ЭПИЛЕПСИЯ ПРИ ОСТРОЙ И ХРОНИЧЕСКОЙ ЦЕРЕБРАЛЬНОЙ ИШЕМИИ
Введение. Эпилепсия является одним из наиболее распространенных заболеваний нервной системы. Одним из наиболее частых факторов риска развития эпилептических припадков является ишемия головного мозга.
Цель исследования: изучить клинические, нейровизуализиционные, функциональные и гемодинамические особенности у больных с эпилептическими припадками на фоне острой и хронической ишемии головного мозга.
Материалы и методы: исследование проспективное когортное контролируемое. Комплексно обследовано 772 пациента с ишемией головного мозга с развитием эпилептических припадков: основную груп... Толығырақ
Цель исследования: изучить клинические, нейровизуализиционные, функциональные и гемодинамические особенности у больных с эпилептическими припадками на фоне острой и хронической ишемии головного мозга.
Материалы и методы: исследование проспективное когортное контролируемое. Комплексно обследовано 772 пациента с ишемией головного мозга с развитием эпилептических припадков: основную груп... Толығырақ
2016 жыл | Шығарылым: 2 | Беттер: 70-83
ПРОФИЛАКТИКА ИШЕМИЧЕСКИХ ОСЛОЖНЕНИЙ СО СТОРОНЫ СЕРДЦА И ГОЛОВНОГО МОЗГА ПРИ ОТКРЫТОМ ПРОТЕЗИРОВАНИИ ИНФРАРЕНАЛЬНОЙ АНЕВРИЗМЫ БРЮШНОЙ АОРТЫ
Введение. Проблема определения тактики хирургического лечения аневризмы брюшной аорты (АБА) на фоне сочетанного поражения сонных и коронарных артерий является актуальной и многогранной, и пока не нашла своего окончательного решения.
Цель исследования. Изучить эффективность терапевтической и поэтапной хирургической коррекции сочетанной патологии коронарных и сонных артерий при открытом протезировании АБА.
Методы. Расчет размера выборки выполняли для регрессионного анализа при помощи программы PASS 2000, версия 12.0.4. Проведено ретроспективное и проспективное нерандомизиров... Толығырақ
Цель исследования. Изучить эффективность терапевтической и поэтапной хирургической коррекции сочетанной патологии коронарных и сонных артерий при открытом протезировании АБА.
Методы. Расчет размера выборки выполняли для регрессионного анализа при помощи программы PASS 2000, версия 12.0.4. Проведено ретроспективное и проспективное нерандомизиров... Толығырақ
2016 жыл | Шығарылым: 2 | Беттер: 56-69
РЕКОМЕНДАТЕЛЬНЫЕ МЕРЫ ПО ПРЕДОТВРАЩЕНИЮ САМОУБИЙСТВ В ЮЖНОЙ КОРЕЕ И ЯПОНИИ НА ОСНОВЕ ПОСЛЕДНИХ РЕЗУЛЬТАТОВ ИССЛЕДОВАНИЙ СУИЦИДА: ДАННЫЙ ПОДХОД НЕОБХОДИМО ИСПОЛЬЗОВАТЬ ПРИ РАЗРАБОТКЕ БУДУЩИХ МЕР ПО ПРЕДОТВРАЩЕНИЮ САМОУБИЙСТВ НА ОСТАЛЬНОЙ ТЕРРИТОРИИ АЗ...
Introduction: Devising and implementing effective suicide prevention measures is an urgent matter for countries around the world. South Korea and Japan have some of the world’s highest suicide rates, so the current study examined more effective suicide prevention measures for those countries with a focus on recent suicide rates by age group.
