Online ISSN: 3007-0244,
Print ISSN:  2410-4280
АРТЕРИЯЛЫҚ ГИПЕРТЕНЗИЯ КЕЗІНДЕ ГЕНДЕР ПОЛИМОРФИЗМДЕРІ: РЕНИН – АНГИОТЕНЗИН – АЛЬДОСТЕРОН ЖҮЙЕСІ. ӘДЕБИЕТТІК ШОЛУ

Артериялық гипертензия дамуына жауапты гендер полиморфизмдерін зерттеу медицинаның көп үміт күтерлік бағытына жатады. Артериялық гипертензия өмір сүру салтына, қоршаған ортаға және тамақтануға, сонымен қатар гендер полиморфизміне тәуелді мультифакторлы ауру. Ренин–ангиотензин–альдостерон жүйесінің гендер полиморфизмдері артериялық гипертензия патогенезінде айтарлықтай маңызды рөл атқарады.

Айжан Т. Шаханова 1, http://orcid.org/0000-0001-8214-8575

Нурлан Е. Аукенов 2, http://orcid.org/0000-0002-3163-2997

Алма У. Нуртазина 3, http://orcid.org/0000-0002-9737-4003

 

1 Ішкі аурулар пропедевтика кафедрасы, 2 Біріктірілген оқу-ғылыми зертхана,

3 Жалпы дәрігерлік практика кафедрасы

Семей қаласының мемлекеттік медицина университеті,

Семей қ., Қазақстан Республикасы

1. Акильжанова А. Р., Кожамкулов У.А., Каиров У.Е., Рахимова С.Е., Ахметова А.Ж., Ережепов Д.А., Молкенов А.Б., Абилова Ж.М. Жумадилов Ж.Ш. Исследование генетических вариантов, ассоциированных с гипертонией, ожирением и диабетом у лиц казахской популяции для последующего изучения взаимосвязей генетических вариантов и метаболома // Наука и Здравоохранение. 2016. №4. С. 30-42.

2. Шацкая Е.Г., Карпенко М.А., Ларионова В.И. Полиморфизм “кандидатных” генов и артериальная гипертензия, осложненная инсультом // Вестник Российской военно-медицинской академии. 2011. Т. 1. № 33. С. 35–42.

3. Abdollahi M.R. and others Quantitated transcript haplotypes (QTH) of AGTR1, reduced abundance of mRNA haplotypes containing 1166C (rs5186: A> C), and relevance to metabolic syndrome traits // Hum. Mutat. 2007. V. 28. № 4. P. 365-373.

4. Androulakis E. et al. The impact of an aldosterone synthase (CYP11B2) polymorphism on vascular function and inflammatory biomarkers in essential hypertension acc Moderated Poster Contributions // J. Am. Coll. Cardiol. 2012. Vol. 59. No. 13. S. E1634.

5. Becker K.G. and others. The Genetic Association Database // Nat. Genet. 2004. P. 36. № 5. P. 431-432.

6. Behravan J., Naghibi M., Mazloomi M.A. Polymorphism of angiotensin II type 1receptor gene in Essential Hypertension in Iranian population // DARU. 2006. T. 14. № 2. P. 82-86.

7. Byrd J.B., Auchus R.J., White P.C. Aldosterone Synthase Promoter Polymorphism and Cardiovascular Phenotypes in a Large, Multiethnic Population-Based Study // J. Investig. Med. 2015. P. 63. № 7. P. 862-866.

8. Campbell C.Y. Associations between Genetic Variants in the ACE, AGT, AGTR1 and AGTR2 Genes and Renal Function in the Multi-Ethnic Study of Atherosclerosis // Am. J. Nephrol. 32. 32. № 2. P. 156-162.

9. Chandra S. et al. Atrial natriuretic peptide and aldosterone synthase gene in essential hypertension: A case-control study // Gene. 2015. P. 567. № 1. P. 92-97.

10. Chen J. et al. Lack of association of CYP11B2-344C / T polymorphism with essential hypertension: a meta-analysis // 2015. T. 8. No. 6. P. 9162-9167.

