ОТДАЛЕННЫЕ ЭФФЕКТЫ МАЛОЙ ДОЗЫ ГАММА-ИЗЛУЧЕНИЯ НА ЛИМФОИДНЫЕ ОРГАНЫ ИММУНОГЕНЕЗА
В отдаленном периоде после воздействия малой дозы гамма-излучения отмечается атрофия тимуса и пере-распределение лимфоидных клеток в костный мозг и селезенку из тимуса и лимфатических узлов тонкого кишечника.
Толығырақ
2014 жыл | Шығарылым: 4 | Беттер: 46-48
CОСТОЯНИЕ СЕЛЕЗЕНКИ И ЛИМФАТИЧЕСКИХ УЗЛОВ ТОНКОГО КИШЕЧНИКА В ПОЗДНЕМ ПЕРИОДЕ ПОСЛЕ ВОЗДЕЙСТВИЯ СУБЛЕТАЛЬНОЙ ДОЗЫ ГАММА-ИЗЛУЧЕНИЯ И ЭМОЦИОНАЛЬНОГО СТРЕССА
Изменения происходящее в периферических лимфоидных органах отражают миграционную способность лимфоидных клеток на ранних стадиях общего адаптационного синдрома в сторону центральных лимфоидных органов.
Толығырақ
2014 жыл | Шығарылым: 4 | Беттер: 53-56
ОСОБЕННОСТИ АДАПТАЦИИ КЛЕТОЧНОГО ИММУНИТЕТА В ОТДАЛЕННОМ ПЕРИОДЕ ПОСЛЕ ДЕЙСТВИЯ ФРАКЦИОНИРОВАННОЙ ДОЗЫ ГАММА-ИЗЛУЧЕНИЯ
В эксперименте изучены особенности адаптации клеточного иммунитета в отдаленном периоде после воздействия фракционированного гамма-излучения
Толығырақ
2014 жыл | Шығарылым: 4 | Беттер: 56-59
ОТДАЛЕННЫЕ ЭФФЕКТЫ ПОСЛЕ ФРАКЦИОНИРОВАННОГО ГАММА-ИЗЛУЧЕНИЯ И ЭМОЦИОНАЛЬНОГО СТРЕССА НА НЕСПЕЦИФИЧЕСКУЮ ФАГОЦИТАРНУЮ РЕЗИСТЕНТНОСТЬ ОРГАНИЗМА
Аннотация
В отдаленном периоде после фракционированного гамма-облучения во всех стадиях адаптационного синдрома происходят повышение неспецифического фагоцитарного звена иммунитета.
Толығырақ
В отдаленном периоде после фракционированного гамма-облучения во всех стадиях адаптационного синдрома происходят повышение неспецифического фагоцитарного звена иммунитета.
Толығырақ
2014 жыл | Шығарылым: 4 | Беттер: 59-62
МОЛЕКУЛЯРНО-ГЕНЕТИЧЕСКИЕ ОСНОВЫ ДИАГНОСТИКИ И ЛЕЧЕНИЯ ИШЕМИЧЕСКОЙ БОЛЕЗНИ СЕРДЦА. (ОБЗОР ЛИТЕРАТУРЫ)
В Республике Казахстан болезни системы кровообращения представляют одну из самых актуальных проблем здравоохранения и занимают одно из ведущих мест в структуре смертности населения [1, 3]. В основе развития мультифакториальных заболеваний, в том числе и сердечно-сосудистых заболеваний (ССЗ) лежат генетические нарушения, как наследственно-приобретенные, обусловливающие индивидуальную предрасположенность к развитию заболевания и приобретенные индивидуумом в результате воздействия внешних факторов среды [20]. Большая часть таких генетических нарушений представлена точечными мутациями (...
Толығырақ
2014 жыл | Шығарылым: 3 | Беттер: 4-11
COMPARATIVE EVALUATION OF BLOOD COLLECTION TUBES AND EXTRACTION METHODS FOR CIRCULATING TUMOR DNA
2025 жыл | Шығарылым: 6 | Беттер: 7-13
INFLUENCE OF SEX HORMONE-BINDING GLOBULIN (SHBG) ON THE LEVEL OF FREE TESTOSTERONE FRACTION IN OLDER OVERWEIGHT MEN
2025 жыл | Шығарылым: 6 | Беттер: 14-20
ASSESSMENT OF THE PROBABILITY OF DEVELOPING CARDIORENAL SYNDROME TYPE 2 DEPENDING ON POTENTIAL BIOMARKERS IN PEDIATRIC PATIENTS
2025 жыл | Шығарылым: 6 | Беттер: 21-29
MORPHO-GENETIC VARIABILITY IN MYOCARDIAL TISSUE AFTER SEPTAL MYECTOMY IN PATIENTS WITH OBSTRUCTIVE HYPERTROPHIC CARDIOMYOPATHY: A FOUR-CASE SERIES STUDY
2025 жыл | Шығарылым: 6 | Беттер: 30-37
CLINICAL EFFICACY OF SELECTIVE PLASMA FILTRATION (EVACLIO) IN CARDIOVASCULAR COMPLICATIONS: A CASE SERIES FROM THE HEART CENTER KAZAKHSTAN
2025 жыл | Шығарылым: 6 | Беттер: 38-46
RNA SEQUENCING OF SQUAMOUS ESOPHAGEAL CANCER: FROM THE COLLECTION OF THE BIOMATERIAL UNTIL SEQUENCING ON HISEQ2000
The squamous esophageal cancer is a disease which is highly frequent in Kazakhstan, the frequency of the disease is 10,1:100 000. In the mortality structure esophageal cancer takes place among men the 5th place, among women the 9th place in the Republic of Kazakhstan. The molecular mechanisms which contribute to the initiation and progression of the cancer pathology are not investigated enough. Nevertheless, the lack of the sensitive and specific biomarkers for the diagnosis of the cancer diseases, underlines about the necessity of the additional research works to study about the development o...
