ПРОБЛЕМЫ ДИАГНОСТИКИ, ОЦЕНКИ ТЯЖЕСТИ, ПРОГНОЗИРОВАНИЯ ИСХОДОВ И ЛЕЧЕНИЯ ХРОНИЧЕСКОЙ ОБСТРУКТИВНОЙ БОЛЕЗНИ ЛЕГКИХ
2013 жыл | Шығарылым: 2 | Беттер: 13-15
СЛУЧАЙ РАЗВИТИЯ ПРОГРЕССИРУЮЩЕЙ МУЛЬТИФОКАЛЬНОЙ ЛЕЙКОЭНЦЕФАЛОПАТИИ (ПМЛ) У БОЛЬНОГО С СОЧЕТАННОЙ ПАТОЛОГИЕЙ ВИЧ И ТУБЕРКУЛЕЗ
Продемонстрированный нами случай быстро прогрессирующей мультифокальной лейкоэнцефалопатии с ле-тальным исходом на фоне выраженного иммунодефицита у больного СПИДом, подтверждает необходимость свое-временной антиретровирусной терапии, как единственного способа профилактики данной патологии с неразрабо-танными методами специфической профилактики и этиотропного лечения.
Толығырақ
2013 жыл | Шығарылым: 1 | Беттер: 71-73
ЦЕНТРАЛЬНОЕ ВЕНОЗНОЕ ДАВЛЕНИЕ И МОРФОЛОГИЧЕСКИЕ ИЗМЕНЕНИЯ В ОРГАНАХ КРОЛИКОВ ПРИ ПРОВЕДЕНИИ ВНУТРИВЕННЫХ ИНФУЗИЙ
Проведен опыт на 27 здоровых кроликах. 22-м кроликам проводилась внутривенная инфузия физиологического раствора в разных объемах. У всех 27 кроликов брались гистологические микропрепараты органов: головной мозг, сердце, легкие, печень и почки. У всех кроликов выявлено исходное отрицательное центральное венозное давление (ЦВД) от -4,8±0,9 до -10,2±1,6 мм водного столба. Введение изотонического раствора в объеме от 100 до 700 мл привело к повышению ЦВД от исходного отрицательного до 183,3±7,9 мм водного столба. При морфологической оценке изменений в органах умерших кроликов выявлено, что...
Толығырақ
2013 жыл | Шығарылым: 1 | Беттер: 78-79
CENTRAL VENOUS PRESSURE AND MORPHOLOGICAL CHANGES IN ORGANS OF RABBITS AT INTRAVENOUS INFUSION
Experiment was performed on 27 healthy rabbits. To 22 rabbits the intravenous infusion of normal saline solution was done in different amounts. At all 27 rabbits the histology preparations were taken: brain, heart, lungs, liver and kidneys. All rabbits showed negative initial central venous pressure (CVP) from -4,8±0,9 to - 10,2±1,6 mm of water column. Infusion of isotonic solution in a volume of 100 to 700 ml resulted in increased CVP from the original negative to 183,3±7,9 mm of water column. At morphological assessment of changes in the organs of dead rabbits was found that the seve...
Толығырақ
2013 жыл | Шығарылым: 1 | Беттер: 78-79
COMPARATIVE EVALUATION OF BLOOD COLLECTION TUBES AND EXTRACTION METHODS FOR CIRCULATING TUMOR DNA
2025 жыл | Шығарылым: 6 | Беттер: 7-13
INFLUENCE OF SEX HORMONE-BINDING GLOBULIN (SHBG) ON THE LEVEL OF FREE TESTOSTERONE FRACTION IN OLDER OVERWEIGHT MEN
2025 жыл | Шығарылым: 6 | Беттер: 14-20
GENETIC VARIANTS IN LIPID-ASSOCIATED GENES IN THE KAZAKHSTANI COHORT WITH ATHEROSCLEROSIS AND HYPERTRIGLYCERIDEMIA
2025 жыл | Шығарылым: 5 | Беттер: 7-15
CLONAL HEMATOPOIESIS WITH INDETERMINATE POTENTIAL IN TET2 AND DNMT3A AMONG KAZAKHSTANI INDIVIDUALS WITH ATHEROSCLEROTIC DISEASE
2025 жыл | Шығарылым: 5 | Беттер: 16-23
RNA SEQUENCING OF SQUAMOUS ESOPHAGEAL CANCER: FROM THE COLLECTION OF THE BIOMATERIAL UNTIL SEQUENCING ON HISEQ2000
The squamous esophageal cancer is a disease which is highly frequent in Kazakhstan, the frequency of the disease is 10,1:100 000. In the mortality structure esophageal cancer takes place among men the 5th place, among women the 9th place in the Republic of Kazakhstan. The molecular mechanisms which contribute to the initiation and progression of the cancer pathology are not investigated enough. Nevertheless, the lack of the sensitive and specific biomarkers for the diagnosis of the cancer diseases, underlines about the necessity of the additional research works to study about the development o...