11. Cwynar M. et al. Blood pressure, arterial stiffness and endogenous lithium clearance in relation to AGTR1 A1166C and AGTR2 G1675A gene polymorphisms. / / J. Renin. Angiotensin. Aldosterone. Syst. 2016. T. 17. № 2. S. 1-12.

12. Dai H.J. and others. T-HOD: A literature-based candidate gene database for hypertension, obesity and diabetes // Database. 2013. S. 2013. S. 1-8.

13. Fabris B., Bortoletto M., Candido R., Barbone F., Cattin M.R., Calci M., Scanferla F., Tizzoni L., Giacca M. Genetic polymorphisms of the renin-angiotensin-aldosterone system and renal insufficiency in essential hypertension // J Hypertens. 2005. T. 23 (2). Pp. 309-16.

14. Fatini C. et al., Multilocus analysis in candidate genes ACE, AGT, and AGTR1 and predisposition to peripheral arterial disease: Role of ACE D / -240T haplotype // J. Vasc. Surg. 2009. T. 50. № 6. P. 1399-1404.

15. Fung M.M. et al., Early inflammatory and metabolic changes in association with AGTR1 polymorphisms in prehypertensive subjects, Am. J. Hypertens. 2011. P. 24. 24. № 2. P. 225-233.

16. Gnickenig G., Harrison D.G. The AT1-Type Angiotensin Receptor in Oxidative Stress and Atherogenesis Part II: AT1 Receptor Regulation // Circulation. 2002. Vol. 105. S. 530-536.

17. Gatti R.R. and others. The interaction of AGT and NOS3 gene polymorphisms with conventional risk factors increases the predisposition to hypertension // JRAAS-J. Renin-Angiotensin-Aldosterone Syst. 2013. P. 14. № 4. P. 360-368.

18. Gu D. et al. Association Study 33 Single-Nucleotide Polymorphisms in 11 Candidate Genes for Hypertension in Chinese // Hypertension. 2006. No. 1147-1154.

19. Henderson O., Christopher A. W.M. Multiple Polymorphisms in the Renin-Angiotensin-Aldosterone System (ACE, CYP11B2, AGTR1) and Their Contribution to Hypertension in African Americans and Latinos in the Am. J. Med. Sci. 328. № 5. P. 266-273.

20. Herrera C.L. Association of polymorphisms within the Renin-Angiotensin System with metabolic syndrome in a cohort of Chilean subjects // Arch Endocrinol Metab. 2016. Vol. 60. No. 3. P. 190-8.

21. Hsiao C.-F. et al., The effects of the renin-angiotensin-aldosterone system gene polymorphisms on insulin resistance in hypertensive families. J. Renin-Angiotensin-Aldosterone Syst. 2012. T. 13. № 4. P. 446-454.

22. Imaizumi T. et al., Association of Interactions between dietary salt consumption and hypertension-susceptibility genetic polymorphisms with blood pressure among Japanese male workers, Clin. Exp. Nephrol. 2017. Vol. 21. No. 3. S. 457-464.

23. Ji L. et al., The Association between Polymorphisms in the Renin-Angiotensin-Aldosterone System Genes and Essential Hypertension in the Han Chinese Population // PLoS One. 2013. 8. 8. № 8. P. 4-9.

24. Ji L.D. and others. Are genetic polymorphisms in the renin-angiotensin-aldosterone system associated with essential hypertension? Evidence from genome-wide association studies // J. Hum. Hypertens. 2017. V. 31. 11. P. 695-698.

25. Jia M. et al. Computational analysis of the functional single nucleotide polymorphisms associated with the CYP11B2 gene // PLoS One. 2014. T. 9. № 8.

26. Kim Y.R. and others. Association of the K173R variant and haplotypes in the aldosterone synthase gene with essential hypertension // Genes and Genomics. 2014. P. 36. № 5. P. 625-632.

27. Kolovou V. et al. Angiotensinogen (AGT) M235T, AGT T174M and Angiotensin-1-Converting Enzyme (ACE) I / D Gene Polymorphisms in Essential Hypertension: Effects on Ramipril Efficacy // Open Cardiovasc. Med. J. 2015. 9. 9. P. 118-126.

28. Lapierre A.V. Angiotensin II type 1 receptor gene polymorphism and essential hypertension in San Luis. // Biocell. 2006. Т. 30. № 3. С. 447–455.

