ФОРМИРОВАНИЕ ОЧАГОВ Р53 СВЯЗАННОГО БЕЛКА 1 В ОПУХОЛЯХ ЩИТОВИДНОЙ ЖЕЛЕЗЫ: АКТИВАЦИЯ ГЕНЕТИЧЕСКОЙ НЕСТАБИЛЬНОСТИ В ТЕЧЕНИИ КАНЦЕРОГЕНЕЗА ЩИТОВИДНОЙ ЖЕЛЕЗЫ. ОБЗОР ЛИТЕРАТУРЫ
Введение: К настоящему времени достигнуты большие успехи в изучении молекулярно–клеточных механизмов канцерогенеза, установлении роли онкогенов и антионкогенов в развитии опухолей различной локализации, в том числе и РЩЖ. Подавляющее число доброкачественных и злокачественных опухолей щитовидной железы развивается из фолликулярного эпителия, которые имеют разную степень дифференцировки, разные морфогенетические и биохимические особенности, клиническое течение и прогноз.
Цель: проведение поиска научной информации по активации генетической нестабильности в течений канцерогенеза щитовидной ... Толығырақ
Цель: проведение поиска научной информации по активации генетической нестабильности в течений канцерогенеза щитовидной ... Толығырақ
2019 жыл | Шығарылым: 2 | Беттер: 25-37
ОРГАНИЗАЦИОННЫЕ ОСНОВЫ СКРИНИНГА КОЛОРЕКТАЛЬНОГО РАКА В МИРОВОЙ МЕДИЦИНСКОЙ ПРАКТИКЕ. ОБЗОР ЛИТЕРАТУРЫ
Актуальность. Рак ободочной и прямой кишки (колоректальный) является третьим по распространенности раком в мире. Он поддается скринингу, так как скрининговое исследование может быть осуществлено на предраковых, латентных, ранних и излечимых стадиях. При скрининге колоректального рака могут использоваться прямые или непрямые методы, применяемые произвольно или в структуре организованных программ. Большинство случаев колоректального рака диагностируется в возрасте старше 60 лет. Большинство программ скрининга относятся к лицам в возрасте 50-75 лет.
Цель обзора – Анализ подходов и р... Толығырақ
Цель обзора – Анализ подходов и р... Толығырақ
2019 жыл | Шығарылым: 2 | Беттер: 13-24
MODERN TENDENCY IN TREATMENT OF PATIENTS WITH SEVERE TRAUMATIC BRAIN INJURY. LITERARY REVIEW
Relevance: Carrying out of intensive therapy at severe traumatic brain injury is a complex of measures aimed on saving of the brain tissues and maintaining its functions. To achieve this goal, it is necessary to do timely diagnostics and monitoring of critical parameters - intracranial pressure and cerebral perfusion pressure; pathogenetically based therapy and nutritional support for critically ill patients.
Aim: The goal of this review was to find evidences of admissibility of use for such methods as control of cerebral perfusion pressure and intracranial pressure, anti-edematous thera... Толығырақ
Aim: The goal of this review was to find evidences of admissibility of use for such methods as control of cerebral perfusion pressure and intracranial pressure, anti-edematous thera... Толығырақ
2019 жыл | Шығарылым: 2 | Беттер: 5-12
ЛЕЧЕНИЕ ПОПЕРЕЧНОГО ПЛОСКОСТОПИЯ С HALLUX VALGUS ПРИ I и II ТИПЕ РАСПЛАСТАННОСТИ СТОПЫ
Введение. Статическая деформация переднего отдела стопы составляет до 80% среди ортопедической патологии стопы у взрослых. Патология вызывает значительное нарушение биомеханики всей нижней конечности, сопровождаясь болью в переднем отделе стопы, затруднение в подборе и ношении обуви, значительно снижает трудоспособность и качество жизни пациента. В связи с этим разработка технологии лечения статической деформации переднего отдела стопы, предусматривающей устранение Halluxvalgus, metatarsusprimavarus и плантарную девиацию центральных лучей стопы остается не полностью решенной и актуальной п...
Толығырақ
2019 жыл | Шығарылым: 1 | Беттер: 80-90
АНТИБИОТИКОРЕЗИСТЕНТНОСТЬ ШИГЕЛЛ НА СОВРЕМЕННОМ ЭТАПЕ
Введение. Одна из больших проблем практического здравоохранения на современном этапе – это рост антибиотикорезистентности шигелл к тем антибактериальным препаратам, которые широко сегодня используются в их лечении.
Цель исследования: изучить чувствительность штаммов Shigella spp., выделенных из кишечника больных острой дизентерией, к широко используемым в клинической практике антимикробным препаратам.
Материалы и методы. Проведен ретроспективный анализ 236 медицинских карт пациентов с диагнозом острой дизентерии, пролеченных на базе Городской инфекционной больница г. Астана за пе... Толығырақ
Цель исследования: изучить чувствительность штаммов Shigella spp., выделенных из кишечника больных острой дизентерией, к широко используемым в клинической практике антимикробным препаратам.
