СОВРЕМЕННОЕ ПРЕДСТАВЛЕНИЕ О МОЛЕКУЛЯРНЫХ МЕХАНИЗМАХ ДЕЙСТВИЙ МЕТФОРМИНА
Обзор посвящен анализу молекулярных механизмов действия метформина, широко применяемого во всем мире, антидиабетического средства. Кроме гипогликемического действия у метформина обнаружен ряд плейотропных эффектов, в частности противоопухолевый. <span style="border-width: 1pt; border-color: windowtext;">Эффект метформина на пролиферацию раковых клеток связан с активацией AMPK и угнетением </span><span style="border-width: 1pt; border-color: windowtext;">mTOR</span><span style="border-width: 1pt; border-color: windowtext;">, который иг...
Толығырақ
2015 жыл | Шығарылым: 2 | Беттер: 19-29
ПОПЕРЕЧНЫЕ (ОДНОМОМЕНТНЫЕ) ИССЛЕДОВАНИЯ В ЗДРАВООХРАНЕНИИ
В настоящей работе представлены основные принципы планирования, проведения и статистической обработки данных поперечных (одномоментных) исследований в здравоохранении. Приведены практические примеры расчета размера выборки и оценки связи между факторами риска с помощью онлайн-калькуляторов и пакета для обработки эпидемиологических данных Epi Info. Авторы представляют практические примеры использования поперечных исследований в литературе, а также достоинства и недостатки данного типа исследований. Настоящая статья призвана дать общие сведения о поперечных исследованиях, и не заменяет п...
Толығырақ
2015 жыл | Шығарылым: 2 | Беттер: 5-18
ХИРУРГИЧЕСКОЕ ЛЕЧЕНИЕ ВНУТРИМОЗГОВЫХ КРОВОИЗЛИЯНИЙ У БЕРЕМЕННЫХ ЖЕНЩИН
Возникновение неотложных нейрохирургических
состояний у беременных женщин является сложной мультидисциплинарной проблемой,
для решения которой требуется участие специалистов нескольких смежных
специальностей.
Толығырақ
2015 жыл | Шығарылым: 1 | Беттер: 77-80
МОДЕЛЬ УПРАВЛЕНИЯ МОТИВАЦИЕЙ МЕДИЦИНСКОГО ПЕРСОНАЛА НА ПРИМЕРЕ РЕГИОНАЛЬНОГО ОНКОЛОГИЧЕСКОГО ДИСПАНСЕРА ГОРОДА СЕМЕЙ
В статье представлена модель мотивационного управления медицинским персоналом Регионального онкологического диспансера г. Семей, на базе которого находится кафедра онкологии и радиологии медицинского университета имени д.м.н., профессора Д.Р. Мусинова и проходят обучение по программе резидентура, магистратура, Phd докторантура. Мотивация персонала освещена в свете реализации Программы развития онкологической помощи на 2012-2016 года, включая развитие ядерной медицины. Создание высокоэффективных и мотивированных команд, в том числе и в лечебно-профилактических учреждениях, позволит повысить про...
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2015 жыл | Шығарылым: 1 | Беттер: 70-76
СОСТОЯНИЕ КОАГУЛЯЦИОННОГО ЗВЕНА ГЕМОСТАЗА У ЖЕНЩИН ГРУППЫ РИСКА ПРИ ПОСЛЕРОДОВЫХ КРОВОТЕЧЕНИЯХ В ЗАВИСИМОСТИ ОТ ПАРИТЕТА РОДОВ
Акушерские кровотечения остаются актуальной проблемой современного акушерства и занимают ведущее место в структуре материнской смертности во многих странах мира. Немалый вклад в летальные исходы от данной патологии в Республике Казахстан вносят многорожавшие женщины. Более 2/3 кровопотерь, в том числе угрожающих жизни матери, связано с нарушениями в системе гемостаза.