29. Li H. et al. The relationship between angiotensinogen gene polymorphisms and essential hypertension in a Northern Han Chinese population // Angiology. 2014. Т. 65. № 7. С. 614–619.

30. Li X. et al. CYP11B2 gene polymorphism and essential hypertension among Tibetan, Dongxiang and Han populations from northwest of China // Clin. Exp. Hypertens. 2016. Т. 38. № 4. С. 375–380.

31. Li Y.Y. Lack of association of A-6G polymorphism of AGT gene with essential hypertension in the Chinese population // J. Cardiovasc. Med. 2012. Т. 13. № 8. С. 505–510.

32. Lifton R.P. et al. Molecular Mechanisms of Human Hypertension // 2001. Т. 104. С. 545–556.

33. Lobach L.Y., Dosenko V.Y., Dolzhenko M.M. Gene polymorphism of aldosterone synthetase (CYP11B2) variants and main cardiovascular risk factors // Zaporozhye Med. J. 2016. Т. 0. № 6. С. 4–11.

34. Mehri S. et al.  The CC genotype of the angiotensin II type I receptor gene independently associates with acute myocardial infarction in a Tunisian population // J. Renin-Angiotensin- Aldosterone Syst. 2011. Т. 12 (4). С. 595–600.

35. Mehri S. et al.  Renin-Angiotensin system polymorphisms in relation to hypertension status and obesity in a Tunisian population // Mol. Biol. Rep. 2012. Т. 39. № 4. С. 4059–4065.

36. Miyaki K. et al.  The combined impact of 12 common variants on hypertension in Japanese men, considering GWAS results // J. Hum. Hypertens. 2012. Т. 26. № 7. С. 430–436.

37. Mohana V.U. et al. Gender-related association of AGT gene variants (M235T and T174M) with essential hypertension-A case-control study // Clin. Exp. Hypertens. 2012. Т. 34. № 1. С. 38–44.

38. Munshi A. et al. Corrigendum to “Association of the −344C/T aldosterone synthase (CYP11B2) gene variant with hypertension and stroke” [Journal of the Neurological Sciences 296 (2010) 34–38] // J. Neurol. Sci. 2012. Т. 321. № 1–2. С. 122.

39. Nie S. et al. Haplotype-based case-control study of the human AGTR1 gene and essential hypertension in Han Chinese subjects. // Clin. Biochem. 2010. Т. 43. № 3. С. 253–8.

40. Niu S. et al. Synergistic effects of gene polymorphisms of the renin–angiotensin–aldosterone system on essential hypertension in Kazakhs in Xinjiang // Clin. Exp. Hypertens. 2016. Т. 38. № 1. С. 63–70.

41. Padma G. et al. Risk conferred by tagged SNPs of AGT gene in causing susceptibility to essential hypertension // Clin. Exp. Hypertens. 2014. Т. 36. № 8. С. 579–585.

42. Palatini P. et al. Angiotensin II type 1 receptor gene polymorphism predicts development of hypertension and metabolic syndrome // Am. J. Hypertens. 2009. Т. 22. № 2. С. 208–214.

43. Persu A. Candidate gene studies: accepting negative results. // J. Hypertens. 2006. Т. 24. № 3. С. 443–5.

44. Pi Y. et al. Lack of an Association between CYP11B2 C-344T Gene Polymorphism and Ischemic Stroke: A Meta-Analysis of 7,710 Subjects // PLoS One. 2013. Т. 8. № 8. С. 1–7.

45. Sugimoto K. et al. Association between angiotensin II type 1 receptor gene polymorphism and essential hypertension: the Ohasama Study. // Hypertens. Res. 2004. Т. 27. № 8. С. 551–6.

46. Takeuchi F. et al. Reevaluation of the association of seven candidate genes with blood pressure and hypertension: A replication study and meta-Analysis with a larger sample size // Hypertens. Res. 2012. Т. 35. № 8. С. 825–831.

