EXPLORING THE ROLE OF miRNA’S IN DRUG-RESISTANT EPILEPSY. A LITERATURE REVIEW
Background: Drug-resistant epilepsy is a complex clinical problem with a multifactorial basis, including both environmental and genetic factors, affecting one in three patients. Understanding the genetic factors underlying this resistance may improve prognosis and support the development of new targeted therapies. This systematic review examines the potential of microRNA (miRNA)-based therapies in overcoming pharmacoresistance, exploring their role in modulating epileptogenic processes and serving as biomarkers for personalized treatment.
Aim: The aim of this study is to explore the important role of miRNA expression in the development of drug-resistant epilepsy by conducting a systematic review using databases such as Scopus, PubMed, Google Scholar, Lilacs, and Cuiden.
Search strategy: A systematic review of the literature was conducted using the Scopus, PubMed, Google Scholar, and SciVerse databases. Data from news articles, press releases, or websites were excluded. The search covered the last 5 years (2019–2024) and was performed in PubMed, Scopus, and Web of Science databases. Relevant articles were cited, focusing on topics closely related to the subject of this study. The literature review specifically investigated the role of miRNA in drug-resistant epilepsy and included open-access review articles in the field of epilepsy. The article was prepared as part of a study funded by the Science Committee of the Ministry of Science and Higher Education of the Republic of Kazakhstan (Grant No. AP23489425).
Results: During the open-access literature search, 112 articles in English were identified. Duplicate publications, animal studies, and publications in languages other than English were excluded from the evaluation. After careful review, 32 articles were selected for full analysis.
Conclusion: Expanding research on the heritability of drug-resistant epilepsy through miRNA studies, particularly in Kazakhstan, will facilitate early diagnosis, improve treatment approaches, and ultimately enhance patient quality of life.
Көрген адамдардың саны: 21
Мақалалар санаты:
Әдебиеттерге шолу
Библиографиялық сілтемелер
Doszhanov I.A., Nurdinov N.S., Abilov T.S., Sadykova K.Zh., Nuskabayeva G.O., Zharkynbekova N.A., Oshibayeva A.E., Aimakhanov M.S. Exploring the Role of miRNA’s in drug-resistant epilepsy: a literature review // Nauka i Zdravookhranenie [Science & Healthcare]. 2025. Vol.27 (1), pp. 167-173. doi 10.34689/SH.2024.27.1.020Ұқсас жариялымдар:
ANALYSIS OF ANTIBIOTIC PRESCRIBING PRACTICES IN PRIMARY HEALTH CARE SETTINGS. PART I
GENETIC SUSCEPTIBILITY TO RADIATION-RELATED DISEASES: A REVIEW OF CURRENT LITERATURE
ТЕНДЕНЦИИ ЗАБОЛЕВАЕМОСТИ ИНФЕКЦИОННОГО ЭНДОКАРДИТА ПОСЛЕ ОБНОВЛЕНИЯ МЕЖДУНАРОДНЫХ РУКОВОДСТВУЮЩИХ ПРИНЦИПОВ. ОБЗОР ЛИТЕРАТУРЫ.
СРАВНЕНИЕ МЕТОДОВ МОДЕЛИРОВАНИЯ РЕЦЕССИИ ДЕСНЫ НА ЛАБОРАТОРНЫХ ЖИВОТНЫХ
THE ROLE OF ESSENTIAL AND TOXIC TRACE ELEMENTS IN THE DEVELOPMENT OF KIDNEY STONE DISEASE. LITERATURE REVIEW