D, and E levels and recurrent respiratory tract infections in children of different ages // American Journal of Translational Research. 2021. № 5(13). P. 5665.
60. Trandafir L.M., Boiculese L.V., Dimitriu G. Moscalu M. Recurrent respiratory tract infections in children. 2017 E-Health and Bioengineering Conference (EHB). – IEEE. 2017. P. 741-744.
61. Vakili R., Gholamreza K., Vakili S., Saeidi M. Child mortality at different world regions: A comparison review // International journal of Pediatrics. 2015. №4.2 (3). Р. 809-816.
62. Vuichard Gysin D., Dao D., Gysin C.M., Lytvyn L., Loeb M. Effect of vitamin D3 supplementation on respiratory tract infections in healthy individuals: a systematic review and meta-analysis of randomized controlled trials // PloS One. 2016. №9 (11). P. e0162996-1-e0162996-11.
63. Wang Y., Li X., Ge T., Xiao Y., Liao Y., Cui Y. et al. Probiotics for prevention and treatment of respiratory tract infections in children: A systematic review and meta-analysis of randomized controlled trials // Medicine. 2016. №31 (95). P. e4509-1-e4509-11.
64. Wang X. Li X., Jin C., Bai X., Qi X., Wang J. et al. Association between serum vitamin A levels and recurrent respiratory tract infections in children // Frontiers in Pediatrics. 2021. (9). P. 756217.
65. Woicka-Kolejwa K., Zaczeniuk M., Majak P., Pawłowska-Iwanicka K., Kopka M., Stelmach W. et al. Food allergy is associated with recurrent respiratory tract infections during childhood // Postep Dermatologii i Alergol. 2016. №2 (33). P. 109-113.
66. Wypych T.P., Wickramasinghe L.C., Marsland B.J. The influence of the microbiome on respiratory health // Nature immunology. 2019. № 10(20). P. 1279-1290.
67. Zhamankulov A.A., Morenko M.A., Rozenson R.I. Recurrent respiratory infections: criteria, etiology, risk factors, diagnosis // Valeology. 2019. № 4. P.16-20.
68. Zhang X., Ding F., Li H., Zhao W., Jing H., Yan Y. et al. Low serum levels of vitamins A, D, and E are associated with recurrent respiratory tract infections in children living in Northern China: a case control study // PLoS One. 2016. № 12(11). P. e0167689.
69. Zhao N., Liu C., Zhu C., Dong X., Liu X. Pidotimod: a review of its pharmacological features and clinical effectiveness in respiratory tract infections // Expert Review of Anti-infective Therapy. 2019.Vol. 17, №10 (17). P.803-818.
70. Zhao Y., Dong B.R., Hao Q. Probiotics for preventing acute upper respiratory tract infections // Cochrane database of systematic reviews. 2022. № 8. P.1-119.
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Zhamankulov A.A., Rozenson R.I., Morenko M.A., Maukaeva S.B., Gani B., Syzdykova M.M., Baubekova A.A. Understanding of recurrent respiratory infections in children at the present stage. Review // Nauka i Zdravookhranenie [Science & Healthcare]. 2024, Vol.26 (2), pp. 184-191. doi 10.34689/SH.2024.26.2.021Related publications:
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