СОВРЕМЕННОЕ ПРЕДСТАВЛЕНИЕ О МОЛЕКУЛЯРНЫХ МЕХАНИЗМАХ ДЕЙСТВИЙ МЕТФОРМИНА
Обзор посвящен анализу молекулярных механизмов действия метформина, широко применяемого во всем мире, антидиабетического средства. Кроме гипогликемического действия у метформина обнаружен ряд плейотропных эффектов, в частности противоопухолевый. <span style="border-width: 1pt; border-color: windowtext;">Эффект метформина на пролиферацию раковых клеток связан с активацией AMPK и угнетением </span><span style="border-width: 1pt; border-color: windowtext;">mTOR</span><span style="border-width: 1pt; border-color: windowtext;">, который иг...
Толығырақ
2015 жыл | Шығарылым: 2 | Беттер: 19-29
ПОПЕРЕЧНЫЕ (ОДНОМОМЕНТНЫЕ) ИССЛЕДОВАНИЯ В ЗДРАВООХРАНЕНИИ
В настоящей работе представлены основные принципы планирования, проведения и статистической обработки данных поперечных (одномоментных) исследований в здравоохранении. Приведены практические примеры расчета размера выборки и оценки связи между факторами риска с помощью онлайн-калькуляторов и пакета для обработки эпидемиологических данных Epi Info. Авторы представляют практические примеры использования поперечных исследований в литературе, а также достоинства и недостатки данного типа исследований. Настоящая статья призвана дать общие сведения о поперечных исследованиях, и не заменяет п...
Толығырақ
2015 жыл | Шығарылым: 2 | Беттер: 5-18
ХИРУРГИЧЕСКОЕ ЛЕЧЕНИЕ ВНУТРИМОЗГОВЫХ КРОВОИЗЛИЯНИЙ У БЕРЕМЕННЫХ ЖЕНЩИН
Возникновение неотложных нейрохирургических
состояний у беременных женщин является сложной мультидисциплинарной проблемой,
для решения которой требуется участие специалистов нескольких смежных
специальностей.
Толығырақ
2015 жыл | Шығарылым: 1 | Беттер: 77-80
МОДЕЛЬ УПРАВЛЕНИЯ МОТИВАЦИЕЙ МЕДИЦИНСКОГО ПЕРСОНАЛА НА ПРИМЕРЕ РЕГИОНАЛЬНОГО ОНКОЛОГИЧЕСКОГО ДИСПАНСЕРА ГОРОДА СЕМЕЙ
В статье представлена модель мотивационного управления медицинским персоналом Регионального онкологического диспансера г. Семей, на базе которого находится кафедра онкологии и радиологии медицинского университета имени д.м.н., профессора Д.Р. Мусинова и проходят обучение по программе резидентура, магистратура, Phd докторантура. Мотивация персонала освещена в свете реализации Программы развития онкологической помощи на 2012-2016 года, включая развитие ядерной медицины. Создание высокоэффективных и мотивированных команд, в том числе и в лечебно-профилактических учреждениях, позволит повысить про...
Толығырақ
2015 жыл | Шығарылым: 1 | Беттер: 70-76
СОСТОЯНИЕ КОАГУЛЯЦИОННОГО ЗВЕНА ГЕМОСТАЗА У ЖЕНЩИН ГРУППЫ РИСКА ПРИ ПОСЛЕРОДОВЫХ КРОВОТЕЧЕНИЯХ В ЗАВИСИМОСТИ ОТ ПАРИТЕТА РОДОВ
Акушерские кровотечения остаются актуальной проблемой современного акушерства и занимают ведущее место в структуре материнской смертности во многих странах мира. Немалый вклад в летальные исходы от данной патологии в Республике Казахстан вносят многорожавшие женщины. Более 2/3 кровопотерь, в том числе угрожающих жизни матери, связано с нарушениями в системе гемостаза.
Толығырақ
2015 жыл | Шығарылым: 1 | Беттер: 60-69
ТРАВМЫ В СЛЕДСТВИИ ПАДЕНИЯ У ЛИЦ ПОЖИЛОГО И СТАРЧЕСКОГО ВОЗРАСТА
2012 жыл | Шығарылым: 6 | Беттер: 74-76
СТЕНОКАРДИЯ МЕН АЯҚ ТАМЫРЛАРЫНЫҢ ОБЛИТЕРАЦИЯЛЫҚ АТЕРОСКЛЕРОЗЫ ҚАТАР ЖҮРЕТІН НАУҚАСҚА КОРАКСАНАУ ҚОЛДАНУДЫҢ НӘТИЖЕЛІЛІГІ
2012 жыл | Шығарылым: 6 | Беттер: 70-71
ҚОСАЛҚЫ ЖАРАҚАТТАРЫ БАР НАУҚАСТАРДЫҢ ТРОМБОЭМБОЛИЯЛЫҚ АСҚЫНУЛАРЫНЫҢ ҚАЗІРГІ ЗАМАНҒЫ АЛДЫН АЛУ МҮМКІНДІКТЕРІ
2012 жыл | Шығарылым: 6 | Беттер: 68-69
ӨКПЕНІҢ ІРІҢ ДЕСТРУКЦИЯСЫНА ЕМДЕУДЕ ҚОЛДАНЫЛГАН СЕГМЕНТАРЛЫҚ-СУБСЕГМЕНТАРЛЫҚ БРОНХИЯЛЫҚ АҒАШТЫҢ ФИБРОБРОНХОСКОПИЯЛЫҚ СҮРЕТІ
2012 жыл | Шығарылым: 6 | Беттер: 65-67
UPTAKE BARRIERS TO THE TREATMENT OF PRECANCEROUS CERVICAL DISEASES
Background. The malignant cervical tumors are the second leading cause of female mortality in the Republic of Kazakhstan. Currently, there is a growth of untreated precancerous cervical diseases which have a potential to develop into cervical cancer. In this connection, the question arises what barriers exist to the treatment of precancerous cervical diseases.