47. Tamaki, Shinji, Nakamura, Yasuyuki, Tabara, Yasuharu, Okamura, Tomonori, Kanda, Hideyuki, Kita, Yoshikuni, Kadowaki, Takashi, Tsujita, Yasuyuki, Chowdhury Turin, Tanvir, Horie, Minoru. Association between polymorphism of the AGTR1 and cardiovascular events in a Japanese general sample (The Shigaraki Study) // Int. J. Cardiol. 2009. Т. 136. № 3. С. 354–355.

48. Tu Y. et al. Genetic polymorphism of CYP11B2 gene and stroke in the Han Chinese population and a meta-analysis. // Pharmacogenet. Genomics. 2011. Т. 21. № 3. С. 115–20.

49. Watkins W.S. et al. Genotype–phenotype analysis of angiotensinogen polymorphisms and essential hypertension: the importance of haplotypes // J. Hypertens. 2010. Т. 28. № 1. С. 65–75.

50. Wu, Ting-Ting; Adi, Dilare; Zhou Y. Relationships between CYP11B2-344C/T gene polymorphism and coronary artery disease: a meta-analysis // Int. J. Clin. Exp. Med. 2016. Т. 9. № 7. С. 13844–13851.

51. Xi B. et al. Association of polymorphisms in the AGT gene with essential hypertension in the Chinese population // J. Renin-Angiotensin-Aldosterone Syst. 2012. Т. 13. № 2. С. 282–288.

52. Xu H. et al. Association of aldosterone synthase (CYP11B2) -344 T/C polymorphism with diabetic nephropathy: A meta-analysis // J. Renin-Angiotensin-Aldosterone Syst. 2016. Т. 17. № 1. С. 1–6.

53. Yang Y. et al. Correlation between renin-angiotensin system gene polymorphisms and essential hypertension in the Chinese Yi ethnic group // J. Renin-Angiotensin- Aldosterone Syst. 2015. Т. 0. № 0. С. 975 –981.

54. Yu Y. The CYP11B2 -344C/T variant is associated with ischemic stroke risk: An updated meta-analysis. // J. Renin-Angiotensin-Aldosterone Syst. JRAAS. 2015. Т. 16. № 2. С. 382–388.

55. Zotova T.Y. et al. Analysis of Polymorphism of Angiotensin System Genes (ACE, AGTR1, and AGT) and Gene ITGB3 in Patients with Arterial Hypertension in Combination with Metabolic Syndrome // Bull. Exp. Biol. Med. 2016. Т. 161. № 3. С. 334–338.

References:

1. Akilzhanovа A.R., Kozhamkulov U.A., Kairov U.Ye., Rakhimova S.Ye., Akhmetova A.Zh., Yerezhepov D.A., Molkenov A.B., Abilova Zh.M., Zhumadilov Zh.Sh. Issledovanie geneticheskikh variantov, assotsiirovannykh s gipertoniei, ozhireniem i diabetom u lits kazakhskoi populyatsii dlya posleduyushchego izucheniya vzaimosvyazei geneticheskikh variantov i metaboloma [Determination of genetic variants associated with hypertension, obesity and diabetes in kazakh population to study interaction of genetic variants and metabolome]. Nauka i Zdravookhranenie [Science & Healthcare]. 2016, 4, pp. 30-42. [in Russian]

2. Shatskaya E.G., Karpenko M.A., Larionova V.I. Polimorfizm “kandidatnykh” genov i arterial'naya gipertenziya, oslozhnennaya insul'tom [Polymorphism of "candidate" genes and arterial hypertension complicated by stroke]. Vestnik Rossiiskoi voenno-meditsinskoi akademii [Bulletin of the Russian Military Medical Academy]. 2011. T.1. № 33. P. 35-42. [in Russian]

3. Abdollahi M.R. and others Quantitated transcript haplotypes (QTH) of AGTR1, reduced abundance of mRNA haplotypes containing 1166C (rs5186: A> C), and relevance to metabolic syndrome traits. Hum. Mutat. 2007. V. 28. № 4. P. 365-373.

4. Androulakis E. et al. The impact of an aldosterone synthase (CYP11B2) polymorphism on vascular function and inflammatory biomarkers in essential hypertension acc Moderated Poster Contributions. J. Am. Coll. Cardiol. 2012. Vol. 59. No. 13. S. E1634.

