Online ISSN: 3007-0244,
Print ISSN:  2410-4280
DETECTION OF MUTATIONS IN RPOB GENE RESPONSIBLE FOR RIFAMPICIN-RESISTANCE AMONG CLINICAL ISOLATES OF M. TUBERCULOSIS FROM DIFFERENT REGIONS OF KAZAKHSTAN
Spectrum of mutations in rpoB gene that cause resistance to one of the main antituberculosis drugs – rifampicin in clinical isolates of M. tuberculosis distributed in 3 regions (Almaty, Kostanay, Kyzylorda) of Kazakhstan was estimated in this study. High frequency of mutation at codon Ser531 of rpoB gene (79,2%) responsible for drug resistance to rifampicin was determined among M. tuberculosis population circulating in the mentioned regions.
А.Zh. Аkhmetova1, S.Е. Rakhimova1, V.L. Bismilda2, М.А. Darisheva3, A.R. Akilzhanova1 1Center for Life Sciences, Nazarbayev University, Astana 2 National Center for Tuberculosis Problems, Almaty 3 Global Health Research Center of Central Asia, Almaty
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А.Ж. Ахметова1, С.Е. Рахимова1, В.Л. Бисмилда2, М.А. Даришева3, А.Р. Акилжанова1 ОПРЕДЕЛЕНИЕ МУТАЦИЙ В RPOB ГЕНЕ, ОБУСЛАВЛИВАЮЩИХ УСТОЙЧИВОСТЬ К РИФАМПИЦИНУ СРЕДИ КЛИНИЧЕСКИХ ИЗОЛЯТОВ M. TUBERCULOSIS ИЗ РАЗЛИЧНЫХ ОБЛАСТЕЙ КАЗАХСТАНА //Наука и Здравоохранение 2014.№ 4. С. 26-27 А.Zh. Аkhmetova1, S.Е. Rakhimova1, V.L. Bismilda2, М.А. Darisheva3, A.R. Akilzhanova1 DETECTION OF MUTATIONS IN RPOB GENE RESPONSIBLE FOR RIFAMPICIN-RESISTANCE AMONG CLINICAL ISOLATES OF M. TUBERCULOSIS FROM DIFFERENT REGIONS OF KAZAKHSTAN // Nauka i Zdravookhranenie. 2014.№ 4. С. 26-27 А.Ж. Ахметова1, С.Е. Рахимова1, В.Л. Бісмілда2, М.А. Даришева3, А.Р. Ақылжанова1 ҚАЗАҚСТАННЫҢ ӘР ТҮРЛІ ОБЛЫСТАРЫНДА ТАРАЛҒАН M. TUBERCULOSIS ИЗОЛЯТТАРЫНЫҢ РИФАМПИЦИНГЕ ТӨЗІМДІЛІГІН АНЫҚТАЙТЫН RPOB ГЕНІНДЕ МУТАЦИЯЛАРДЫ АНЫҚТАУ // Ғылым және Денсаулық сақтау 2014.№ 4. С. 26-27

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