INFLUENCE OF SEX HORMONE-BINDING GLOBULIN (SHBG) ON THE LEVEL OF FREE TESTOSTERONE FRACTION IN OLDER OVERWEIGHT MEN
Relevance. Serum SHBG concentration varies across different stages of a man’s life. In individuals with excess body weight and visceral obesity, SHBG levels may decrease, which in turn disrupts the balance between bound and free testosterone. This may lead to functional hypogonadism, particularly in middle-aged and older men. However, the mechanisms and the extent of SHBG influence on free testosterone levels in the context of excess body weight remain a subject of scientific debate.
Study objective. To assess the effect of sex hormone-binding globulin (SHBG) on the level of free testosterone fraction in men with excess body weight.
Materials and methods. The study involved 326 men living in Semey, Abay region. The subjects were stratified by body mass index (BMI) and divided into two groups: the study group (112 overweight men, BMI 25-29.9 kg/m²) and the control group (214 normal-weight men, BMI <25 kg/m²).
Results. Sex hormone-binding globulin (SHBG) levels were negatively correlated with body mass index, rs = -0.218. Free testosterone showed no differences between the normal-weight and overweight groups. A significant correlation was found between SHBG and free testosterone (rs = -0.422, p < 0.01). This confirms the role of SHBG in regulating free testosterone levels in the blood.
Discussion. With excess weight, SHBG levels in the blood decrease, which then has a cascading effect on the distribution of testosterone between its bound and free fractions. A significant correlation between SHBG and free testosterone has been proven. SHBG plays a key role in the binding and transport of sex hormones.
Conclusions. A significant correlation between SHBG and free testosterone has been demonstrated. In older men, erectile function is determined not only by the level of free testosterone but also by the condition of vascular, endothelial, neural, and metabolic regulation.
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Akkaliyev M.N., Massabayeva M.R., Kazangapov R.S., Rakhyzhanova S.О., Apsalikov B.А., Zhunuspekova А.S., Bazarbekov R.Zh., Bukharieva S.S. Influence of Sex Hormone-Binding Globulin (SHBG) on the Level of Free Testosterone Fraction in Older Overweight Men // Nauka i Zdravookhranenie [Science & Healthcare]. 2025. Vol.27 (6), pp. 14-20. doi 10.34689/SH.2025.27.6.002Ұқсас жариялымдар:
COMPARATIVE EVALUATION OF BLOOD COLLECTION TUBES AND EXTRACTION METHODS FOR CIRCULATING TUMOR DNA
INFLUENCE OF SEX HORMONE-BINDING GLOBULIN (SHBG) ON THE LEVEL OF FREE TESTOSTERONE FRACTION IN OLDER OVERWEIGHT MEN
GENETIC VARIANTS IN LIPID-ASSOCIATED GENES IN THE KAZAKHSTANI COHORT WITH ATHEROSCLEROSIS AND HYPERTRIGLYCERIDEMIA
CLONAL HEMATOPOIESIS WITH INDETERMINATE POTENTIAL IN TET2 AND DNMT3A AMONG KAZAKHSTANI INDIVIDUALS WITH ATHEROSCLEROTIC DISEASE
PRELIMINARY ANALYSIS AND ASSESSMENT OF THE HEALTH STATUS OF THE DESCENDANTS OF PERSONS EXPOSED TO RADIATION, LIVING IN THE BESKARAGAI DISTRICT OF THE ABAY REGION