Толығырақ
2016 жыл | Шығарылым: 5 | Беттер: 53-63
DEVELOPMENT OF HALOPLEX PANEL AND PREPARATION OF DNA LIBRARIES FOR TARGETED SEQUENCING OF CARDIAC ARRHYTHMIAS
Method of preparation of custom HaloPlex cardiogenetic panel (Agilent Technologies) and method of preparation of DNA libraries for targeted sequencing of 96 genes associated with cardiac arrhythmias were described in details in this article. SureDesign Online Design software (Agilent Technologies) was used to create the HaloPlex panel. Final design was developed for Illumina platform using Human Genome version 19, GRCh 37. 19958 amplicons were generated by the program, 99,46% of all target regions were covered successfully. DNA libraries were prepared for 48 samples using t...
Толығырақ
2016 жыл | Шығарылым: 5 | Беттер: 43-52
DETERMINATION OF GENETIC VARIANTS ASSOCIATED WITH HYPERTENSION, OBESITY AND DIABETES IN KAZAKH POPULATION TO STUDY INTERACTION OF GENETIC VARIANTS AND METABOLOME
In this work genetic variants associated with hypertension, obesity and diabetes were characterized, and genomic data of 60 samples were compared using Т-HOD (The Text-mined Hypertension, Obesity and Diabetes candidate gene database (T-HOD) international database.
Genetic variants extracted from whole genomes and exomes, and associated with hypertension, obesity and diabetes based on PolyPhen2 and SIFT algorithmic predictors of mutation pathogenicity were analyzed. Seven genetic variants were detected in GHRL (rs4684677), MTHFR (rs1801133), OPRM1 (rs17999... Толығырақ
Genetic variants extracted from whole genomes and exomes, and associated with hypertension, obesity and diabetes based on PolyPhen2 and SIFT algorithmic predictors of mutation pathogenicity were analyzed. Seven genetic variants were detected in GHRL (rs4684677), MTHFR (rs1801133), OPRM1 (rs17999... Толығырақ
2016 жыл | Шығарылым: 5 | Беттер: 30-42
REPORT ABOUT THE CONFERENCE: THE INTERNATIONAL WОRLD HEALTH ORGANIZATION CONSULTATION ON NUTRITION AND PREGNANCY (27-28 June 2016, RIGA, LATVIA)
27-28 June 2016, Riga, Latvia hosted the International WHO consultation on nutrition and pregnancy, with participation of experts in the field of maternal and child health and the WHO Collaborating Centers from Poland, Latvia, Lithuania, Estonia, Italy, the UK, Kazakhstan, Tajikistan, Uzbekistan, Kyrgyzstan, Georgia, Armenia and Moldova. The key problems of women's health and nutrition, according to speakers from different countries are the following: the growth of overweight and obesity among women, excessive weight gain during pregnancy, low rates of exclusive breastfeeding in the first ...
Толығырақ
2016 жыл | Шығарылым: 4 | Беттер: 166-172
MODERN LAVAGE OF THE GASTROINTESTINAL TRACT FROM THE PERSPECTIVE OF THE QUALITY OF DIAGNOSIS AND TREATMENT IN ENDOSCOPIC, BARIATRIC SURGERY (LITERATURE REVIEW)
Introduction. The issue of quality lavage for the gastrointestinal tract before an abdominal surgery and endoscopic examination is of paramount significance, especially in patients with visceral obesity.
The aim of the study is to study historical aspects of intestinal cleansing, identify optimal ways to lavage and define its tolerability by patients.
Research methods. The review examines the effectiveness of different lavage techniques and patients’ preparation before surgeries and endoscopic examinations. The analysis of 77 sources relevant to the results of the study is also inc... Толығырақ
The aim of the study is to study historical aspects of intestinal cleansing, identify optimal ways to lavage and define its tolerability by patients.
Research methods. The review examines the effectiveness of different lavage techniques and patients’ preparation before surgeries and endoscopic examinations. The analysis of 77 sources relevant to the results of the study is also inc... Толығырақ
2016 жыл | Шығарылым: 4 | Беттер: 145-165