Толығырақ
2016 жыл | Шығарылым: 5 | Беттер: 53-63
DEVELOPMENT OF HALOPLEX PANEL AND PREPARATION OF DNA LIBRARIES FOR TARGETED SEQUENCING OF CARDIAC ARRHYTHMIAS
Method of preparation of custom HaloPlex cardiogenetic panel (Agilent Technologies) and method of preparation of DNA libraries for targeted sequencing of 96 genes associated with cardiac arrhythmias were described in details in this article. SureDesign Online Design software (Agilent Technologies) was used to create the HaloPlex panel. Final design was developed for Illumina platform using Human Genome version 19, GRCh 37. 19958 amplicons were generated by the program, 99,46% of all target regions were covered successfully. DNA libraries were prepared for 48 samples using t...
Толығырақ
2016 жыл | Шығарылым: 5 | Беттер: 43-52
DETERMINATION OF GENETIC VARIANTS ASSOCIATED WITH HYPERTENSION, OBESITY AND DIABETES IN KAZAKH POPULATION TO STUDY INTERACTION OF GENETIC VARIANTS AND METABOLOME
In this work genetic variants associated with hypertension, obesity and diabetes were characterized, and genomic data of 60 samples were compared using Т-HOD (The Text-mined Hypertension, Obesity and Diabetes candidate gene database (T-HOD) international database.
Genetic variants extracted from whole genomes and exomes, and associated with hypertension, obesity and diabetes based on PolyPhen2 and SIFT algorithmic predictors of mutation pathogenicity were analyzed. Seven genetic variants were detected in GHRL (rs4684677), MTHFR (rs1801133), OPRM1 (rs17999... Толығырақ
Genetic variants extracted from whole genomes and exomes, and associated with hypertension, obesity and diabetes based on PolyPhen2 and SIFT algorithmic predictors of mutation pathogenicity were analyzed. Seven genetic variants were detected in GHRL (rs4684677), MTHFR (rs1801133), OPRM1 (rs17999... Толығырақ
2016 жыл | Шығарылым: 5 | Беттер: 30-42
REPORT ABOUT THE CONFERENCE: THE INTERNATIONAL WОRLD HEALTH ORGANIZATION CONSULTATION ON NUTRITION AND PREGNANCY (27-28 June 2016, RIGA, LATVIA)
27-28 June 2016, Riga, Latvia hosted the International WHO consultation on nutrition and pregnancy, with participation of experts in the field of maternal and child health and the WHO Collaborating Centers from Poland, Latvia, Lithuania, Estonia, Italy, the UK, Kazakhstan, Tajikistan, Uzbekistan, Kyrgyzstan, Georgia, Armenia and Moldova. The key problems of women's health and nutrition, according to speakers from different countries are the following: the growth of overweight and obesity among women, excessive weight gain during pregnancy, low rates of exclusive breastfeeding in the first ...
Толығырақ
2016 жыл | Шығарылым: 4 | Беттер: 166-172
MODERN LAVAGE OF THE GASTROINTESTINAL TRACT FROM THE PERSPECTIVE OF THE QUALITY OF DIAGNOSIS AND TREATMENT IN ENDOSCOPIC, BARIATRIC SURGERY (LITERATURE REVIEW)
Introduction. The issue of quality lavage for the gastrointestinal tract before an abdominal surgery and endoscopic examination is of paramount significance, especially in patients with visceral obesity.
The aim of the study is to study historical aspects of intestinal cleansing, identify optimal ways to lavage and define its tolerability by patients.
Research methods. The review examines the effectiveness of different lavage techniques and patients’ preparation before surgeries and endoscopic examinations. The analysis of 77 sources relevant to the results of the study is also inc... Толығырақ
The aim of the study is to study historical aspects of intestinal cleansing, identify optimal ways to lavage and define its tolerability by patients.
Research methods. The review examines the effectiveness of different lavage techniques and patients’ preparation before surgeries and endoscopic examinations. The analysis of 77 sources relevant to the results of the study is also inc... Толығырақ
2016 жыл | Шығарылым: 4 | Беттер: 145-165