МОРФОЛОГИЧЕСКИЕ ИЗМЕНЕНИЯ ЛЕГКИХ ПРИ ВОЗДЕЙСТВИИ ПРОМЫШЛЕННОЙ ХРИЗОТИЛСОДЕРЖАЩЕЙ ПЫЛИ
Органы дыхания напрямую взаимодействуют с атмосферным воздухом и это ведет к проникновению таких вредных субстанций, как газ, туман, дым, пыль и аэрозоли в легкие. Пыль является наиболее важным фактором загрязнения воздуха на современном индустриальном предприятии и развитии последующих дисфункций легких.
Морфологический метод исследования бронхиально-легочной системы является критерием оценки патогенных свойств вышеперечисленных вредных веществ. Этот метод применяется при гигиеническом нормировании промышленных аэрозолей.
В последние годы отмечается рост про...
Толығырақ
2015 жыл | Шығарылым: 2 | Беттер: 30-38
СОВРЕМЕННОЕ ПРЕДСТАВЛЕНИЕ О МОЛЕКУЛЯРНЫХ МЕХАНИЗМАХ ДЕЙСТВИЙ МЕТФОРМИНА
Обзор посвящен анализу молекулярных механизмов действия метформина, широко применяемого во всем мире, антидиабетического средства. Кроме гипогликемического действия у метформина обнаружен ряд плейотропных эффектов, в частности противоопухолевый. <span style="border-width: 1pt; border-color: windowtext;">Эффект метформина на пролиферацию раковых клеток связан с активацией AMPK и угнетением </span><span style="border-width: 1pt; border-color: windowtext;">mTOR</span><span style="border-width: 1pt; border-color: windowtext;">, который иг...
Толығырақ
2015 жыл | Шығарылым: 2 | Беттер: 19-29
ПОПЕРЕЧНЫЕ (ОДНОМОМЕНТНЫЕ) ИССЛЕДОВАНИЯ В ЗДРАВООХРАНЕНИИ
В настоящей работе представлены основные принципы планирования, проведения и статистической обработки данных поперечных (одномоментных) исследований в здравоохранении. Приведены практические примеры расчета размера выборки и оценки связи между факторами риска с помощью онлайн-калькуляторов и пакета для обработки эпидемиологических данных Epi Info. Авторы представляют практические примеры использования поперечных исследований в литературе, а также достоинства и недостатки данного типа исследований. Настоящая статья призвана дать общие сведения о поперечных исследованиях, и не заменяет п...
Толығырақ
2015 жыл | Шығарылым: 2 | Беттер: 5-18
ХИРУРГИЧЕСКОЕ ЛЕЧЕНИЕ ВНУТРИМОЗГОВЫХ КРОВОИЗЛИЯНИЙ У БЕРЕМЕННЫХ ЖЕНЩИН
Возникновение неотложных нейрохирургических
состояний у беременных женщин является сложной мультидисциплинарной проблемой,
для решения которой требуется участие специалистов нескольких смежных
специальностей.
Толығырақ
2015 жыл | Шығарылым: 1 | Беттер: 77-80
МОДЕЛЬ УПРАВЛЕНИЯ МОТИВАЦИЕЙ МЕДИЦИНСКОГО ПЕРСОНАЛА НА ПРИМЕРЕ РЕГИОНАЛЬНОГО ОНКОЛОГИЧЕСКОГО ДИСПАНСЕРА ГОРОДА СЕМЕЙ
В статье представлена модель мотивационного управления медицинским персоналом Регионального онкологического диспансера г. Семей, на базе которого находится кафедра онкологии и радиологии медицинского университета имени д.м.н., профессора Д.Р. Мусинова и проходят обучение по программе резидентура, магистратура, Phd докторантура. Мотивация персонала освещена в свете реализации Программы развития онкологической помощи на 2012-2016 года, включая развитие ядерной медицины. Создание высокоэффективных и мотивированных команд, в том числе и в лечебно-профилактических учреждениях, позволит повысить про...
Толығырақ
2015 жыл | Шығарылым: 1 | Беттер: 70-76
COMPARATIVE EVALUATION OF BLOOD COLLECTION TUBES AND EXTRACTION METHODS FOR CIRCULATING TUMOR DNA
2025 жыл | Шығарылым: 6 | Беттер: 7-13
INFLUENCE OF SEX HORMONE-BINDING GLOBULIN (SHBG) ON THE LEVEL OF FREE TESTOSTERONE FRACTION IN OLDER OVERWEIGHT MEN
2025 жыл | Шығарылым: 6 | Беттер: 14-20
ASSESSMENT OF THE PROBABILITY OF DEVELOPING CARDIORENAL SYNDROME TYPE 2 DEPENDING ON POTENTIAL BIOMARKERS IN PEDIATRIC PATIENTS
2025 жыл | Шығарылым: 6 | Беттер: 21-29
MORPHO-GENETIC VARIABILITY IN MYOCARDIAL TISSUE AFTER SEPTAL MYECTOMY IN PATIENTS WITH OBSTRUCTIVE HYPERTROPHIC CARDIOMYOPATHY: A FOUR-CASE SERIES STUDY
2025 жыл | Шығарылым: 6 | Беттер: 30-37
CLINICAL EFFICACY OF SELECTIVE PLASMA FILTRATION (EVACLIO) IN CARDIOVASCULAR COMPLICATIONS: A CASE SERIES FROM THE HEART CENTER KAZAKHSTAN
2025 жыл | Шығарылым: 6 | Беттер: 38-46
RNA SEQUENCING OF SQUAMOUS ESOPHAGEAL CANCER: FROM THE COLLECTION OF THE BIOMATERIAL UNTIL SEQUENCING ON HISEQ2000
The squamous esophageal cancer is a disease which is highly frequent in Kazakhstan, the frequency of the disease is 10,1:100 000. In the mortality structure esophageal cancer takes place among men the 5th place, among women the 9th place in the Republic of Kazakhstan. The molecular mechanisms which contribute to the initiation and progression of the cancer pathology are not investigated enough. Nevertheless, the lack of the sensitive and specific biomarkers for the diagnosis of the cancer diseases, underlines about the necessity of the additional research works to study about the development o...