Materials and Methods: This study examined the suicide rate for each sex by age group in South Korea and Japan in 2009 and 2012, and this study then calculated the ratio of South Korea's suicide rate to Japan's suicide rate. Based on the suic... Толығырақ
Materials and Methods: This study examined the suicide rate for each sex by age group in South Korea and Japan in 2009 and 2012, and this study then calculated the ratio of South Korea's suicide rate to Japan's suicide rate. Based on the suic... Толығырақ
2016 жыл | Шығарылым: 2 | Беттер: 47-55
ИНДИКАТОРЫ ОЦЕНКИ РАЦИОНАЛЬНОСТИ ЛЕКАРСТВЕННОЙ ТЕРАПИИ
Фармакотерапия на сегодняшний день является основным видом лечения большинства заболеваний. Она оказывает влияние на исход, выживаемость, и качество жизни пациентов. Фармакотерапия должна быть направлена на проведение эффективного, грамотного, безопасного, рационального, индивидуализированного и экономного лечения. Лекарственные препараты играют важную роль в современном мире. Расходы государства на них являются самой быстро растущей статьей бюджетов здравоохранения, достигая в некоторых странах до 40%. На фоне недостатка финансовых ресурсов, квалифицированной медицинской помощи, во многих...
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2016 жыл | Шығарылым: 2 | Беттер: 29-46
СРАВНЕНИЕ КОЛИЧЕСТВЕННЫХ ДАННЫХ ДВУХ НЕЗАВИСИМЫХ ВЫБОРОК С ИСПОЛЬЗОВАНИЕМ ПРОГРАММНОГО ОБЕСПЕЧЕНИЯ STATISTICA И SPSS: ПАРАМЕТРИЧЕСКИЕ И НЕПАРАМЕТРИЧЕСКИЕ КРИТЕРИИ
В настоящей работе представлены общие сведения об использовании параметрического непарного критерия Стьюдента и непараметрического критерия Манна-Уитни для сравнения количественных признаков в независимых выборках. Описан алгоритм расчета критериев с использованием программного обеспечения Statistica 10 и SPSS 20, а также представлена интерпретация результатов расчетов. Настоящая статья призвана дать общие сведения об использовании критериев Стьюдента и Манна-Уитни, и не заменяет прочтения специализированной литературы по статистике и клинической эпидемиологии.
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2016 жыл | Шығарылым: 2 | Беттер: 5-28
COMPARATIVE EVALUATION OF BLOOD COLLECTION TUBES AND EXTRACTION METHODS FOR CIRCULATING TUMOR DNA
2025 жыл | Шығарылым: 6 | Беттер: 7-13
INFLUENCE OF SEX HORMONE-BINDING GLOBULIN (SHBG) ON THE LEVEL OF FREE TESTOSTERONE FRACTION IN OLDER OVERWEIGHT MEN
2025 жыл | Шығарылым: 6 | Беттер: 14-20
ASSESSMENT OF THE PROBABILITY OF DEVELOPING CARDIORENAL SYNDROME TYPE 2 DEPENDING ON POTENTIAL BIOMARKERS IN PEDIATRIC PATIENTS
2025 жыл | Шығарылым: 6 | Беттер: 21-29
MORPHO-GENETIC VARIABILITY IN MYOCARDIAL TISSUE AFTER SEPTAL MYECTOMY IN PATIENTS WITH OBSTRUCTIVE HYPERTROPHIC CARDIOMYOPATHY: A FOUR-CASE SERIES STUDY
2025 жыл | Шығарылым: 6 | Беттер: 30-37
CLINICAL EFFICACY OF SELECTIVE PLASMA FILTRATION (EVACLIO) IN CARDIOVASCULAR COMPLICATIONS: A CASE SERIES FROM THE HEART CENTER KAZAKHSTAN
2025 жыл | Шығарылым: 6 | Беттер: 38-46
CAUSES OF REFUSING MEDICAL EXAMINATIONBY PATIENTS WITH SUSPECTED CANCER AS PERCEIVED BY PRIMARY CARE PHYSICIANS IN SOUTH KAZAKHSTAN REGION
Objective: To identify the most frequent causes of refusing thorough medical examinations by patients with suspected cancer as perceived by primary care physicians in South Kazakhstan Region (SKR).