Материалы и методы. Проведен ретроспективный анализ 236 медицинских карт пациентов с диагнозом острой дизентерии, пролеченных на базе Городской инфекционной больница г. Астана за пе... Толығырақ
2019 жыл | Шығарылым: 1 | Беттер: 74-79
PRELIMINARY ANALYSIS OF THE HEALTH STATUS AND RADIATION DOSES OF RESIDENTS OF THE ABAY DISTRICT OF THE ABAY REGION, WHO ARE DESCENDANTS OF PERSONS EXPOSED TO RADIATION DUE TO NUCLEAR WEAPONS TESTS
2025 жыл | Шығарылым: 5 | Беттер: 32-39
TRENDS AND DISPARITIES IN CANCER MORBIDITY IN KAZAKHSTAN: A REGIONAL AND AGE-BASED ANALYSIS FOR 2014-2024
2025 жыл | Шығарылым: 5 | Беттер: 40-46
PATIENTS’ PERCEPTIONS OF THE QUALITY AND ACCESSIBILITY OF REHABILITATION SERVICES FOR LUNG CANCER: A CROSS-SECTIONAL STUDY
2025 жыл | Шығарылым: 5 | Беттер: 47-55
COMPARATIVE ANALYSIS OF COMPUTER TOMOGRAPHIC STAGING AND POSTOPERATIVE PATHOMORPHOLOGICAL STAGING IN STOMACH CANCER
2025 жыл | Шығарылым: 5 | Беттер: 56-62
REDUCTION OF RESIDUAL MONOMER IN THE FIXED PROSTHESIS MADE OF ACRYLIC PLASTICS AND ITS ASSOCIATION WITH IMMUNO-METABOLIC PROFILE OF PATIENTS
Today, in the treatment of fixed prosthetic constructions is extremely important the use of temporary crowns in order to adapt the impression area, restoration of chewing function and increasing of quality of life of patients already on treatment stages. In this aspect significant is the level of residual monomer content, as it is known from experimental and clinical studies, methyl methacrylate is histotoxic substances.
The aim of this work was the research in conditions of clinics determination of efficiency of manufacturing plastic crowns, while ensuring the reduction of the residual ... Толығырақ
The aim of this work was the research in conditions of clinics determination of efficiency of manufacturing plastic crowns, while ensuring the reduction of the residual ... Толығырақ
2016 жыл | Шығарылым: 1 | Беттер: 77-88
CLINICAL AND MORPHOLOGICAL FEATURES OF BREAST CANCER AMONG WOMEN WITH RADIOECOLOGICAL AND FAMILY ANAMNESIS
The peculiarities of histomorphological characteristics of malignant neoplasm can be linked to its genesis, including the presence of genetic changes in regulatory genes. By-turn, the frequency of the last depends from the influence of mutagenic factors.
The aim. The purpose of research is to determine the morphological features of breast cancer due to the presence of gene mutations BRCА1 and TP53 among women with family and radioecological anamnesis.
Materials and methods. The study included 190 women aged between 40 to 78 years, patients with breast cancer, ethnic Kazakhs, alloc... Толығырақ
The aim. The purpose of research is to determine the morphological features of breast cancer due to the presence of gene mutations BRCА1 and TP53 among women with family and radioecological anamnesis.
Materials and methods. The study included 190 women aged between 40 to 78 years, patients with breast cancer, ethnic Kazakhs, alloc... Толығырақ
2016 жыл | Шығарылым: 1 | Беттер: 66-76
MINERALIZATION OF THE PERITONEUM IN PERITONEAL CARCINOMATOSIS
Conducted assessment of sero-lymphatic hatches and submesothelial relief structures of the parietal peritoneum in peritoneal carcinomatosis. The object of study of autopsy material from deceased neglected forms of malignant neoplasms 2012-2015. We believe that the data obtained will make a significant contribution to the theory of cancer metastasis.
The purpose of the study. To assess the serous-lymphatic hatches (SLH) diaphragmatic and pelvic peritoneum cancer with the phenomenon of PC and to examine their role in the pathogenesis of dissemination of cancer cells on the peritone... Толығырақ
The purpose of the study. To assess the serous-lymphatic hatches (SLH) diaphragmatic and pelvic peritoneum cancer with the phenomenon of PC and to examine their role in the pathogenesis of dissemination of cancer cells on the peritone... Толығырақ
2016 жыл | Шығарылым: 1 | Беттер: 54-65
COMPARATIVE EVALUATION OF CHOLECYSTECTOMY TECHNIQUES
Introduction: The review compares the efficacy and safety of mini-laporatomy, laparoscopy and traditional cholecystectomy. We summarizes results of studies on advantages and disadvantages of various methods of cholecystectomy with considering of after-operational complications, mortality, average residence of patients in hospital and rehabilitation period.
The aim: to summarize and compare modern cholecystectomy techniques.
Materials and methods: Systematic review and subsequent analysis of publication data and online sources were carried outusing PubMed, MEDLINE, books, publicati... Толығырақ
The aim: to summarize and compare modern cholecystectomy techniques.
Materials and methods: Systematic review and subsequent analysis of publication data and online sources were carried outusing PubMed, MEDLINE, books, publicati... Толығырақ
2016 жыл | Шығарылым: 1 | Беттер: 40-53
АTHEROGENESIS AND INFLAMMATION
Introduction: The article presents atherosclerosis theory and modern views on the role of inflammation in atherogenesis. We reviewed national and international literature on inflammatory theory of atherosclerosis, the role of cytokines in the development of atherosclerosis, the interaction of the lipid and inflammatory theory of atherogenesis, the formation of atherosclerotic plaque. Basic research in molecular biology, immunology, genetics have greatly expanded the concept of the pathogenesis of atherosclerosis.
The aim: Сonducting a literature review on the pathogenesis of atheroscler... Толығырақ
The aim: Сonducting a literature review on the pathogenesis of atheroscler... Толығырақ
2016 жыл | Шығарылым: 1 | Беттер: 24-39