Online ISSN: 3007-0244,
Print ISSN:  2410-4280
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КӨП ДӘРІЛЕРГЕ ТӨЗІМДІ ТУБЕРКУЛЕЗ. ӘДЕБИЕТТЕРГЕ ШОЛУ
Кіріспе. Дәріге төзімді туберкулез біздің заманымыздың жаһандық мәселелердің бірі болып табылады. ДДСҰ мәліметі бойынша жыл сайын жарты миллион көптеген дәріге төзімді туберкулездің жаңа жағдайы тіркеледі. Көптеген дәріге төзімді туберкулездің өлім-жітім көрсеткіші және емдеу құны жоғары.
Мақсат. Зерттеу мақсатымыз ТМД елдерінде, бүкіл әлемде және Қазақстанда көптеген дәріге төзімді туберкулез мәселелерін зерттеуге болды.
Зерттеу әдістері. Бұл шолуда КДТ ТБ негізгі мәселелері қаралды, 1999 жылдан 2016 жыл аралығындағы  ғылыми-зерттеу зерделенді. Ғылыми мақалаларды әдеби...
Толығырақ
2016 жыл | Шығарылым: 6 | Беттер: 179-192

RADIATION–INDUCED LUNG INJURY. LITERATURE REVIEW
Introduction. Despite the numerous data about results of morphological studies of lungs at the cellular and tissue levels in different radiation situations, and also regarding connection assessment of increasing bronchopulmonary diseases with the values of external and internal doses exposure during acute and long–term periods, hitherto not fully explored the association revealed pulmonary disorders with exposure to γ– and neutron radiation effects, it is not fully proven the value of radiation dose and duration of radiation influence on the nature of detectable pathology, there are no systemi...
Толығырақ
2016 жыл | Шығарылым: 6 | Беттер: 160-178

О НЕОБХОДИМОСТИ ВНЕДРЕНИЯ В ОБРАЗОВАТЕЛЬНЫЕ ПРОГРАММЫ ИНТЕРНАТУРЫ ПРОФЕССИОНАЛЬНЫХ СТАЖИРОВОК. ОБЗОР ЛИТЕРАТУРЫ
Введение: литературный обзор посвящен вопросу внедрения в образовательные программы интернатуры профессиональных стажировок на будущем рабочем месте. Данный вопрос освещается в контексте актуальной для системы высшего образования Казахстана проблемы, реализации дуального обучения.
Цель: обоснование необходимости внедрения в образовательные программы интернатуры профессиональных стажировок на основе результатов литературного обзора.
Материалы и методы: в статье представлены результаты аналитического обзора. Поиск литературы был осуществлен по тегу «профессиональная стажировка интер...
Толығырақ
2016 жыл | Шығарылым: 6 | Беттер: 146-159

PSYCHOTHERAPEUTIC REHABILITATION AND NORMALIZATION OF PSYCHOEMOTIONAL AND FUNCTIONAL CONDITION OF PATIENTS WITH PAIN SYNDROMES IN BRAIN ORGANIC LESIONS
Background. Psychoemotional violations impede adequate recovery of neurological function in patients with pain syndromes on a background of central nervous system, enhance their social and domestic roles, as well as substantially reduce the quality of life in patients.
Aim: to increase the efficiency of the rehabilitation of patients with pain syndromes on a background of organic defeat CNS.
Methods. The study has a prospective, comparative open character. The results of psychological rehabilitation were analyzed in 500 patients with stroke, head injury and suffering pain syndromes...
Толығырақ
2016 жыл | Шығарылым: 5 | Беттер: 64-79

RNA SEQUENCING OF SQUAMOUS ESOPHAGEAL CANCER: FROM THE COLLECTION OF THE BIOMATERIAL UNTIL SEQUENCING ON HISEQ2000
The squamous esophageal cancer is a disease which is highly frequent in Kazakhstan, the frequency of the disease is 10,1:100 000. In the mortality structure esophageal cancer takes place among men the 5th place, among women the 9th place in the Republic of Kazakhstan. The molecular mechanisms which contribute to the initiation and progression of the cancer pathology are not investigated enough. Nevertheless, the lack of the sensitive and specific biomarkers for the diagnosis of the cancer diseases, underlines about the necessity of the additional research works to study about the development o...
Толығырақ
2016 жыл | Шығарылым: 5 | Беттер: 53-63

DEVELOPMENT OF HALOPLEX PANEL AND PREPARATION OF DNA LIBRARIES FOR TARGETED SEQUENCING OF CARDIAC ARRHYTHMIAS
Method of preparation of custom HaloPlex cardiogenetic panel (Agilent Technologies) and method of preparation of DNA libraries for targeted sequencing of 96 genes associated with cardiac arrhythmias were described in details in this article. SureDesign Online Design software (Agilent Technologies) was used to create the HaloPlex panel. Final design was developed for Illumina platform using Human Genome version 19, GRCh 37. 19958 amplicons were generated by the program, 99,46% of all target regions were covered successfully. DNA libraries were prepared for 48 samples using t...
Толығырақ
2016 жыл | Шығарылым: 5 | Беттер: 43-52

DETERMINATION OF GENETIC VARIANTS ASSOCIATED WITH HYPERTENSION, OBESITY AND DIABETES IN KAZAKH POPULATION TO STUDY INTERACTION OF GENETIC VARIANTS AND METABOLOME
In this work genetic variants associated with hypertension, obesity and diabetes were characterized, and genomic data of 60 samples were compared using Т-HOD (The Text-mined Hypertension, Obesity and Diabetes candidate gene database (T-HOD) international database.
Genetic variants extracted from whole genomes and exomes, and associated with hypertension, obesity and diabetes based on PolyPhen2 and SIFT algorithmic predictors of mutation pathogenicity were analyzed. Seven genetic variants were detected in GHRL (rs4684677), MTHFR (rs1801133), OPRM1 (rs17999...
Толығырақ
2016 жыл | Шығарылым: 5 | Беттер: 30-42

REPORT ABOUT THE CONFERENCE: THE INTERNATIONAL WОRLD HEALTH ORGANIZATION CONSULTATION ON NUTRITION AND PREGNANCY (27-28 June 2016, RIGA, LATVIA)
27-28 June 2016, Riga, Latvia hosted the International WHO consultation on nutrition and pregnancy, with participation of experts in the field of maternal and child health and the WHO Collaborating Centers from Poland, Latvia, Lithuania, Estonia, Italy, the UK, Kazakhstan, Tajikistan, Uzbekistan, Kyrgyzstan, Georgia, Armenia and Moldova. The key problems of women's health and nutrition, according to speakers from different countries are the following: the growth of overweight and obesity among women, excessive weight gain during pregnancy, low rates of exclusive breastfeeding in the first ...
Толығырақ
2016 жыл | Шығарылым: 4 | Беттер: 166-172