Online ISSN: 3007-0244,
Print ISSN:  2410-4280
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ФАКТОРЫ, ВЛИЯЮЩИЕ НА ОДНОЛЕТНЮЮ ВЫЖИВАЕМОСТЬ ПАЦИЕНТОВ ПОСЛЕ ИНСУЛЬТА В КАЗАХСТАНЕ: КОГОРТНОЕ ИССЛЕДОВАНИЕ
Введение. Существует много нерешенных вопросов относительно предикторов исхода мозгового инсульта (МИ). В литературе имеется единичные публикации по детерминантам исхода МИ в Казахстане, несмотря на высокую распространенность проблемы.
Целью настоящего исследования являлось оценка влияния факторов риска на выживаемость больных с инсультом в течение года в популяции г. Семей.
Методы. В когортное исследование были включены все случаи МИ в г. Семей с 01.01.2014г. до 31.12.15г. (n=937). Выживаемость больных с МИ оценивалась с помощью метода Kaплана-Mайера с определение...
Толығырақ
2016 жыл | Шығарылым: 3 | Беттер: 46-57

ПОЛИМОРФИЗМ ГЕНА ИЛ10 В ПОЛОЖЕНИИ -1082G/A У БОЛЬНЫХ РОЖЕЙ
Целью данного исследования является выявление связи полиморфизма гена ИЛ10-1082 GA (rs1800896) с заболеванием рожей у лиц казахской национальности.
Материалы и методы: Полиморфизм гена ИЛ10-1082 GA изучен у 206 больных рожей и 422 лиц контрольной группы. Из них у 143 больных первичной рожей и 63 больных рецидиврующей рожей. Для генотипирования были выделены геномная ДНК из крови. Генотипирование проводили методом полимеразной цепной реакции в режиме реал-тайм. Для статистической обработки использовались критерий χ2Пирсона и отношение шансов (ОШ) с 95% доверительными ...
Толығырақ
2016 жыл | Шығарылым: 3 | Беттер: 34-45

ИЗМЕНЕНИЯ В ПЛАЗМЕ ТРИЙОДТИРОНИНА, ТИРОКСИНА И ТИРЕОТРОПНОГО ГОРМОНА ПОСЛЕ ОБЛУЧЕНИЯ 131 I У НОВОРОЖДЕННЫХ КРЫС, СОДЕРЖАВШИХСЯ НА ЙОДОДЕФИЦИТНОМ ПИТАНИИ
Background: Human thyroid gland is generally regarded as a relatively low-risk organ in terms of developing radiation-induced tumorigenesis. However, a rapid increase in the incidents of thyroid cancer after the Chernobyl nuclear reactor accident in 1986 provided additional insight into the risk of thyroid cancer. Three key risk factors have been identified to be involved in this increase: (1) internal irradiation from 131I fallout, (2) young age, and (3) a low-iodine diet. Our previous study demonstrated that the thyroid radiation dose was highest in the newborn rats f...
Толығырақ
2016 жыл | Шығарылым: 3 | Беттер: 26-33

СРАВНЕНИЕ КОЛИЧЕСТВЕННЫХ ДАННЫХ ДВУХ ПАРНЫХ ВЫБОРОК С ИСПОЛЬЗОВАНИЕМ ПРОГРАММНОГО ОБЕСПЕЧЕНИЯ STATISTICA И SPSS: ПАРАМЕТРИЧЕСКИЕ И НЕПАРАМЕТРИЧЕСКИЕ КРИТЕРИИ
В настоящей работе представлены общие сведения об использовании парного критерия Стьюдента, непараметрического критерия Вилкоксона и критерия знаков для сравнения количественных признаков парных выборок. Описан алгоритм расчета данных критериев с использованием программного обеспечения Statistica 10 и SPSS 20 и представлена интерпретация результатов расчетов. Настоящая статья призвана дать общие сведения об использовании парного критерия Стьюдента, парного критерия Вилкоксона и критерия знаков, и не заменяет прочтения специализированной литературы по статистике и клинической эпидемиологии.
Толығырақ
2016 жыл | Шығарылым: 3 | Беттер: 5-25

RISK FACTORS FOR CERVICAL CANCER IN SEMEY REGION
Background: The aim of investigation was to study the main risk factors for cervical cancer in Semey region.
Method: case-control study.
Conclusions. Risk factor for cervical cancer in Semey region for women with uncompleted and secondary school educa-tion is higher than for women with high school education. Also the main risk factors for cervical cancer in study region were the time of starting of menstrual periods, abortion, erosion of cervix, and kind of contraception.
Толығырақ
2014 жыл | Шығарылым: 4 | Беттер: 23-25

ANALYSIS OF TRENDS IN THE INCIDENCE OF HOSPITALIZED ACUTE MYOCARDIAL INFARCTION IN SEMEY REGION
This study attempted to investigate the incidence of hospitalized acute myocardial infarction (AMI) in Semey region. Using the №14 “Report on contingent of patients discharged from hospital” and №30 “Report of medical organization” data, we investigated trends in the incidence of AMI during 2008 to 2012. In conclusion, the incidence and lethality rates of hospitalized AMI had decreased, and the average rates of decline were Т= – 5.43% and Т= – 3.15%, respectively.
Толығырақ
2014 жыл | Шығарылым: 4 | Беттер: 17-23

INDICATORS OF DAILY MONITORING OF THE BLOOD PRESSURE IN CHILDREN WITH ARTERIAL HYPERTENSION BORN FROM IRRADIATED PARENTS
Daily monitoring of blood pressure (DMBP) was conducted on 48 children with arterial hypertension (AH) and without AH. On the basis of DMBP the groups of children with a stable and labile AH options were selected. According to the studies’ results, it is observed that the absolute majority of children (62.9% of boys and 61.4% of girls) without AH has nighttime blood pressure reduction from 10 to 20%, whereas among patients with AH predominant number of patients has minor nighttime blood pressure reduction; moreover, nighttime increase of blood pressure is ob...
Толығырақ
2014 жыл | Шығарылым: 4 | Беттер: 13-16

SEVERE EXACERBATION OF ASTHMA. DIAGNOSIS, TREATMENT
The exacerbation of bronchial asthma (BA) - is a progressive increase in episodes of coughing, shortness of breath, the appearance of wheezing, breathlessness, feeling short of breath, or various combinations of these symptoms [7,11].
Treatment of acute asthma depends on the patient, experience of medical personnel, on the most effective treatment for each individual patient, the availability of drugs and the availability of equipment for emergency care [15,22].
Mainstay of treatment for acute asthma are multiple appointment of fast inhaled b2-agonist or a combination of ...
Толығырақ
2014 жыл | Шығарылым: 4 | Беттер: 9-12

MODELING OF TYPE 2 DIABETES MELLITUS IS A NECESSARY FOUNDATION FOR STUDY OF MEDICINAL PRODUCTS WITH ANTIDIABETIC POTENCY
Taking into account the worldwide increasing number of patients with type 2 diabetes mellitus, the actual problem of modern pharmacology continues to be the development of antidiabetic drugs with high therapeutic activity and having a better risk-benefit profile. In this connection diabetes modeling is very important, it allows reliably detect the presence of a particular pharmacological activity or new components in the mechanism of drugs action. Models of diabetes can be obtained from various species of animals spontaneously, induced by chemical diabetogenic substances, dietary or surgical p...
Толығырақ
2014 жыл | Шығарылым: 4 | Беттер: 4-8