Толығырақ
2016 жыл | Шығарылым: 5 | Беттер: 53-63
DEVELOPMENT OF HALOPLEX PANEL AND PREPARATION OF DNA LIBRARIES FOR TARGETED SEQUENCING OF CARDIAC ARRHYTHMIAS
Method of preparation of custom HaloPlex cardiogenetic panel (Agilent Technologies) and method of preparation of DNA libraries for targeted sequencing of 96 genes associated with cardiac arrhythmias were described in details in this article. SureDesign Online Design software (Agilent Technologies) was used to create the HaloPlex panel. Final design was developed for Illumina platform using Human Genome version 19, GRCh 37. 19958 amplicons were generated by the program, 99,46% of all target regions were covered successfully. DNA libraries were prepared for 48 samples using t...
Толығырақ
2016 жыл | Шығарылым: 5 | Беттер: 43-52
DETERMINATION OF GENETIC VARIANTS ASSOCIATED WITH HYPERTENSION, OBESITY AND DIABETES IN KAZAKH POPULATION TO STUDY INTERACTION OF GENETIC VARIANTS AND METABOLOME
In this work genetic variants associated with hypertension, obesity and diabetes were characterized, and genomic data of 60 samples were compared using Т-HOD (The Text-mined Hypertension, Obesity and Diabetes candidate gene database (T-HOD) international database.
Genetic variants extracted from whole genomes and exomes, and associated with hypertension, obesity and diabetes based on PolyPhen2 and SIFT algorithmic predictors of mutation pathogenicity were analyzed. Seven genetic variants were detected in GHRL (rs4684677), MTHFR (rs1801133), OPRM1 (rs17999... Толығырақ
Genetic variants extracted from whole genomes and exomes, and associated with hypertension, obesity and diabetes based on PolyPhen2 and SIFT algorithmic predictors of mutation pathogenicity were analyzed. Seven genetic variants were detected in GHRL (rs4684677), MTHFR (rs1801133), OPRM1 (rs17999... Толығырақ
2016 жыл | Шығарылым: 5 | Беттер: 30-42
REPORT ABOUT THE CONFERENCE: THE INTERNATIONAL WОRLD HEALTH ORGANIZATION CONSULTATION ON NUTRITION AND PREGNANCY (27-28 June 2016, RIGA, LATVIA)
27-28 June 2016, Riga, Latvia hosted the International WHO consultation on nutrition and pregnancy, with participation of experts in the field of maternal and child health and the WHO Collaborating Centers from Poland, Latvia, Lithuania, Estonia, Italy, the UK, Kazakhstan, Tajikistan, Uzbekistan, Kyrgyzstan, Georgia, Armenia and Moldova. The key problems of women's health and nutrition, according to speakers from different countries are the following: the growth of overweight and obesity among women, excessive weight gain during pregnancy, low rates of exclusive breastfeeding in the first ...
Толығырақ
2016 жыл | Шығарылым: 4 | Беттер: 166-172
MODERN LAVAGE OF THE GASTROINTESTINAL TRACT FROM THE PERSPECTIVE OF THE QUALITY OF DIAGNOSIS AND TREATMENT IN ENDOSCOPIC, BARIATRIC SURGERY (LITERATURE REVIEW)
Introduction. The issue of quality lavage for the gastrointestinal tract before an abdominal surgery and endoscopic examination is of paramount significance, especially in patients with visceral obesity.
The aim of the study is to study historical aspects of intestinal cleansing, identify optimal ways to lavage and define its tolerability by patients.
Research methods. The review examines the effectiveness of different lavage techniques and patients’ preparation before surgeries and endoscopic examinations. The analysis of 77 sources relevant to the results of the study is also inc... Толығырақ
The aim of the study is to study historical aspects of intestinal cleansing, identify optimal ways to lavage and define its tolerability by patients.
Research methods. The review examines the effectiveness of different lavage techniques and patients’ preparation before surgeries and endoscopic examinations. The analysis of 77 sources relevant to the results of the study is also inc... Толығырақ
2016 жыл | Шығарылым: 4 | Беттер: 145-165