АТЕРОГЕНЕЗ И ВОСПАЛЕНИЕ
Введение: В статье представлены, теории развития атеросклероза и современные взгляды на роль воспаления в атерогенезе. На основании анализа современных книг, изданий, публикаций, мнений отечественных и зарубежных учёных в статье представлены воспалительная теория атеросклероза, роль цитокинов в развитии атеросклероза, взаимодействие липидной и воспалительной теории атерогенеза, формирование атеросклеротической бляшки. Фундаментальные исследования по молекулярной биологии, иммунологии, генетике значительно расширили понятие о патогенезе атеросклероза.
Цель: проведение поиска литературы п... Толығырақ
Цель: проведение поиска литературы п... Толығырақ
2016 жыл | Шығарылым: 1 | Беттер: 24-39
ОПИСАТЕЛЬНАЯ СТАТИСТИКА С ИСПОЛЬЗОВАНИЕМ ПАКЕТОВ СТАТИСТИЧЕСКИХ ПРОГРАММ STATISTICA И SPSS
В настоящей работе представлены основные методы предварительной статистической обработки данных с использованием программного обеспечения Statistica и SPSS для начинающих исследователей. Описаны различные типы данных, встречающихся в биомедицинских исследованиях, параметры нормального распределения количественных признаков, способы графического представления количественных результатов и методы проверки типа распределения. Настоящая статья призвана дать общие сведения об описательной статистике и проверке распределения данных, и не заменяет прочтения специализированной литературы по статистике ...
Толығырақ
2016 жыл | Шығарылым: 1 | Беттер: 7-23
ДЕФИЦИТ АЛЬФА-1 - АНТИТРИПСИНА И ХРОНИЧЕСКАЯ ОБСТРУКТИВНАЯ БОЛЕЗНЬ ЛЕГКИХ
Introduction. Alpha-1-antitrypsin deficiency (AATD) is a genetic disorder that manifests as pulmonary emphysema, liver cirrhosis and, rarely, as the skin disease panniculitis, and is characterized by low serum levels of AAT, the main protease inhibitor (PI) in human serum. The prevalence in Western Europe and in the USA is estimated at approximately 1 in 2,500 and 1 : 5,000 newborns, and is highly dependent on the Scandinavian descent within the population.
Chronic obstructive pulmonary disease (COPD) is one of the most essential causes of morbidity and mortality... Толығырақ
Chronic obstructive pulmonary disease (COPD) is one of the most essential causes of morbidity and mortality... Толығырақ
2016 жыл | Шығарылым: 1 | Беттер: 127-136
ФОРМИРОВАНИЕ ПРОФЕССИОНАЛЬНЫХ КОМПЕТЕНЦИЙ СОЦИАЛЬНОГО РАБОТНИКА ПРИ ОКАЗАНИИ СОЦИАЛЬНЫХ УСЛУГ В СИСТЕМЕ ЗДРАВООХРАНЕНИЯ РЕСПУБЛИКИ КАЗАХСТАН
2015 жыл | Шығарылым: 6 | Беттер: 147-158
ИЗУЧЕНИЕ СОСТОЯНИЯ ВНУТРИГЛАЗНЫХ СТРУКТУР ПОСЛЕ ИНТРАВИТРЕАЛЬНОГО ВВЕДЕНИЯ ХИТОЗАНОВОЙ ПЛЁНКИ, НАСЫЩЕННОЙ 5-ФУ В ЭКСПЕРИМЕНТЕ
2015 жыл | Шығарылым: 6 | Беттер: 133-146
ASSESSMENT OF ANTHROPOMETRIC CHARACTERISTICS IN PATIENTS WITH CORONARY ARTERY DISEASE IN KAZAKHSTAN: DATA FROM A PROSPECTIVE CROSS-SECTIONAL STUDY, SINGLE-CENTER EXPERIENCE
2025 жыл | Шығарылым: 5 | Беттер: 63-69
ASSESSMENT OF THE EFFECTIVENESS OF MEASURES TO PREVENT COMPLICATIONS OF SURGICAL TREATMENT IN PATIENTS WITH OCCLUSION OF THE AORTO-ILIAC SEGMENT
2025 жыл | Шығарылым: 5 | Беттер: 70-77
EVALUATION OF QUALITY OF LIFE IN PATIENTS AFTER SURGICAL TREATMENT OF POSTOPERATIVE VENTRAL HERNIAS
2025 жыл | Шығарылым: 5 | Беттер: 78-86
ACID–BASE BALANCE AND GAS EXCHANGE IN PATIENTS WITH DRUG-RESISTANT EPILEPSY DURING THE PERIOPERATIVE PERIOD: THE ROLE OF CLINICAL CHARACTERISTICS AND THERAPY
2025 жыл | Шығарылым: 5 | Беттер: 87-94
COMPARATIVE ASSESSMENT OF CANDIDA SPP. SUSCEPTIBILITY AND RESISTANCE TO ANTIFUNGAL AGENTS BY BIOLOGICAL MATERIAL TYPE
2025 жыл | Шығарылым: 5 | Беттер: 95-102
PSYCHOTHERAPEUTIC REHABILITATION AND NORMALIZATION OF PSYCHOEMOTIONAL AND FUNCTIONAL CONDITION OF PATIENTS WITH PAIN SYNDROMES IN BRAIN ORGANIC LESIONS
Background. Psychoemotional violations impede adequate recovery of neurological function in patients with pain syndromes on a background of central nervous system, enhance their social and domestic roles, as well as substantially reduce the quality of life in patients.