5. Becker K.G. and others. The Genetic Association Database. Nat. Genet. 2004. P. 36. № 5. P. 431-432.

6. Behravan J., Naghibi M., Mazloomi M.A.L.I. Polymorphism of angiotensin II type 1receptor gene in Essential Hypertension in Iranian population. DARU. 2006. T. 14. № 2. P. 82-86.

7. Byrd J.B., Auchus R.J., White P.C. Aldosterone Synthase Promoter Polymorphism and Cardiovascular Phenotypes in a Large, Multiethnic Population-Based Study. J. Investig. Med. 2015. P. 63. № 7. P. 862-866.

8. Campbell C.Y. Associations between Genetic Variants in the ACE, AGT, AGTR1 and AGTR2 Genes and Renal Function in the Multi-Ethnic Study of Atherosclerosis. Am. J. Nephrol. 32. № 2. P. 156-162.

9. Chandra S. et al. Atrial natriuretic peptide and aldosterone synthase gene in essential hypertension: A case-control study. Gene. 2015. P. 567. № 1. P. 92-97.

10. Chen J. et al. Lack of association of CYP11B2-344C  T polymorphism with essential hypertension: a meta-analysis. 2015. T. 8. No. 6. P. 9162-9167.

11. Cwynar M. et al. Blood pressure, arterial stiffness and endogenous lithium clearance in relation to AGTR1 A1166C and AGTR2 G1675A gene polymorphisms. J. Renin. Angiotensin. Aldosterone. Syst. 2016. T. 17. № 2. S. 1-12.

12. Dai H.J. and others. T-HOD: A literature-based candidate gene database for hypertension, obesity and diabetes. Database. 2013. S. 1-8.

13. Fabris B, Bortoletto M, Candido R, Barbone F, Cattin MR, Calci M, Scanferla F, Tizzoni L, Giacca M C.R. Genetic polymorphisms of the renin-angiotensin-aldosterone system and renal insufficiency in essential hypertension. J Hypertens. 2005. T. 23 (2). Pp. 309-16.

14. Fatini C. et al., Multilocus analysis in candidate genes ACE, AGT, and AGTR1 and predisposition to peripheral arterial disease: Role of ACE D / -240T haplotype. J. Vasc. Surg. 2009. T. 50. № 6. P. 1399-1404.

15. Fung M.M. et al., Early inflammatory and metabolic changes in association with AGTR1 polymorphisms in prehypertensive subjects. Am. J. Hypertens. 2011. № 2. P. 225-233.

16. Gnickenig G.; Harrison D.G. The AT1-Type Angiotensin Receptor in Oxidative Stress and Atherogenesis Part II: AT1 Receptor Regulation. Circulation. 2002. Vol. 105. S. 530-536.

17. Gatti R.R. and others. The interaction of AGT and NOS3 gene polymorphisms with conventional risk factors increases the predisposition to hypertension. JRAAS-J. Renin-Angiotensin-Aldosterone Syst. 2013. P. 14. № 4. P. 360-368.

18. Gu D. et al. Association Study 33 Single-Nucleotide Polymorphisms in 11 Candidate Genes for Hypertension in Chinese. Hypertension. 2006. No. 1147-1154.

19. Henderson O., Christopher A. W.M. Multiple Polymorphisms in the Renin-Angiotensin-Aldosterone System (ACE, CYP11B2, AGTR1) and Their Contribution to Hypertension in African Americans and Latinos in the Am. J. Med. Sci. 328. № 5. P. 266-273.

20. Herrera C.L. Association of polymorphisms within the Renin-Angiotensin System with metabolic syndrome in a cohort of Chilean subjects. Arch Endocrinol Metab. 2016. Vol. 60. No. 3. P. 190-8.

21. Hsiao C.-F. et al., The effects of the renin-angiotensin-aldosterone system gene polymorphisms on insulin resistance in hypertensive families. J. Renin-Angiotensin-Aldosterone Syst. 2012. T. 13. № 4. P. 446-454.

22. Imaizumi T. et al., Association of Interactions between dietary salt consumption and hypertension-susceptibility genetic polymorphisms with blood pressure among Japanese male workers. Clin. Exp. Nephrol. 2017. Vol. 21. No. 3. S. 457-464.

