ФОРМИРОВАНИЕ ОЧАГОВ Р53 СВЯЗАННОГО БЕЛКА 1 В ОПУХОЛЯХ ЩИТОВИДНОЙ ЖЕЛЕЗЫ: АКТИВАЦИЯ ГЕНЕТИЧЕСКОЙ НЕСТАБИЛЬНОСТИ В ТЕЧЕНИИ КАНЦЕРОГЕНЕЗА ЩИТОВИДНОЙ ЖЕЛЕЗЫ. ОБЗОР ЛИТЕРАТУРЫ
Введение: К настоящему времени достигнуты большие успехи в изучении молекулярно–клеточных механизмов канцерогенеза, установлении роли онкогенов и антионкогенов в развитии опухолей различной локализации, в том числе и РЩЖ. Подавляющее число доброкачественных и злокачественных опухолей щитовидной железы развивается из фолликулярного эпителия, которые имеют разную степень дифференцировки, разные морфогенетические и биохимические особенности, клиническое течение и прогноз.
Цель: проведение поиска научной информации по активации генетической нестабильности в течений канцерогенеза щитовидной ... Толығырақ
Цель: проведение поиска научной информации по активации генетической нестабильности в течений канцерогенеза щитовидной ... Толығырақ
2019 жыл | Шығарылым: 2 | Беттер: 25-37
ОРГАНИЗАЦИОННЫЕ ОСНОВЫ СКРИНИНГА КОЛОРЕКТАЛЬНОГО РАКА В МИРОВОЙ МЕДИЦИНСКОЙ ПРАКТИКЕ. ОБЗОР ЛИТЕРАТУРЫ
Актуальность. Рак ободочной и прямой кишки (колоректальный) является третьим по распространенности раком в мире. Он поддается скринингу, так как скрининговое исследование может быть осуществлено на предраковых, латентных, ранних и излечимых стадиях. При скрининге колоректального рака могут использоваться прямые или непрямые методы, применяемые произвольно или в структуре организованных программ. Большинство случаев колоректального рака диагностируется в возрасте старше 60 лет. Большинство программ скрининга относятся к лицам в возрасте 50-75 лет.
Цель обзора – Анализ подходов и р... Толығырақ
Цель обзора – Анализ подходов и р... Толығырақ
2019 жыл | Шығарылым: 2 | Беттер: 13-24
MODERN TENDENCY IN TREATMENT OF PATIENTS WITH SEVERE TRAUMATIC BRAIN INJURY. LITERARY REVIEW
Relevance: Carrying out of intensive therapy at severe traumatic brain injury is a complex of measures aimed on saving of the brain tissues and maintaining its functions. To achieve this goal, it is necessary to do timely diagnostics and monitoring of critical parameters - intracranial pressure and cerebral perfusion pressure; pathogenetically based therapy and nutritional support for critically ill patients.
Aim: The goal of this review was to find evidences of admissibility of use for such methods as control of cerebral perfusion pressure and intracranial pressure, anti-edematous thera... Толығырақ
Aim: The goal of this review was to find evidences of admissibility of use for such methods as control of cerebral perfusion pressure and intracranial pressure, anti-edematous thera... Толығырақ
2019 жыл | Шығарылым: 2 | Беттер: 5-12
ЛЕЧЕНИЕ ПОПЕРЕЧНОГО ПЛОСКОСТОПИЯ С HALLUX VALGUS ПРИ I и II ТИПЕ РАСПЛАСТАННОСТИ СТОПЫ
Введение. Статическая деформация переднего отдела стопы составляет до 80% среди ортопедической патологии стопы у взрослых. Патология вызывает значительное нарушение биомеханики всей нижней конечности, сопровождаясь болью в переднем отделе стопы, затруднение в подборе и ношении обуви, значительно снижает трудоспособность и качество жизни пациента. В связи с этим разработка технологии лечения статической деформации переднего отдела стопы, предусматривающей устранение Halluxvalgus, metatarsusprimavarus и плантарную девиацию центральных лучей стопы остается не полностью решенной и актуальной п...
Толығырақ
2019 жыл | Шығарылым: 1 | Беттер: 80-90
АНТИБИОТИКОРЕЗИСТЕНТНОСТЬ ШИГЕЛЛ НА СОВРЕМЕННОМ ЭТАПЕ
Введение. Одна из больших проблем практического здравоохранения на современном этапе – это рост антибиотикорезистентности шигелл к тем антибактериальным препаратам, которые широко сегодня используются в их лечении.
Цель исследования: изучить чувствительность штаммов Shigella spp., выделенных из кишечника больных острой дизентерией, к широко используемым в клинической практике антимикробным препаратам.
Материалы и методы. Проведен ретроспективный анализ 236 медицинских карт пациентов с диагнозом острой дизентерии, пролеченных на базе Городской инфекционной больница г. Астана за пе... Толығырақ
Цель исследования: изучить чувствительность штаммов Shigella spp., выделенных из кишечника больных острой дизентерией, к широко используемым в клинической практике антимикробным препаратам.
