БАЛАЛАРДАҒЫ МЕДУЛЛОБЛАСТОМАНЫҢ ГЕНЕТИКАЛЫҚ НҰСҚАЛАРЫ ЖӘНЕ ОНЫ ЕМДЕУ ТӘСІЛДЕРІ. ӘДЕБИЕТТІК ШОЛУ
Өзектілігі: Медуллобластома – балалық шақтағы орталық жүйке жүйесінің ең жиі кездесетін қатерлі ісіктерінің бірі. Аурудың генетикалық сипаттамалары емдеу тәсілдерін анықтауда маңызды рөл атқаруы мүмкін, бірақ бұл аспект бүгінгі күнге дейін жеткілікті түрде зерттелмеген.
Мақсаты: емдеу траекториясын мақсатты түрде қалыптастыру мүмкіндігі контекстінде медуллобластоманың генетикалық нұсқалары туралы қазіргі ақпараттың жалпы сипаттамасы.
Іздеу стратегиясы: 2012-2022 жылдарға арналған ғылыми-зерттеу саласындағы бірқатар түпнұсқа жарияланымдар мен шолулар талданды, бірақ біз сондай-ақ 2012 жылдың бұрын жарияланымдарды енгіздік, өйткені олар балалық шақтағы осы патологияға қатысты ақпаратты және ауруды емдеу мен стратификациялаудың классикалық негізгі тәсілдерін қамтиды. Жарияланымдарды іріктеу шолу мақсатына сәйкес жүргізілді - заманауи емдеуге сәйкес медуллобластоманың генетикасының ең толық және жинақы сипаттамасы.
Нәтижелер мен қорытындылар: Жалпы, қазіргі уақытта сәулелік және химиотерапияның әртүрлі жанама әсерлеріне негізделген балалардағы МБ - ны емдеудің сараланған тәсілдерін әзірлеу үшін айтарлықтай негіздер бар. Алайда, тіпті әлемдік медицинада да мұндай тәсілдерді практикалық қолдану шектеулі. Қазіргі уақытта көптеген кіші типтері бар медуллобластоманың 4 негізгі генетикалық түрі бар, осыған байланысты терапияның деэскалациясы туралы кейбір гипотезалар ұсынылды. Генетикалық типтердің емдеуге әсері туралы деректер бірлік зерттеулермен шектеледі және ұсынылған гипотезаларға сәйкес түпкілікті бекітілген қорытындылар ұсынымдық материалдарда көрсетілмеген.
Райгуль Р. Нусупова1, https://orcid.org/0000-0002-8039-4446
Лаура А. Пак2, https://orcid.org/0000-0002-5249-3359
Мейрам С. Мулдахметов1, https://orcid.org/0000-0002-8389-2061
Бакыткали А. Ибраимов3
1 «Астана медицина университетi» КЕАҚ, Нұр-Сұлтан қ., Қазақстан Республикасы;
2 «Семей медицина университетi», КЕАҚ, Семей қ., Қазақстан Республикасы;
3 «University Medical Center» Корпоративтік қорi, Нұр-Сұлтан қ., Қазақстан Республикасы.
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Нусупова Р.Р., Пак Л.А., Мулдахметов М.С., Ибраимов Б.А. Балалардағы медуллобластоманың генетикалық нұсқалары және оны емдеу тәсілдері. Әдебиеттік шолу // Ғылым және Денсаулық сақтау. 2022. 5 (Т.24). Б. 166-178. doi 10.34689/SH.2022.24.5.021Ұқсас жариялымдар:
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