MODELING OF TYPE 2 DIABETES MELLITUS IS A NECESSARY FOUNDATION FOR STUDY OF MEDICINAL PRODUCTS WITH ANTIDIABETIC POTENCY
Жалпы бейімделу синдромы ерте кезеңінде лимфоидты жасушалардың саны жоғарылап, тимустың салмағы төмендейді, келесі кезеңде тимустың салмағы жоғарылап және лимфоидты жасуша саны тұрақтанады. Бейімделу синдромының барлық фазаларында сүйек кемігінде лимфоидты жасушалар жоғарылайды.
Толығырақ
2014 жыл | Шығарылым: 4 | Беттер: 4-8
FEATURES OF ADAPTATION OF CELLULAR IMMUNITY IN LATE PERIOD AFTER INFLUENCE OF FRACTIONAL DOSE OF GAMMA-IRRADIATION
Бейімделу синдромының барлық кезеңдерінде фракциональдық гамма – сәуле әсерінен алшақ кезеңде иммундық жүйенің арнайы емес фагоцитарлы буынның төзімділігінің артуы анықталды.
Толығырақ
2014 жыл | Шығарылым: 4 | Беттер: 59-62
FEATURES OF ADAPTATION OF CELLULAR IMMUNITY IN LATE PERIOD AFTER INFLUENCE OF FRACTIONAL DOSE OF GAMMA-IRRADIATION
Экспериментте фракциональдық гамма – сәуленің әсерінен алшақ кезеңде жасушалық иммунитеттің бейімделу ерекшеліктері зерттелді.
Толығырақ
2014 жыл | Шығарылым: 4 | Беттер: 56-59
CONDITION OF SPLEEN AND LYMPHATIC NODES OF SMOLL INTESTINE IN LATE PERIOD AFTER INFLUENCE OF SUBLETAL DOZE OF GAMMA-IRRADIATION AND EMOTIONAL STRESS
Перифериялық лимфоидты ағзаларда жүретін өзгерістер жалпы бейімделу синдромының ерте кезеңдерінде орталық лимфоидты ағзаларға лимфоидты жасушалардың көшу қабылеттілігі көрсетіледі.
Толығырақ
2014 жыл | Шығарылым: 4 | Беттер: 53-56
LATE EFFECTS OF SMOLL DOZE OF GAMMA-IRRADIATION FOR LYMPHOID ORGANS
Гамма – сәуленің шағын дозасының әсерлерінен алшақ кезеңде тимустың атрофиясы және жіңішке ішектің лимфалық түйіндерінен сүйек миына және көкбауырға лимфоидты жасушалардың қайта бөлінуі белгілі болды.
Толығырақ
2014 жыл | Шығарылым: 4 | Беттер: 49-53
IMPACT OF ERYTHROCYTES ANTIGENS ON DEVELOPMENT OF LIVER CIRRHOSIS
Introduction. High rates of prevalence and mortality of liver cirrhosis, it’s late clinical manifestation, disadvantages of liver biopsy highlight the background points of our research.
Aim. Research of erythrocytes’ antigens profile in patients with liver cirrhosis of Kazakh and Russian ethnical groups.
Materials and Methods: One hundred and forty patients with liver cirrhosis and 272 relatively healthy participants of both of nationalities were involved into research. АВ0, MNS, P1, CDE systems of erythrocytes of venous blood were investigated. For the comparison of the frequenc... Толығырақ
Aim. Research of erythrocytes’ antigens profile in patients with liver cirrhosis of Kazakh and Russian ethnical groups.
Materials and Methods: One hundred and forty patients with liver cirrhosis and 272 relatively healthy participants of both of nationalities were involved into research. АВ0, MNS, P1, CDE systems of erythrocytes of venous blood were investigated. For the comparison of the frequenc... Толығырақ
2016 жыл | Шығарылым: 5 | Беттер: 80-89
PSYCHOTHERAPEUTIC REHABILITATION AND NORMALIZATION OF PSYCHOEMOTIONAL AND FUNCTIONAL CONDITION OF PATIENTS WITH PAIN SYNDROMES IN BRAIN ORGANIC LESIONS
Background. Psychoemotional violations impede adequate recovery of neurological function in patients with pain syndromes on a background of central nervous system, enhance their social and domestic roles, as well as substantially reduce the quality of life in patients.
Aim: to increase the efficiency of the rehabilitation of patients with pain syndromes on a background of organic defeat CNS.
Methods. The study has a prospective, comparative open character. The results of psychological rehabilitation were analyzed in 500 patients with stroke, head injury and suffering pain syndromes... Толығырақ
Aim: to increase the efficiency of the rehabilitation of patients with pain syndromes on a background of organic defeat CNS.
Methods. The study has a prospective, comparative open character. The results of psychological rehabilitation were analyzed in 500 patients with stroke, head injury and suffering pain syndromes... Толығырақ
2016 жыл | Шығарылым: 5 | Беттер: 64-79
RNA SEQUENCING OF SQUAMOUS ESOPHAGEAL CANCER: FROM THE COLLECTION OF THE BIOMATERIAL UNTIL SEQUENCING ON HISEQ2000
The squamous esophageal cancer is a disease which is highly frequent in Kazakhstan, the frequency of the disease is 10,1:100 000. In the mortality structure esophageal cancer takes place among men the 5th place, among women the 9th place in the Republic of Kazakhstan. The molecular mechanisms which contribute to the initiation and progression of the cancer pathology are not investigated enough. Nevertheless, the lack of the sensitive and specific biomarkers for the diagnosis of the cancer diseases, underlines about the necessity of the additional research works to study about the development o...
Толығырақ
2016 жыл | Шығарылым: 5 | Беттер: 53-63
DEVELOPMENT OF HALOPLEX PANEL AND PREPARATION OF DNA LIBRARIES FOR TARGETED SEQUENCING OF CARDIAC ARRHYTHMIAS
Method of preparation of custom HaloPlex cardiogenetic panel (Agilent Technologies) and method of preparation of DNA libraries for targeted sequencing of 96 genes associated with cardiac arrhythmias were described in details in this article. SureDesign Online Design software (Agilent Technologies) was used to create the HaloPlex panel. Final design was developed for Illumina platform using Human Genome version 19, GRCh 37. 19958 amplicons were generated by the program, 99,46% of all target regions were covered successfully. DNA libraries were prepared for 48 samples using t...
Толығырақ
2016 жыл | Шығарылым: 5 | Беттер: 43-52
DETERMINATION OF GENETIC VARIANTS ASSOCIATED WITH HYPERTENSION, OBESITY AND DIABETES IN KAZAKH POPULATION TO STUDY INTERACTION OF GENETIC VARIANTS AND METABOLOME
In this work genetic variants associated with hypertension, obesity and diabetes were characterized, and genomic data of 60 samples were compared using Т-HOD (The Text-mined Hypertension, Obesity and Diabetes candidate gene database (T-HOD) international database.
Genetic variants extracted from whole genomes and exomes, and associated with hypertension, obesity and diabetes based on PolyPhen2 and SIFT algorithmic predictors of mutation pathogenicity were analyzed. Seven genetic variants were detected in GHRL (rs4684677), MTHFR (rs1801133), OPRM1 (rs17999... Толығырақ
Genetic variants extracted from whole genomes and exomes, and associated with hypertension, obesity and diabetes based on PolyPhen2 and SIFT algorithmic predictors of mutation pathogenicity were analyzed. Seven genetic variants were detected in GHRL (rs4684677), MTHFR (rs1801133), OPRM1 (rs17999... Толығырақ
2016 жыл | Шығарылым: 5 | Беттер: 30-42