23. Ji L. et al., The Association between Polymorphisms in the Renin-Angiotensin-Aldosterone System Genes and Essential Hypertension in the Han Chinese Population. PLoS One. 2013. 8. 8. № 8. P. 4-9.

24. Ji L.D. and others. Are genetic polymorphisms in the renin-angiotensin-aldosterone system associated with essential hypertension? Evidence from genome-wide association studies. J. Hum. Hypertens. 2017. V. 31. 11. P. 695-698.

25. Jia M. et al. Computational analysis of the functional single nucleotide polymorphisms associated with the CYP11B2 gene. PLoS One. 2014. T. 9. № 8.

26. Kim Y.R. and others. Association of the K173R variant and haplotypes in the aldosterone synthase gene with essential hypertension. Genes and Genomics. 2014. P. 36. № 5. P. 625-632.

27. Kolovou V. et al. Angiotensinogen (AGT) M235T, AGT T174M and Angiotensin-1-Converting Enzyme (ACE) I / D Gene Polymorphisms in Essential Hypertension: Effects on Ramipril Efficacy. Open Cardiovasc. Med. J. 2015. 9. 9. P. 118-126.

28. Lapierre A.V. Angiotensin II type 1 receptor gene polymorphism and essential hypertension in San Luis. Biocell. 2006. Т. 30. № 3. С. 447–455.

29. Li H. et al. The relationship between angiotensinogen gene polymorphisms and essential hypertension in a Northern Han Chinese population. Angiology. 2014. Т. 65. № 7. С. 614–619.

30. Li X. et al. CYP11B2 gene polymorphism and essential hypertension among Tibetan, Dongxiang and Han populations from northwest of China. Clin. Exp. Hypertens. 2016. Т. 38. № 4. С. 375–380.

31. Li Y.Y. Lack of association of A-6G polymorphism of AGT gene with essential hypertension in the Chinese population. J. Cardiovasc. Med. 2012. Т. 13. № 8. С. 505–510.

32. Lifton R.P. et al. Molecular Mechanisms of Human Hypertension. 2001. Т. 104. С. 545–556.

33. Lobach L.Y., Dosenko V.Y., Dolzhenko M.M. Gene polymorphism of aldosterone synthetase (CYP11B2) variants and main cardiovascular risk factors. Zaporozhye Med. J. 2016. Т. 0. № 6. С. 4–11.

34. Mehri S. et al.  The CC genotype of the angiotensin II type I receptor gene independently associates with acute myocardial infarction in a Tunisian population. J. Renin-Angiotensin- Aldosterone Syst. 2011. Т. 12 (4). С. 595–600.

35. Mehri S. et al.  Renin-Angiotensin system polymorphisms in relation to hypertension status and obesity in a Tunisian population. Mol. Biol. Rep. 2012. Т. 39. № 4. С. 4059–4065.

36. Miyaki K. et al.  The combined impact of 12 common variants on hypertension in Japanese men, considering GWAS results. J. Hum. Hypertens. 2012. Т. 26. № 7. С. 430–436.

37. Mohana V.U. et al. Gender-related association of AGT gene variants (M235T and T174M) with essential hypertension-A case-control study. Clin. Exp. Hypertens. 2012. Т. 34. № 1. С. 38–44.

38. Munshi A. et al. Corrigendum to “Association of the −344C/T aldosterone synthase (CYP11B2) gene variant with hypertension and stroke” [Journal of the Neurological Sciences 296 (2010) 34–38]. J. Neurol. Sci. 2012. Т. 321. № 1–2. С. 122.

39. Nie S. et al. Haplotype-based case-control study of the human AGTR1 gene and essential hypertension in Han Chinese subjects. Clin. Biochem. 2010. Т. 43. № 3. С. 253–8.

40. Niu S. et al. Synergistic effects of gene polymorphisms of the renin–angiotensin–aldosterone system on essential hypertension in Kazakhs in Xinjiang. Clin. Exp. Hypertens. 2016. Т. 38. № 1. С. 63–70.

41. Padma G. et al. Risk conferred by tagged SNPs of AGT gene in causing susceptibility to essential hypertension. Clin. Exp. Hypertens. 2014. Т. 36. № 8. С. 579–585.

