ВЛИЯНИЕ ОТДАЛЕННЫХ ПОСЛЕДСТВИЙ ОСТРОГО ГАММА-ИЗЛУЧЕНИЯ И ЭМОЦИОНАЛЬНОГО СТРЕССА НА ФУНКЦИОНАЛЬНОЕ СОСТОЯНИЕ КОСТНОГО МОЗГА И ТИМУСА
В раннем периоде общего адаптационного синдрома снижается масса тимуса, повышается количество лимфо-идных клеток, в последующей стадии в тимусе возрастает масса и нормализуется число лимфоидных клеток. Во всех фазах адаптационного синдрома в костном мозге происходит повышение лимфоидных клеток.
Толығырақ
2014 жыл | Шығарылым: 4 | Беттер: 62-65
ОТДАЛЕННЫЕ ЭФФЕКТЫ РАЗНОЙ ДОЗЫ ГАММА-ИЗЛУЧЕНИЯ НА ЛИМФОИДНЫЕ ОРГАНЫ ИММУНОГЕНЕЗА
В отдаленном периоде после сублетального и фракционированного действия гамма-излучения в тимусе и лим-фатических узлах тонкого кишечника снижены количества лимфоидных клеток. В тимусе и селезенке определяется атрофия, в лимфатических узлах тонкого кишечника - сниженный лимфоидный индекс и лимфоидных клеток.
В отдаленном периоде после воздействия малой дозы гамма-излучения отмечается атрофия тимуса и перерас-пределение лимфоидных клеток из тимуса и лимфатических узлов тонкого кишечника в костный мозг и селезенку.
Толығырақ
В отдаленном периоде после воздействия малой дозы гамма-излучения отмечается атрофия тимуса и перерас-пределение лимфоидных клеток из тимуса и лимфатических узлов тонкого кишечника в костный мозг и селезенку.
Толығырақ
2014 жыл | Шығарылым: 4 | Беттер: 49-53
DENTAL STATUS OF PATIENTS DURING THE SUPPORTIVE CARE AT ANTINEOPLASTIC CHEMOTHERAPY FOR BREAST CANCER
Two groups were studied in a comparative aspect – 98 women with breast cancer during the courses of adjuvant chemo-therapy: the first was comprised of 26 patients who used their conventional means for oral hygiene; the second included 72 patients, who received the complex of therapeutic and preventive measures of supportive care. Dental toxicity was observed in 84.6-96.2 %, and has grown with the increase of the cycles of chemotherapy, reaching a maximum value on the V cycle of treatment. It is shown that the application of the developed complex significantly reduces the manifestations of ...
Толығырақ
2014 жыл | Шығарылым: 4 | Беттер: 35-39
ДАННЫЕ СКРИНИНГА ПАТОЛОГИИ ЩИТОВИДНОЙ ЖЕЛЕЗЫ У ЖИТЕЛЕЙ РАЙОНОВ, ПОДВЕРГШИХСЯ РАДИАЦИОННОМУ ОБЛУЧЕНИЮ
В статье приведены данные, полученные в результате скрининга населения районов, подвергшихся радиационному облучению. Целью исследования было выявление частоты и особенностей патологии щитовидной железы у жителей районов Павлодарской и Восточно-Казахстанской областей, подвергшиеся радиационному облучению. Обследовано 1783 человека. Диффузный эутиреоидный зоб диагностирован в 32,97% случаев, колло-идно-узловой зоб у 13,60% обследованных, аутоиммуный тиреоидит у 52,96%, в 2,4% случаев наблюдался много-узловой зоб. Анализ функционального состояния щитовидной железы пока...
Толығырақ
2014 жыл | Шығарылым: 3 | Беттер: 22-25
МОДЕЛИРОВАНИЕ САХАРНОГО ДИАБЕТА 2 ТИПА ДЛЯ ИЗУЧЕНИЯ ЛЕКАРСТВЕННЫХ СРЕДСТВ С АНТИДИАБЕТИЧЕСКОЙ АКТИВНОСТЬЮ
Учитывая неуклонно возрастающее во всем мире число больных сахарным диабетом 2 типа, актуальной проблемой современной фармакологии продолжает оставаться разработка антидиабетических препаратов, обладающих высокой терапевтической активностью и имеющих более совершенный профиль безопасности. В связи с этим важное значение имеет моделирование сахарного диабета, позволяющее достоверно выявлять наличие той или иной фармакологической активности или новых деталей в механизме действия лекарственных средств. Модели сахарного диабета могут быть получены на различных видах животных ...