Материалы и методы. Проведен ретроспективный анализ 236 медицинских карт пациентов с диагнозом острой дизентерии, пролеченных на базе Городской инфекционной больница г. Астана за пе... Толығырақ
2019 жыл | Шығарылым: 1 | Беттер: 74-79
COMPARATIVE EVALUATION OF BLOOD COLLECTION TUBES AND EXTRACTION METHODS FOR CIRCULATING TUMOR DNA
2025 жыл | Шығарылым: 6 | Беттер: 7-13
INFLUENCE OF SEX HORMONE-BINDING GLOBULIN (SHBG) ON THE LEVEL OF FREE TESTOSTERONE FRACTION IN OLDER OVERWEIGHT MEN
2025 жыл | Шығарылым: 6 | Беттер: 14-20
GENETIC VARIANTS IN LIPID-ASSOCIATED GENES IN THE KAZAKHSTANI COHORT WITH ATHEROSCLEROSIS AND HYPERTRIGLYCERIDEMIA
2025 жыл | Шығарылым: 5 | Беттер: 7-15
CLONAL HEMATOPOIESIS WITH INDETERMINATE POTENTIAL IN TET2 AND DNMT3A AMONG KAZAKHSTANI INDIVIDUALS WITH ATHEROSCLEROTIC DISEASE
2025 жыл | Шығарылым: 5 | Беттер: 16-23
THE PREVALENCE OF REFRACTIVE ERRORSAMONG THE FIRST-YEAR STUDENTS OF SEMEY STATE MEDICAL UNIVERSITY
Background.Myopia is a high prevalent eye disease in the word and is a common cause of visionloss. Increasing myopiaprevalence among young population, including the students of medical universities, has raises scientific interest for this problem.
The aim of the study is to examine the prevalence of refractive errors among the first year medical students and to compare it with the World indicators.
Methods: A cross-sectional study including 598 students (1195 eyes). All the first year students, excluding the foreign students, have been examined. The statistically significan... Толығырақ
The aim of the study is to examine the prevalence of refractive errors among the first year medical students and to compare it with the World indicators.
Methods: A cross-sectional study including 598 students (1195 eyes). All the first year students, excluding the foreign students, have been examined. The statistically significan... Толығырақ
2016 жыл | Шығарылым: 2 | Беттер: 129-138
THE EXPERIENCE OF CORRECTION OF VASCULAR ENDOTHELIAL FUNCTION AND HEMOSTASIS IN PATIENTS WITH RECTAL CANCER
A valuable trend in modern oncology it is improving the conservative treatment of rectal cancer, as one of the most common and dangerous form of malignancies
The purpose of the research – identifying of opportunities for correction of endothelial dysfunction in patients with rectal cancer and assessment of its impact on the state of the hemostatic system and the risk of thrombotic complications.
Materials and methods. The study included 86 patients with rectal cancer, including 45 men (52.3%), 41 women (47.7%) aged 45 to 70 years (mean age 62,3±1,8 year... Толығырақ
The purpose of the research – identifying of opportunities for correction of endothelial dysfunction in patients with rectal cancer and assessment of its impact on the state of the hemostatic system and the risk of thrombotic complications.
Materials and methods. The study included 86 patients with rectal cancer, including 45 men (52.3%), 41 women (47.7%) aged 45 to 70 years (mean age 62,3±1,8 year... Толығырақ
2016 жыл | Шығарылым: 2 | Беттер: 118-128
MORPHOLOGICAL CHARACTERISTICS of granuloSA cells of mice ovarian under lindane exposure
Introduction. Analysis of materials that characterize the human environment in the Aral Sea, has shown a sharp increase of the chemical (pesticides, fertilizers, salt components, heavy metals) pollution of drinking water, air, soil, pesticide contamination of food products of plant and animal origin, fishery products.
Aim. Еvaluate the ultrastructural changes in granulosa cells of mice under the exposure of lindane pesticide in vitro.
Methods. The experimental work carried out in the Laboratory Centre of Microscopy Department of Life, Health and Environmental Sciences ... Толығырақ
Aim. Еvaluate the ultrastructural changes in granulosa cells of mice under the exposure of lindane pesticide in vitro.
Methods. The experimental work carried out in the Laboratory Centre of Microscopy Department of Life, Health and Environmental Sciences ... Толығырақ
2016 жыл | Шығарылым: 2 | Беттер: 106-117
THE FEATURES GENETIC POLYMORPHISM OF GENE LOCI AND MORPHO-PHYSIOLOGICAL TRAITS IN DUST PULMONARY DISEASE
Introduction. Features of the metabolism of most substances in the body are determined by a complex system of enzymatic reactions. Research results in the art can justify the criteria of individual risk prognosis of occupational diseases and the so-called "ecologically production or due to pathology," more versatile and given reason conduct prevention, medical monitoring of workers, professional orientation to solve the issues of rational employment of persons with specific genotypic and phenotypic characteristics of the organism.
Objective: To conduct analysis of the hereditar... Толығырақ
Objective: To conduct analysis of the hereditar... Толығырақ
2016 жыл | Шығарылым: 2 | Беттер: 93-105
FEATURES OF THE IMMUNE MECHANISMS OF THE WORKERS IN THEIR CONTACT WITH THE DUST OF MULLITE
Introduction. According to literature data, the primary mechanisms of cleansing the respiratory system from dust particles associated with monocyte-macrophage cell system as a front line of immune defense. The accumulation of metabolic cellular debris is a powerful antigenic stimulus, which determinant autoimmune and allergic mechanism development of the dust diseases of the Lungs.
The aim of this study was to evaluate the immune status of the body in conditions exposure industrial dust mullite with purpose of revealing early immunological criteria formation of bronchopulmonary pathology... Толығырақ
The aim of this study was to evaluate the immune status of the body in conditions exposure industrial dust mullite with purpose of revealing early immunological criteria formation of bronchopulmonary pathology... Толығырақ
2016 жыл | Шығарылым: 2 | Беттер: 84-92