Methods: We performed a cross-sectional study, which included 500 primary care physicians in SKR. Data collection took place between 01 January 2016 and 14 April 2016). The questionnaire contained 33 semi-open questions. Filling out time was between 20 and 25 minutes. Only doctors who worked at policlinics during the time of the study were included. Results are presented absolute n... Толығырақ
Methods: We performed a cross-sectional study, which included 500 primary care physicians in SKR. Data collection took place between 01 January 2016 and 14 April 2016). The questionnaire contained 33 semi-open questions. Filling out time was between 20 and 25 minutes. Only doctors who worked at policlinics during the time of the study were included. Results are presented absolute n... Толығырақ
2016 жыл | Шығарылым: 5 | Беттер: 90-100
IMPACT OF ERYTHROCYTES ANTIGENS ON DEVELOPMENT OF LIVER CIRRHOSIS
Introduction. High rates of prevalence and mortality of liver cirrhosis, it’s late clinical manifestation, disadvantages of liver biopsy highlight the background points of our research.
Aim. Research of erythrocytes’ antigens profile in patients with liver cirrhosis of Kazakh and Russian ethnical groups.
Materials and Methods: One hundred and forty patients with liver cirrhosis and 272 relatively healthy participants of both of nationalities were involved into research. АВ0, MNS, P1, CDE systems of erythrocytes of venous blood were investigated. For the comparison of the frequenc... Толығырақ
Aim. Research of erythrocytes’ antigens profile in patients with liver cirrhosis of Kazakh and Russian ethnical groups.
Materials and Methods: One hundred and forty patients with liver cirrhosis and 272 relatively healthy participants of both of nationalities were involved into research. АВ0, MNS, P1, CDE systems of erythrocytes of venous blood were investigated. For the comparison of the frequenc... Толығырақ
2016 жыл | Шығарылым: 5 | Беттер: 80-89
PSYCHOTHERAPEUTIC REHABILITATION AND NORMALIZATION OF PSYCHOEMOTIONAL AND FUNCTIONAL CONDITION OF PATIENTS WITH PAIN SYNDROMES IN BRAIN ORGANIC LESIONS
Background. Psychoemotional violations impede adequate recovery of neurological function in patients with pain syndromes on a background of central nervous system, enhance their social and domestic roles, as well as substantially reduce the quality of life in patients.
Aim: to increase the efficiency of the rehabilitation of patients with pain syndromes on a background of organic defeat CNS.
Methods. The study has a prospective, comparative open character. The results of psychological rehabilitation were analyzed in 500 patients with stroke, head injury and suffering pain syndromes... Толығырақ
Aim: to increase the efficiency of the rehabilitation of patients with pain syndromes on a background of organic defeat CNS.
Methods. The study has a prospective, comparative open character. The results of psychological rehabilitation were analyzed in 500 patients with stroke, head injury and suffering pain syndromes... Толығырақ
2016 жыл | Шығарылым: 5 | Беттер: 64-79
RNA SEQUENCING OF SQUAMOUS ESOPHAGEAL CANCER: FROM THE COLLECTION OF THE BIOMATERIAL UNTIL SEQUENCING ON HISEQ2000
The squamous esophageal cancer is a disease which is highly frequent in Kazakhstan, the frequency of the disease is 10,1:100 000. In the mortality structure esophageal cancer takes place among men the 5th place, among women the 9th place in the Republic of Kazakhstan. The molecular mechanisms which contribute to the initiation and progression of the cancer pathology are not investigated enough. Nevertheless, the lack of the sensitive and specific biomarkers for the diagnosis of the cancer diseases, underlines about the necessity of the additional research works to study about the development o...
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2016 жыл | Шығарылым: 5 | Беттер: 53-63
DEVELOPMENT OF HALOPLEX PANEL AND PREPARATION OF DNA LIBRARIES FOR TARGETED SEQUENCING OF CARDIAC ARRHYTHMIAS
Method of preparation of custom HaloPlex cardiogenetic panel (Agilent Technologies) and method of preparation of DNA libraries for targeted sequencing of 96 genes associated with cardiac arrhythmias were described in details in this article. SureDesign Online Design software (Agilent Technologies) was used to create the HaloPlex panel. Final design was developed for Illumina platform using Human Genome version 19, GRCh 37. 19958 amplicons were generated by the program, 99,46% of all target regions were covered successfully. DNA libraries were prepared for 48 samples using t...
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2016 жыл | Шығарылым: 5 | Беттер: 43-52