Online ISSN: 3007-0244,
Print ISSN:  2410-4280


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ДЕФИЦИТ АЛЬФА-1 - АНТИТРИПСИНА И ХРОНИЧЕСКАЯ ОБСТРУКТИВНАЯ БОЛЕЗНЬ ЛЕГКИХ
Introduction. Alpha-1-antitrypsin deficiency (AATD) is a genetic disorder that manifests as pulmonary emphysema, liver cirrhosis and, rarely, as the skin disease panniculitis, and is characterized by low serum levels of AAT, the main protease inhibitor (PI) in human serum. The prevalence in Western Europe and in the USA is estimated at approximately 1 in 2,500 and 1 : 5,000 newborns, and is highly dependent on the Scandinavian descent within the population.
Chronic obstructive pulmonary disease (COPD) is one of the most essential causes of morbidity and mortality...
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2016 год | Выпуск: 1 | Страницы: 127-136