СОВРЕМЕННОЕ ПРЕДСТАВЛЕНИЕ О МОЛЕКУЛЯРНЫХ МЕХАНИЗМАХ ДЕЙСТВИЙ МЕТФОРМИНА
Обзор посвящен анализу молекулярных механизмов действия метформина, широко применяемого во всем мире, антидиабетического средства. Кроме гипогликемического действия у метформина обнаружен ряд плейотропных эффектов, в частности противоопухолевый. <span style="border-width: 1pt; border-color: windowtext;">Эффект метформина на пролиферацию раковых клеток связан с активацией AMPK и угнетением </span><span style="border-width: 1pt; border-color: windowtext;">mTOR</span><span style="border-width: 1pt; border-color: windowtext;">, который иг...
Толығырақ
2015 жыл | Шығарылым: 2 | Беттер: 19-29
ПОПЕРЕЧНЫЕ (ОДНОМОМЕНТНЫЕ) ИССЛЕДОВАНИЯ В ЗДРАВООХРАНЕНИИ
В настоящей работе представлены основные принципы планирования, проведения и статистической обработки данных поперечных (одномоментных) исследований в здравоохранении. Приведены практические примеры расчета размера выборки и оценки связи между факторами риска с помощью онлайн-калькуляторов и пакета для обработки эпидемиологических данных Epi Info. Авторы представляют практические примеры использования поперечных исследований в литературе, а также достоинства и недостатки данного типа исследований. Настоящая статья призвана дать общие сведения о поперечных исследованиях, и не заменяет п...
Толығырақ
2015 жыл | Шығарылым: 2 | Беттер: 5-18
ХИРУРГИЧЕСКОЕ ЛЕЧЕНИЕ ВНУТРИМОЗГОВЫХ КРОВОИЗЛИЯНИЙ У БЕРЕМЕННЫХ ЖЕНЩИН
Возникновение неотложных нейрохирургических
состояний у беременных женщин является сложной мультидисциплинарной проблемой,
для решения которой требуется участие специалистов нескольких смежных
специальностей.
Толығырақ
2015 жыл | Шығарылым: 1 | Беттер: 77-80
МОДЕЛЬ УПРАВЛЕНИЯ МОТИВАЦИЕЙ МЕДИЦИНСКОГО ПЕРСОНАЛА НА ПРИМЕРЕ РЕГИОНАЛЬНОГО ОНКОЛОГИЧЕСКОГО ДИСПАНСЕРА ГОРОДА СЕМЕЙ
В статье представлена модель мотивационного управления медицинским персоналом Регионального онкологического диспансера г. Семей, на базе которого находится кафедра онкологии и радиологии медицинского университета имени д.м.н., профессора Д.Р. Мусинова и проходят обучение по программе резидентура, магистратура, Phd докторантура. Мотивация персонала освещена в свете реализации Программы развития онкологической помощи на 2012-2016 года, включая развитие ядерной медицины. Создание высокоэффективных и мотивированных команд, в том числе и в лечебно-профилактических учреждениях, позволит повысить про...
Толығырақ
2015 жыл | Шығарылым: 1 | Беттер: 70-76
СОСТОЯНИЕ КОАГУЛЯЦИОННОГО ЗВЕНА ГЕМОСТАЗА У ЖЕНЩИН ГРУППЫ РИСКА ПРИ ПОСЛЕРОДОВЫХ КРОВОТЕЧЕНИЯХ В ЗАВИСИМОСТИ ОТ ПАРИТЕТА РОДОВ
Акушерские кровотечения остаются актуальной проблемой современного акушерства и занимают ведущее место в структуре материнской смертности во многих странах мира. Немалый вклад в летальные исходы от данной патологии в Республике Казахстан вносят многорожавшие женщины. Более 2/3 кровопотерь, в том числе угрожающих жизни матери, связано с нарушениями в системе гемостаза.
