ОЦЕНКА ВЛИЯНИЯ ПОЛИМОРФИЗМА ГЕНА IL-10 НА ИСХОДЫ ХРОНИЧЕСКИХ ВИРУСНЫХ ГЕПАТИТОВ В КАЗАХСКОЙ ПОПУЛЯЦИИ: ИССЛЕДОВАНИЕ СЛУЧАЙ-КОНТРОЛЬ
2015 year | Issue: 6 | Pages: 67-76
ЭТИЧЕСКОЕ РЕГУЛИРОВАНИЕ НАУЧНЫХ ИССЛЕДОВАНИЙ С УЧАСТИЕМ ЧЕЛОВЕКА
В статье представлены основные правила проведения биомедицинских исследований, задачи локальных комиссий по вопросам этики, принципы биоэтического регулирования проведения научных исследований по изучению состояния здоровья населения, подвергшегося радиационному воздействию в результате испытаний ядерного оружия на Семипалатинском полигоне. Описаны элементы информированного согласия по проведению скрининговых и углуб-ленных клинических исследований.
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2014 year | Issue: 3 | Pages: 57-58
ВЫДЕЛЕНИЕ И ОЧИСТКА НУКЛЕИНОВЫХ КИСЛОТ. СОСТОЯНИЕ ПРОБЛЕМЫ НА СОВРЕМЕННОМ ЭТАПЕ
В статье представлены стандартные и инновационные методы выделения ДНК, указаны преимущества и недо-статки различных способов экстракции ДНК. Описана качественная и количественная оценка нуклеиновых кислот для получения наиболее полноценной ДНК, позволяющая потом ее использовать в широком диапазоне научных исследований.
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2014 year | Issue: 1 | Pages: 51-53
МОЛЕКУЛЯРНО-ГЕНЕТИЧЕСКИЕ МЕХАНИЗМЫ РАЗВИТИЯ ОСЛОЖНЕНИЙ ХРОНИЧЕСКИХ ВИРУСНЫХ ГЕПАТИТОВ В И С (Обзор литературы)
Вирусные гепатиты являются одной из значимых проблем гепатологии в мире. Хронические вирусные гепатиты, как известно, проявляют высокую склонность к трансформации в цирроз печени и гепатоцеллюлярную карциному. В настоящей обзорной статье рассматриваются вопросы прогнозирования трансформации вирусного гепатита В и С в цирроз печени и гепатоцеллюлярную карциному.
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2014 year | Issue: 1 | Pages: 11-14
АНАЛИЗ РАСПРОСТРАНЕННОСТИ БОЛЕЗНЕЙ СИСТЕМЫ КРОВООБРАЩЕНИЯ СРЕДИ ГРУПП РАДИАЦИОННОГО РИСКА, ПРОШЕДШИХ СКРИНИНГОВОЕ ОБСЛЕДОВАНИЕ
2013 year | Issue: 6 | Pages: 44-46
СЕМЕЙ ЯДРОЛЫҚ ПОЛИГОНЫНЫҢ ІРГЕЛЕС АУМАҚТАРЫНДАҒЫ ТҰРҒЫНДАРЫНЫҢ АУРУЫНЫҢ ТАРАЛУЫН ТАЛДАУ
2013 year | Issue: 6 | Pages: 42-43
ӨТ – ТАС АУРУЫМЕН ҚОСАРЛАСҚАН ҚАНАЙНАЛЫМ ЖҮЙЕСІ АУРУЛАРЫНЫҢ ҚАУІП ФАКТОРЛАРЫН ЗЕРТТЕУ
2012 year | Issue: 6 | Pages: 47-48
СЕМЕЙ АЙМАҒЫНДАҒЫ ТҰРҒЫНДАРДЫҢ ЖИА КЕЗІНДЕГІ ЛИПИДТЫ АУМАСУДЫ ЗЕРТТЕУДІ ӨТКІЗУ
2012 year | Issue: 6 | Pages: 29-30
ХЛАМИДИЯ ЖҰҚПАЛЫ АУРУЫНЫҢ ЗЕРТХАНАЛЫҚ ДИАГНОСТИКАСЫ
Урогенитальды хламидиозды диагностикасында микроскопиялық әдіс 2% косу жолымен ДМСО, сезімталды әдісті 30% жоғарлату мүмкіндігін авторлармен жетілдірді.
