Online ISSN: 3007-0244,
Print ISSN:  2410-4280
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ОРГАНИЗАЦИОННЫЕ ОСНОВЫ СКРИНИНГА КОЛОРЕКТАЛЬНОГО РАКА В МИРОВОЙ МЕДИЦИНСКОЙ ПРАКТИКЕ. ОБЗОР ЛИТЕРАТУРЫ
Автор (лар): Жолмурзаева Р.С
Актуальность. Рак ободочной и прямой кишки (колоректальный) является третьим по распространенности раком в мире. Он поддается скринингу, так как скрининговое исследование может быть осуществлено на предраковых, латентных, ранних и излечимых стадиях. При скрининге колоректального рака могут использоваться прямые или непрямые методы, применяемые произвольно или в структуре организованных программ. Большинство случаев колоректального рака диагностируется в возрасте старше 60 лет. Большинство программ скрининга относятся к лицам в возрасте 50-75 лет.
Цель обзора – Анализ подходов и р...
Толығырақ
2019 жыл | Шығарылым: 2 | Беттер: 13-24

MODERN TENDENCY IN TREATMENT OF PATIENTS WITH SEVERE TRAUMATIC BRAIN INJURY. LITERARY REVIEW
Relevance: Carrying out of intensive therapy at severe traumatic brain injury is a complex of measures aimed on saving of the brain tissues and maintaining its functions. To achieve this goal, it is necessary to do timely diagnostics and monitoring of critical parameters - intracranial pressure and cerebral perfusion pressure; pathogenetically based therapy and nutritional support for critically ill patients.
Aim: The goal of this review was to find evidences of admissibility of use for such methods as control of cerebral perfusion pressure and intracranial pressure, anti-edematous thera...
Толығырақ
2019 жыл | Шығарылым: 2 | Беттер: 5-12

ЛЕЧЕНИЕ ПОПЕРЕЧНОГО ПЛОСКОСТОПИЯ С HALLUX VALGUS ПРИ I и II ТИПЕ РАСПЛАСТАННОСТИ СТОПЫ
Введение. Статическая деформация переднего отдела стопы составляет до 80% среди ортопедической патологии стопы у взрослых. Патология вызывает значительное нарушение биомеханики всей нижней конечности, сопровождаясь болью в переднем отделе стопы, затруднение в подборе и ношении обуви, значительно снижает трудоспособность и качество жизни пациента. В связи с этим разработка технологии лечения статической деформации переднего отдела стопы, предусматривающей устранение Halluxvalgus, metatarsusprimavarus и плантарную девиацию центральных лучей стопы остается не полностью решенной и актуальной п...
Толығырақ
2019 жыл | Шығарылым: 1 | Беттер: 80-90

АНТИБИОТИКОРЕЗИСТЕНТНОСТЬ ШИГЕЛЛ НА СОВРЕМЕННОМ ЭТАПЕ
Введение. Одна из больших проблем практического здравоохранения на современном этапе – это рост антибиотикорезистентности шигелл к тем антибактериальным препаратам, которые широко сегодня используются в их лечении.
Цель исследования: изучить чувствительность штаммов Shigella spp., выделенных из кишечника больных острой дизентерией, к широко используемым в клинической практике антимикробным препаратам.
Материалы и методы. Проведен ретроспективный анализ 236 медицинских карт пациентов с диагнозом острой дизентерии, пролеченных на базе Городской инфекционной больница г. Астана за пе...
Толығырақ
2019 жыл | Шығарылым: 1 | Беттер: 74-79

RADIATION-INDUCED KI-67 PROLIFERATION IN THE SMALL INTESTINE OF RATS
Introduction. It is known that Hiroshima and Nagasaki were target of the first atomic bombs in the history of mankind. As a result, the population of Japanese cities was exposed to internal and external irradiation. Numerous authors maintain that primary neutron-activated radionuclides are chemical elements 56Mn and 60Co. Herewith, 56Mn was determined the dominant role of neutrons induced by β-radiation during the first few hours after the atomic bombing. The systemic access in estimation of Кi-67 marker in radiosensitive small intestine defining the functional state and the interrelation of s...
Толығырақ
2019 жыл | Шығарылым: 1 | Беттер: 63-73