42. Palatini P. et al. Angiotensin II type 1 receptor gene polymorphism predicts development of hypertension and metabolic syndrome. Am. J. Hypertens. 2009. Т. 22. № 2. С. 208–214.

43. Persu A. Candidate gene studies: accepting negative results. J. Hypertens. 2006. Т. 24. № 3. С. 443–5.

44. Pi Y. et al. Lack of an Association between CYP11B2 C-344T Gene Polymorphism and Ischemic Stroke: A Meta-Analysis of 7,710 Subjects. PLoS One. 2013. Т. 8. № 8. С. 1–7.

45. Sugimoto K. et al. Association between angiotensin II type 1 receptor gene polymorphism and essential hypertension: the Ohasama Study. Hypertens. Res. 2004. Т. 27. № 8. С. 551–6.

46. Takeuchi F. et al. Reevaluation of the association of seven candidate genes with blood pressure and hypertension: A replication study and meta-Analysis with a larger sample size. Hypertens. Res. 2012. Т. 35. № 8. С. 825–831.

47. Tamaki, Shinji, Nakamura, Yasuyuki, Tabara, Yasuharu, Okamura, Tomonori, Kanda, Hideyuki, Kita, Yoshikuni, Kadowaki, Takashi, Tsujita, Yasuyuki, Chowdhury Turin, Tanvir, Horie, Minoru. Association between polymorphism of the AGTR1 and cardiovascular events in a Japanese general sample (The Shigaraki Study). Int. J. Cardiol. 2009. Т. 136. № 3. С. 354–355.

48. Tu Y. et al. Genetic polymorphism of CYP11B2 gene and stroke in the Han Chinese population and a meta-analysis. Pharmacogenet. Genomics. 2011. Т. 21. № 3. С. 115–20.

49. Watkins W.S. et al. Genotype–phenotype analysis of angiotensinogen polymorphisms and essential hypertension: the importance of haplotypes. J. Hypertens. 2010. Т. 28. № 1. С. 65–75.

50. Wu, Ting-Ting; Adi, Dilare; Zhou Y. Relationships between CYP11B2-344C/T gene polymorphism and coronary artery disease: a meta-analysis. Int. J. Clin. Exp. Med. 2016. Т. 9. № 7. С. 13844–13851.

51. Xi B. et al. Association of polymorphisms in the AGT gene with essential hypertension in the Chinese population. J. Renin-Angiotensin-Aldosterone Syst. 2012. Т. 13. № 2. С. 282–288.

52. Xu H. et al. Association of aldosterone synthase (CYP11B2) -344 T/C polymorphism with diabetic nephropathy: A meta-analysis. J. Renin-Angiotensin-Aldosterone Syst. 2016. Т. 17. № 1. С. 1–6.

53. Yang Y. et al. Correlation between renin-angiotensin system gene polymorphisms and essential hypertension in the Chinese Yi ethnic group. J. Renin-Angiotensin- Aldosterone Syst. 2015. Т. 0. № 0. С. 975 –981.

54. Yu Y. The CYP11B2 -344C/T variant is associated with ischemic stroke risk: An updated meta-analysis. J. Renin-Angiotensin-Aldosterone Syst. JRAAS. 2015. Т. 16. № 2. С. 382–388.

55. Zotova T.Y. et al. Analysis of Polymorphism of Angiotensin System Genes (ACE, AGTR1, and AGT) and Gene ITGB3 in Patients with Arterial Hypertension in Combination with Metabolic Syndrome. Bull. Exp. Biol. Med. 2016. Т. 161. № 3. С. 334–338.



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Библиографиялық сілтемелер

Шаханова А.Т., Аукенов Н.Е., Нуртазина А.У. Полиморфизмы генов при артериальной гипертензии: ренин – ангиотензин – альдостероновая система. Обзор литературы / / Наука и Здравоохранение. 2018. №1. С. 116-130.

Shakhanova A.Т., Aukenov N.E., Nurtazina A.U. Polymorphisms of genes in hypertension: renin - angiotensin - aldosterone system: a review. Nauka i Zdravookhranenie [Science & Healthcare]. 2018, 1, pp. 116-130.

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