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2012 year | Issue: 1 | Pages: 57-58
АЛМАТЫ ЖӘНЕ СЕМЕЙ Қ.Қ.ЖИІ КЕЗДЕСЕТІН АУРУХАНАДАН ТЫС БАЛАЛАРДАҒЫ ПНЕВМОНИЯНЫ ШАҚЫРАТЫН, МИКРОАҒЗАЛАРДЫҢ СЕЗІМТАЛДЫҒЫ
2012 year | Issue: 1 | Pages: 16-17
PREVALENCE AND SEVERITY OF SOMATIC DISTRESS AND FATIGUE AMONG RESIDENTS OF EAST KAZAKHSTAN REGION EXPOSED TO RADIATION DUE TO THE ACTIVITY OF THE SEMIPALATINSK NUCLEAR TEST SITE
Background: since Kazakhstan belongs to the range of industrialized world nations, most of its territory is affected by anthropogenic and man-induced risk factors, which contribute to the development of unfavorable ecological situation that has negative impact on the population health. Nuclear weapons tests at the Semipalatinsk nuclear test site have caused significant adverse changes in the habitat of hundreds of thousands of people who are now forced to live and conduct economic activities in territories contaminated with radionuclides. Studying the long-term effects of small radiation doses...
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2018 year | Issue: 5 | Pages: 125-134
POLYMORPHISMS OF GENES IN HYPERTENSION: RENIN - ANGIOTENSIN - ALDOSTERONE SYSTEM. REVIEW
The study of polymorphisms of genes responsible for the development of arterial hypertension is a promising direction of medicine. Hypertension is a multifactorial disease that depends on lifestyle, environment and nutrition, as well as polymorphisms of genes. Polymorphisms of the genes of the renin - angiotensin - aldosterone system play an important role in the pathogenesis of hypertension.
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2018 year | Issue: 1 | Pages: 116-130
RISK OF DISORDERS OF NONSPECIFIC RESISTANCE DUE TO LONG-TERM EXPOSURE TO RADIATION IN SMALL DOSES
Background: long-term exposure to ionizing radiation in small doses on the human body is manifested by violations of the adaptive response of regulatory systems to stress.
Aim: to perform a systematic search of valid scientific data in order to assess the disorders of nonspecific resistance in the human organism due to long-term exposure to radiation in small doses
Materials and methods. The search for scientific publications was carried out in the evidence-based medicine’s databases (PubMed, Cochrane Library, ResearchGate, Google Scholar) and in the electron... More
Aim: to perform a systematic search of valid scientific data in order to assess the disorders of nonspecific resistance in the human organism due to long-term exposure to radiation in small doses
Materials and methods. The search for scientific publications was carried out in the evidence-based medicine’s databases (PubMed, Cochrane Library, ResearchGate, Google Scholar) and in the electron... More
2017 year | Issue: 5 | Pages: 158-171
POLYMORPHISM OF IL10 GENE AT -1082G/A POSITION IN PATIENTS WITH ERYSIPELAS
The aim of this study is reveal the association of polymorphism of IL10 gene (rs1800896) at 1082 GA position with the erysipelas in Kazakh population.
Materials and methods. The polymorphism of IL10 gene (rs1800896) was assessed in 206 patients with erysipelas and 422 control subjects. Of them 143 patients with primary erysipelas and 63 with recurrence erysipelas. Genomic DNA was extracted from blood for genotyping. Genotyping of polymorphism of IL10 gene (-1082 GA) was conducted by method of polymerase chain reaction in real time. Pearson’s Chi tests ... More
Materials and methods. The polymorphism of IL10 gene (rs1800896) was assessed in 206 patients with erysipelas and 422 control subjects. Of them 143 patients with primary erysipelas and 63 with recurrence erysipelas. Genomic DNA was extracted from blood for genotyping. Genotyping of polymorphism of IL10 gene (-1082 GA) was conducted by method of polymerase chain reaction in real time. Pearson’s Chi tests ... More
2016 year | Issue: 3 | Pages: 34-45
COMPARATIVE EVALUATION OF TYPING METHODS FOR E.COLI - MLST AND SEROTYPING
2015 year | Issue: 6 | Pages: 77-82