Толығырақ
2015 жыл | Шығарылым: 1 | Беттер: 60-69
COMPARATIVE EVALUATION OF BLOOD COLLECTION TUBES AND EXTRACTION METHODS FOR CIRCULATING TUMOR DNA
2025 жыл | Шығарылым: 6 | Беттер: 7-13
INFLUENCE OF SEX HORMONE-BINDING GLOBULIN (SHBG) ON THE LEVEL OF FREE TESTOSTERONE FRACTION IN OLDER OVERWEIGHT MEN
2025 жыл | Шығарылым: 6 | Беттер: 14-20
ASSESSMENT OF THE PROBABILITY OF DEVELOPING CARDIORENAL SYNDROME TYPE 2 DEPENDING ON POTENTIAL BIOMARKERS IN PEDIATRIC PATIENTS
2025 жыл | Шығарылым: 6 | Беттер: 21-29
MORPHO-GENETIC VARIABILITY IN MYOCARDIAL TISSUE AFTER SEPTAL MYECTOMY IN PATIENTS WITH OBSTRUCTIVE HYPERTROPHIC CARDIOMYOPATHY: A FOUR-CASE SERIES STUDY
2025 жыл | Шығарылым: 6 | Беттер: 30-37
CLINICAL EFFICACY OF SELECTIVE PLASMA FILTRATION (EVACLIO) IN CARDIOVASCULAR COMPLICATIONS: A CASE SERIES FROM THE HEART CENTER KAZAKHSTAN
2025 жыл | Шығарылым: 6 | Беттер: 38-46
ANALYSIS OF QUANTITATIVE DATA IN TWO NON-INDEPENDENT GROUPS USING STATISTICA AND SPSS SOFTWARE: PARAMETRIC AND NON-PARAMETRIC TESTS
In this article we present general information about Student’s paired t-test, non-parametric Wilcoxon test for paires samples and sign test which are often used for comparing paired numerical data. Algoritms for the use of all abovementioned criteria using Statistica 10 and SPSS 20 software are presented as well as recommendations on how to interpret results of the tests. This article covers basic knowledge needed for practical implementation of tests for paired observations (continuopus data) and does not substitute reading specialized literature in biostatistics and clinical epidemio...
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2016 жыл | Шығарылым: 3 | Беттер: 5-25
THE COMPARATIVE ANALYSIS OF DISTRIBUTION OF WORKING HOURS AT THE STAFF OF THE SURGICAL DEPARTMENT USING MEDICAL INFORMATION SYSTEM
Optimization of activity of staff of medical institutions, including surgical departments, is an integral part of reforming of health system. One of the important directions is the informatization realized by means of development and operation of medical information systems.
Research objective – the comparative analysis of distribution of working hours at the staff of surgical departments which are carrying out and not carrying out use of medical information system.
Materials and methods. Within work questioning and monitoring of working hours of 74 doctors-surgeons, including 55 –... Толығырақ
Research objective – the comparative analysis of distribution of working hours at the staff of surgical departments which are carrying out and not carrying out use of medical information system.
Materials and methods. Within work questioning and monitoring of working hours of 74 doctors-surgeons, including 55 –... Толығырақ
2016 жыл | Шығарылым: 2 | Беттер: 150-161
COMMITMENT TO HEALTHY LIFESTYLES OF HIGH SCHOOL AND COLLEGE STUDENTS
Human health is one of the global problems of modern society, beyond medical science and practice. In recent years there has been an increased incidence among young people. One of the causes this trend is the lack of young people adequate training and experience of leading a healthy lifestyle. Young people satisfied with their health and is ready to lead a healthy lifestyle, but the general culture of a healthy lifestyle in the minds of young people have not yet formed
The purpose of research - the study of the social and personal aspects of young people's early adolescence, analysis... Толығырақ
The purpose of research - the study of the social and personal aspects of young people's early adolescence, analysis... Толығырақ
2016 жыл | Шығарылым: 2 | Беттер: 139-149
THE PREVALENCE OF REFRACTIVE ERRORSAMONG THE FIRST-YEAR STUDENTS OF SEMEY STATE MEDICAL UNIVERSITY
Background.Myopia is a high prevalent eye disease in the word and is a common cause of visionloss. Increasing myopiaprevalence among young population, including the students of medical universities, has raises scientific interest for this problem.
The aim of the study is to examine the prevalence of refractive errors among the first year medical students and to compare it with the World indicators.
Methods: A cross-sectional study including 598 students (1195 eyes). All the first year students, excluding the foreign students, have been examined. The statistically significan... Толығырақ
The aim of the study is to examine the prevalence of refractive errors among the first year medical students and to compare it with the World indicators.
Methods: A cross-sectional study including 598 students (1195 eyes). All the first year students, excluding the foreign students, have been examined. The statistically significan... Толығырақ
2016 жыл | Шығарылым: 2 | Беттер: 129-138
THE EXPERIENCE OF CORRECTION OF VASCULAR ENDOTHELIAL FUNCTION AND HEMOSTASIS IN PATIENTS WITH RECTAL CANCER
A valuable trend in modern oncology it is improving the conservative treatment of rectal cancer, as one of the most common and dangerous form of malignancies
The purpose of the research – identifying of opportunities for correction of endothelial dysfunction in patients with rectal cancer and assessment of its impact on the state of the hemostatic system and the risk of thrombotic complications.
Materials and methods. The study included 86 patients with rectal cancer, including 45 men (52.3%), 41 women (47.7%) aged 45 to 70 years (mean age 62,3±1,8 year... Толығырақ
The purpose of the research – identifying of opportunities for correction of endothelial dysfunction in patients with rectal cancer and assessment of its impact on the state of the hemostatic system and the risk of thrombotic complications.
Materials and methods. The study included 86 patients with rectal cancer, including 45 men (52.3%), 41 women (47.7%) aged 45 to 70 years (mean age 62,3±1,8 year... Толығырақ
2016 жыл | Шығарылым: 2 | Беттер: 118-128