Aim: to increase the efficiency of the rehabilitation of patients with pain syndromes on a background of organic defeat CNS.
Methods. The study has a prospective, comparative open character. The results of psychological rehabilitation were analyzed in 500 patients with stroke, head injury and suffering pain syndromes... Толығырақ
Aim: to increase the efficiency of the rehabilitation of patients with pain syndromes on a background of organic defeat CNS.
Methods. The study has a prospective, comparative open character. The results of psychological rehabilitation were analyzed in 500 patients with stroke, head injury and suffering pain syndromes... Толығырақ
2016 жыл | Шығарылым: 5 | Беттер: 64-79
RNA SEQUENCING OF SQUAMOUS ESOPHAGEAL CANCER: FROM THE COLLECTION OF THE BIOMATERIAL UNTIL SEQUENCING ON HISEQ2000
The squamous esophageal cancer is a disease which is highly frequent in Kazakhstan, the frequency of the disease is 10,1:100 000. In the mortality structure esophageal cancer takes place among men the 5th place, among women the 9th place in the Republic of Kazakhstan. The molecular mechanisms which contribute to the initiation and progression of the cancer pathology are not investigated enough. Nevertheless, the lack of the sensitive and specific biomarkers for the diagnosis of the cancer diseases, underlines about the necessity of the additional research works to study about the development o...
Толығырақ
2016 жыл | Шығарылым: 5 | Беттер: 53-63
DEVELOPMENT OF HALOPLEX PANEL AND PREPARATION OF DNA LIBRARIES FOR TARGETED SEQUENCING OF CARDIAC ARRHYTHMIAS
Method of preparation of custom HaloPlex cardiogenetic panel (Agilent Technologies) and method of preparation of DNA libraries for targeted sequencing of 96 genes associated with cardiac arrhythmias were described in details in this article. SureDesign Online Design software (Agilent Technologies) was used to create the HaloPlex panel. Final design was developed for Illumina platform using Human Genome version 19, GRCh 37. 19958 amplicons were generated by the program, 99,46% of all target regions were covered successfully. DNA libraries were prepared for 48 samples using t...
Толығырақ
2016 жыл | Шығарылым: 5 | Беттер: 43-52
DETERMINATION OF GENETIC VARIANTS ASSOCIATED WITH HYPERTENSION, OBESITY AND DIABETES IN KAZAKH POPULATION TO STUDY INTERACTION OF GENETIC VARIANTS AND METABOLOME
In this work genetic variants associated with hypertension, obesity and diabetes were characterized, and genomic data of 60 samples were compared using Т-HOD (The Text-mined Hypertension, Obesity and Diabetes candidate gene database (T-HOD) international database.
Genetic variants extracted from whole genomes and exomes, and associated with hypertension, obesity and diabetes based on PolyPhen2 and SIFT algorithmic predictors of mutation pathogenicity were analyzed. Seven genetic variants were detected in GHRL (rs4684677), MTHFR (rs1801133), OPRM1 (rs17999... Толығырақ
Genetic variants extracted from whole genomes and exomes, and associated with hypertension, obesity and diabetes based on PolyPhen2 and SIFT algorithmic predictors of mutation pathogenicity were analyzed. Seven genetic variants were detected in GHRL (rs4684677), MTHFR (rs1801133), OPRM1 (rs17999... Толығырақ
2016 жыл | Шығарылым: 5 | Беттер: 30-42
REPORT ABOUT THE CONFERENCE: THE INTERNATIONAL WОRLD HEALTH ORGANIZATION CONSULTATION ON NUTRITION AND PREGNANCY (27-28 June 2016, RIGA, LATVIA)
27-28 June 2016, Riga, Latvia hosted the International WHO consultation on nutrition and pregnancy, with participation of experts in the field of maternal and child health and the WHO Collaborating Centers from Poland, Latvia, Lithuania, Estonia, Italy, the UK, Kazakhstan, Tajikistan, Uzbekistan, Kyrgyzstan, Georgia, Armenia and Moldova. The key problems of women's health and nutrition, according to speakers from different countries are the following: the growth of overweight and obesity among women, excessive weight gain during pregnancy, low rates of exclusive breastfeeding in the first ...
Толығырақ
2016 жыл | Шығарылым: 4 | Беттер: 166-172