Online ISSN: 3007-0244,
Print ISSN:  2410-4280
ЖЕДЕЛ ЖҮРЕК ИНФАРКТІСІ БАР НАУҚАСТАРДА ЖЕДЕЛ ЖҮРЕК ӨЛІМІНІҢ ЕКІНШІ ПРОФИЛАКТИКАСЫ РЕТІНДЕ ОМЕГА-3 МАЙ ҚЫШҚЫЛДАРЫН ПАЙДАЛАНУ: ЖҮЙЕЛІК ШОЛУ ЖӘНЕ МЕТА АНАЛИЗ
Кіріспе. Миокард инфарктісінің жиілігі әсіресе жас және орта жастағы адамдар арасында өсуде - 40 жасқа толмағандар саны 35%-ға жетеді. Зардап шеккендер қайталанатын тамырлы апаттың жоғары тәуекеліне ие: ерлердің 18%-ы және 35%-ы келесі 6 жыл ішінде екінші миокард инфарктісінен зардап шегеді. Жүрек-қан тамырлары ауруларынан болатын өлім-жітімді айтарлықтай төмендетуге қол жеткізген елдердің, соның ішінде Құрама Штаттардың тәжірибесі жүрек-қан тамырларының қауіп факторлары тұжырымдамасына негізделген миокард инфарктысының алдын алу бойынша белсенді жұмыс жасау қажеттігін көрсетеді. Осы стратегияны іске асыру пациенттердің өмір салтын өзгерту және диетотерапия бағытында өзгеруімен қауіпті факторларды белсенді түрде түзетуді талап етеді, бұл тұтынылған теңіз өнімдерінің мөлшерін ұлғайта отырып, қызыл етті тұтынуды азайтуға бағытталған, ол омега-3 май қышқылдарының табиғи көздері болып табылады. Мақсаты: Рандомизацияланған бақылаулы сынақтардың жүйелі түрде қайта қарауы және кездейсоқ әсерлер модельдерін қолданып, жүрек инфарктынан кейін пациенттерде омега-3 май қышқылдарының қабылдауының КЖӨ алдын алуға зерттеуге арналған. Зерттеу әдістері. Іріктеу критерийлері бойынша Web of Science, PUBMED және e-library дерекқорларынан іріктелген зерттеулерден алынған мәліметтерді сапалы түрде синтездеу мета-анализ түрінде сандық синтезмен толықтырылды, кездейсоқ эффектілердің үлгілері пайдаланылды, бұл ең сенімді және жекелеген зерттеу нәтижелерінің әртүрлілігін мойындайтын жүйелік шолу мен мета-анализ. Нәтижелері. Салмақталған RR 0,83 (95% CI: 0,59; 1,18) болды. Жекелеген зерттеулердің нәтижелері бойынша маңызды гетерогенділік анықталды (Q тесті = 19,50; df = 4, p <0,001). Жеке зерттеулердің RR ауыспалығы 80% (95% CI: 51; 91) индикаторы бойынша осы біртектіліктен туындады. R үшін 95% болжалды интервал 0,26-2,61 болды. Қорытынды: Жүйелі шолу мен мета-талдау негізінде, омега-3 МҚ көздерінен жедел миокард инфарктісі болған науқастарда кенеттен жүрек өлімінің алдын-алу туралы ешқандай дәлел жоқ. Болашақта алынған нәтижелерді растау немесе жоққа шығару үшін үлкен проспективті зерттеулер жүргізу қажет.
Раушан Ш. Тулеуова 1, https://orcid.org/0000-0002-0964-3841 Андрей М. Гржибовский 1-4, http://orcid.org/0000-0002-5464-0498 Лаззат М. Жамалиева 1, http://orcid.org/0000-0003-3625-3651 Дамира Г. Жаманкулова 1, https://orcid.org/0000-0001-6943-0664 1 Батыс Қазақстан Марат Оспанов атындағы Мемлекеттік медицина университеті, Ақтөбе қ., Қазақстан Республикасы; 2 М.К. Аммосов атындағы Солтүстік-Шығыс Федералдық Университеті, Якутск қ., Ресей; 3 Әл-Фараби атындағы Қазақ ұлттық университеті, Алматы қ., Қазақстан Республикасы. 4 Солтүстік Мемлекеттік Медициналық университеті, Архангельск қ., Ресей
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