Толығырақ
2014 жыл | Шығарылым: 4 | Беттер: 4-8
COMPARATIVE EVALUATION OF BLOOD COLLECTION TUBES AND EXTRACTION METHODS FOR CIRCULATING TUMOR DNA
2025 жыл | Шығарылым: 6 | Беттер: 7-13
INFLUENCE OF SEX HORMONE-BINDING GLOBULIN (SHBG) ON THE LEVEL OF FREE TESTOSTERONE FRACTION IN OLDER OVERWEIGHT MEN
2025 жыл | Шығарылым: 6 | Беттер: 14-20
ASSESSMENT OF THE PROBABILITY OF DEVELOPING CARDIORENAL SYNDROME TYPE 2 DEPENDING ON POTENTIAL BIOMARKERS IN PEDIATRIC PATIENTS
2025 жыл | Шығарылым: 6 | Беттер: 21-29
MORPHO-GENETIC VARIABILITY IN MYOCARDIAL TISSUE AFTER SEPTAL MYECTOMY IN PATIENTS WITH OBSTRUCTIVE HYPERTROPHIC CARDIOMYOPATHY: A FOUR-CASE SERIES STUDY
2025 жыл | Шығарылым: 6 | Беттер: 30-37
CLINICAL EFFICACY OF SELECTIVE PLASMA FILTRATION (EVACLIO) IN CARDIOVASCULAR COMPLICATIONS: A CASE SERIES FROM THE HEART CENTER KAZAKHSTAN
2025 жыл | Шығарылым: 6 | Беттер: 38-46
COMMENTS ON 2016 EUROPEAN GUIDELINES FOR THE MANAGEMENT OF ATRIAL FIBRILLATION: NEW ASPECTS FOR PHYSICIANS
Updated European guidelines for the management of atrial fibrillation were published on the 27 of August, 2016. This document is remarkable for new recommendations, especially about anticoagulation therapy. Key points of these guidelines and the possibility of their use in our country are described in the article.
Objective: to find out essential evidence-based key points of the 2016 guidelines and to investigate the possibility of their use in Kazakhstan.
Materials and methods: To achieve these goals major differences between 2016, 2012, 2010 guidelines were analyze... Толығырақ
Objective: to find out essential evidence-based key points of the 2016 guidelines and to investigate the possibility of their use in Kazakhstan.
Materials and methods: To achieve these goals major differences between 2016, 2012, 2010 guidelines were analyze... Толығырақ
2017 жыл | Шығарылым: 1 | Беттер: 74-86
IMMUNOHISTOCHEMICAL ANALYSIS EXPRESSION TP73 IN ONCOCYTIC FOLLICULAR ADENOMA OF THE THYROID
Oncocytic follicular adenomas (FAs) of the thyroid are cells neoplasms of follicular origin that predominantly consist of large polygonal cells with eosinophilic and granular cytoplasm. According to some scientific studies, TP73 might play a сertain role in tumor genesis (oncogenesis). Moreover, due to the absence of p53, oncogenes may attract p73 to induce apoptosis in tumor cells. TP53 is a crucial tumor suppressor in preventing the cancerous transformation of cells. There was also a particular focus on the amplification of 1p36 chromosome in oncocytic FA, which contains a t...
Толығырақ
2017 жыл | Шығарылым: 1 | Беттер: 64-73
ASSESSMENT OF TOXICITY OF NEOADJUVANT CHEMOTHERAPY FOR LOCALLY ADVANCED BREAST CANCER
Introduction. In the structure of malignancies in women breast cancer (BC) takes 1st place. In locally advanced breast cancer (LABC) treatment begins with neoadjuvant chemotherapy (CTX), the standard protocols are CMF, FAC, AC. In the trial, we used cytostatic Arglabin isolated from plants endemic to Central Kazakhstan - wormwood smooth, as monotherapy and as addition to AC-protocol.
The objective of the trial - to assess the toxicity of different protocols of neoadjuvant CTX of LABC.
Methods: 93 patients with LABC (T2N1-2M0, T3N0-2M0) ... Толығырақ
The objective of the trial - to assess the toxicity of different protocols of neoadjuvant CTX of LABC.
Methods: 93 patients with LABC (T2N1-2M0, T3N0-2M0) ... Толығырақ
2017 жыл | Шығарылым: 1 | Беттер: 52-63
CLINICAL EVALUATION OF THE EFFICIENCY OF ORTHOPEDIC TREATMENT OF PATIENTS WITH EDENTULOUS JAWS WITH COMPLETE REMOVABLE DENTURES USING C-SILICONE MATERIALS FOR FUNCTIONAL IMPRESSIONS
Introduction. Prosthetics of edentulous jaw is one of the most difficult sections of prosthetic dentistry for many years. The difficulty lies in the production of functionally effective complete dentures that are in direct proportion to their fixation on the jaws, stabilization during chewing and even distribution of pressure on the underlying tissues.
The aim of this research was to conduct a comparative clinical evaluation of the efficiency of the complete removable laminar dentures that were made with use of the new materials for functional impressions.
Methods. At... Толығырақ
The aim of this research was to conduct a comparative clinical evaluation of the efficiency of the complete removable laminar dentures that were made with use of the new materials for functional impressions.
Methods. At... Толығырақ
2017 жыл | Шығарылым: 1 | Беттер: 37-51
CORRELATION ANALYSIS OF DATA USING STATISTICA AND SPSS SOFTWARE
In this paper we present the main principles of correlation analysis using parametric and non-parametric methods. Algorithms for calculations of Pearson’s, Spearmen’s and Kendall’s coefficients using Statistica 10 and SPSS 20 software are presented. Special emphasis is given to interpretation of results of statistical analysis. The article complements, but does not substitute specialized literature on biostatistics and clinical epidemiology.
Толығырақ
2017 жыл | Шығарылым: 1 | Беттер: 7-36