Objective: To identify uptake barriers to the treatment of precancerous cervical diseases.
Materials and methods. A cross-sectional study with random sampling strategy. Sampling - 404 women of childbearing age, ... Толығырақ
Objective: To identify uptake barriers to the treatment of precancerous cervical diseases.
Materials and methods. A cross-sectional study with random sampling strategy. Sampling - 404 women of childbearing age, ... Толығырақ
2017 жыл | Шығарылым: 1 | Беттер: 122-132
ACCESSIBILITY IN THE ASSESSMENT OF PEOPLE WITH DISABILITIES
Background: Social protection of disabled persons has a special place in the government system of social support. In order to prepare the ground for the ratification by Kazakhstan of the Convention on the Rights of Persons with Disabilities Plan was developed to ensure the rights and improve the quality of life of people with disabilities in the years 2012-2018, which will improve the system of social protection and improve the efficiency of social services.
The aim of the research is to study satisfaction of disabled due to rheumatic diseases (RD) quality health and socia... Толығырақ
The aim of the research is to study satisfaction of disabled due to rheumatic diseases (RD) quality health and socia... Толығырақ
2017 жыл | Шығарылым: 1 | Беттер: 112-121
WAYS OF IMPROVING THE QUALITY AND ENHANCING THE ECONOMIC EFFICIENCY OF NATIONAL SCREENING PROGRAM FOR THE EARLY DETECTION OF ONCOLOGICAL DISEASES (FOR EXAMPLE PAVLODAR REGION). STUDY PROTOCOL.
Introduction. In Kazakhstan, the national screening program for the early detection of diseases was introduced in 2011. It is noted the low efficiency of the National screening program, the effectiveness of screening is not monitored on the basis of the recommendations on the effectiveness of early detection of cancer and their successful treatment.
Methods / design. The purpose of this study: to develop measures to improve results and increase cost-effectiveness of national screening program for early detection of oncological diseases. Studied nosologies: cervical cancer, breast ... Толығырақ
Methods / design. The purpose of this study: to develop measures to improve results and increase cost-effectiveness of national screening program for early detection of oncological diseases. Studied nosologies: cervical cancer, breast ... Толығырақ
2017 жыл | Шығарылым: 1 | Беттер: 97-111
VIDEO ENDOSCOPE TECHNOLOGY WITH MINIMALLY INVASIVE SURGICAL TREATMENT OF PATIENTS WITH CORONARY HEART DISEASE: CASE SERIES REPORT
Coronary artery bypass surgery with using endoscopic technology is the most recent trend of surgical treatment of coronary heart disease.
The purpose of this work is to present the experience of the 8 video assistant cardiac surgery in a "Pavlodar Regional Cardiological Center" for the period from 2012 to 2016.
Materials and methods. Design - case series. All 8 patients underwent minimal-ivasive direct coronary artery bypass off pump, with endoscopic release of the left internal mammary artery (LIMA), and making anastomosis LIMA to left anterior desc... Толығырақ
The purpose of this work is to present the experience of the 8 video assistant cardiac surgery in a "Pavlodar Regional Cardiological Center" for the period from 2012 to 2016.
Materials and methods. Design - case series. All 8 patients underwent minimal-ivasive direct coronary artery bypass off pump, with endoscopic release of the left internal mammary artery (LIMA), and making anastomosis LIMA to left anterior desc... Толығырақ
2017 жыл | Шығарылым: 1 | Беттер: 87-96
COMMENTS ON 2016 EUROPEAN GUIDELINES FOR THE MANAGEMENT OF ATRIAL FIBRILLATION: NEW ASPECTS FOR PHYSICIANS
Updated European guidelines for the management of atrial fibrillation were published on the 27 of August, 2016. This document is remarkable for new recommendations, especially about anticoagulation therapy. Key points of these guidelines and the possibility of their use in our country are described in the article.
Objective: to find out essential evidence-based key points of the 2016 guidelines and to investigate the possibility of their use in Kazakhstan.
Materials and methods: To achieve these goals major differences between 2016, 2012, 2010 guidelines were analyze... Толығырақ
Objective: to find out essential evidence-based key points of the 2016 guidelines and to investigate the possibility of their use in Kazakhstan.
Materials and methods: To achieve these goals major differences between 2016, 2012, 2010 guidelines were analyze... Толығырақ
2017 жыл | Шығарылым: 1 | Беттер: 74-86