DANGEROUS AND UNDESIRABLE DRUG INTERACTIONS OF STATINS IN PATIENTS WITH CARDIOVASCULAR DISEASE
Relevance. Antihypercholesterolemic drugs fr om the group of statins have a significant impact on the metabolism of the human body. Consideration of pharmacokinetic features of statins and drug interaction with drugs of this group is an important aspect of their safe use. Drugs administered simultaneously with statins may be inducers or inhibitors (substrates) of CYP3A4/A5 cytochrome P450 liver isoenzymes, which should be considered in daily clinical practice in the management of this category of patients
The aim was to study the frequency and structure of the appointment of unw...
Толығырақ
2019 жыл | Шығарылым: 2 | Беттер: 55-66

PREVALENCE OF ATRIAL FIBRILLATION AND ITS CORRELATES IN HYPERTENSIVE PATIENTS WITHOUT CORONARY HEART DISEASE IN PRIMARY CARE SETTING
Hypertension is a risk factor for atrial fibrillation (AF). Primary prevention of AF in hypertension patients is the ultimate goal of the medical and public health community.
Aim: assess the prevalence and factors associated with AF in hypertensive patients without coronary heart disease (CHD) in primary care setting.
Methods: A cross–sectional study was conducted in January-September 2018. Hypertensive patients 40 years and above visiting primary care clinics during the study period were recruited (n=1121). Exclusion criteria were rheumatic and congenital h...
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2019 жыл | Шығарылым: 2 | Беттер: 44-54

RHEUMATOID ARTHRITIS AND FERTILITY: LITERATURE REVIEW
Introduction. Rheumatoid arthritis is a chronic inflammatory autoimmune disease that leads to disability, which occurs in women of predominantly childbearing age three times more often than men. Unfortunately, the issue of childbirth can be associated not only with the activity of the disease, but also with the availability of comprehensive medical care and knowledge of pharmacological treatment methods. Therefore, many women are struggling to find adequate information about planning pregnancy, childbirth and lactation.
Availability and advanced choice of pharmacotherapy can maintain the...
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2019 жыл | Шығарылым: 2 | Беттер: 38-43

FORMATION OF FOCI OF P53 BOUND PROTEIN 1 IN THYROID TUMORS: ACTIVATION OF GENETIC INSTABILITY DURING THYROID CARCINOGENESIS. LITERATURE REVIEW
Introduction: In our days big successes have been reached in studying of molecular–cellular mechanisms in carcinogenesis, establishing the role of oncogens and antioncogens in the development of tumors with various localization, including thyroid cancer. The vast majority of benign and malignant tumors of the thyroid gland develops from the follicular epithelium, which have different degrees of differentiation, different morphogenetic and biochemical features, clinical course and prognosis.
Objective: to conduct a search for scientific information on the activation of genetic instability...
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2019 жыл | Шығарылым: 2 | Беттер: 25-37

ORGANIZATIONAL BASICS OF SCREENING FOR COLORECTAL CANCER IN WORLD MEDICAL PRACTICE. LITERATURE REVIEW
Автор (лар): Жолмурзаева Р.С
Actuality Colorectal cancer (CRC) tacked the third place in worldwide common cancer. The revealing of CRC on premalignant, latent and curable stages is important method of decrease of mortality. CRC screening can use direct or indirect tests, delivered opportunistically or via organized programs. Most CRCs are diagnosed after 60 years of age; most screening programs apply to individuals 50-75 years of age.
The purpose of the review is to analyze the approaches and results of screening of colorectal cancer in the world medical practice in order to formulate recommendations for dom...
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2019 жыл | Шығарылым: 2 | Беттер: 13-24