Толығырақ
2015 жыл | Шығарылым: 1 | Беттер: 60-69
ТРАВМЫ В СЛЕДСТВИИ ПАДЕНИЯ У ЛИЦ ПОЖИЛОГО И СТАРЧЕСКОГО ВОЗРАСТА
2012 жыл | Шығарылым: 6 | Беттер: 74-76
СТЕНОКАРДИЯ МЕН АЯҚ ТАМЫРЛАРЫНЫҢ ОБЛИТЕРАЦИЯЛЫҚ АТЕРОСКЛЕРОЗЫ ҚАТАР ЖҮРЕТІН НАУҚАСҚА КОРАКСАНАУ ҚОЛДАНУДЫҢ НӘТИЖЕЛІЛІГІ
2012 жыл | Шығарылым: 6 | Беттер: 70-71
ҚОСАЛҚЫ ЖАРАҚАТТАРЫ БАР НАУҚАСТАРДЫҢ ТРОМБОЭМБОЛИЯЛЫҚ АСҚЫНУЛАРЫНЫҢ ҚАЗІРГІ ЗАМАНҒЫ АЛДЫН АЛУ МҮМКІНДІКТЕРІ
2012 жыл | Шығарылым: 6 | Беттер: 68-69
ӨКПЕНІҢ ІРІҢ ДЕСТРУКЦИЯСЫНА ЕМДЕУДЕ ҚОЛДАНЫЛГАН СЕГМЕНТАРЛЫҚ-СУБСЕГМЕНТАРЛЫҚ БРОНХИЯЛЫҚ АҒАШТЫҢ ФИБРОБРОНХОСКОПИЯЛЫҚ СҮРЕТІ
2012 жыл | Шығарылым: 6 | Беттер: 65-67
ORGANIZATION OF PRIMARY HEALTH CARE FOR TYPE II DIABETES PATIENTS IN SELECTED OECD COUNTRIES
In this literature review we present international experience in organization of primary health care for Type II diabetic patients in different countries at various stages of economic development.
This is a semisystematic review of literature published in English language literature. Article search was performed using the following key words: «Type II diabetes», primary health care”, “OECD” using PubMed, Medline Complete, Wiley Online Library, SpringerLink, Google scholar, eLibrary, published from 2010 to 2017 годы. Also we studied program documents of the International Diabetic ... Толығырақ
This is a semisystematic review of literature published in English language literature. Article search was performed using the following key words: «Type II diabetes», primary health care”, “OECD” using PubMed, Medline Complete, Wiley Online Library, SpringerLink, Google scholar, eLibrary, published from 2010 to 2017 годы. Also we studied program documents of the International Diabetic ... Толығырақ
2017 жыл | Шығарылым: 5 | Беттер: 88-98
ESTIMATING THE PREVALENCE OF RISK FACTORS FOR PROGRESSION OF CHRONIC KIDNEY DISEASE IN PATIENTS WITH CHRONIC GLOMERULONEPHRITIS
Introduction: effective prevention of chronic kidney disease is possible on the basis of early detection of risk factors for its development, elaboration of measures for their stratification, and searching for optimal diagnostic markers.
Aim: determination of risk factors prevalence for progression of chronic kidney disease in patients with chronic glomerulonephritis.
Materials and methods. The design of the study is a cross-sectional sociological study.116 patients undergoing treatment in nephrological department of the Hospital of nephrology, internal ... Толығырақ
Introduction: effective prevention of chronic kidney disease is possible on the basis of early detection of risk factors for its development, elaboration of measures for their stratification, and searching for optimal diagnostic markers.
Aim: determination of risk factors prevalence for progression of chronic kidney disease in patients with chronic glomerulonephritis.
Materials and methods. The design of the study is a cross-sectional sociological study.116 patients undergoing treatment in nephrological department of the Hospital of nephrology, internal ... Толығырақ
2017 жыл | Шығарылым: 5 | Беттер: 76-87
COMPARISON OF CLINICAL FEATURES OF PANIC DISORDER PATIENTS WITH AND WITHOUT FAMILY HISTORY OF PSYCHIATRIC DISORDERS
Introduction: The large goal of this study elucidates the cause of panic disorder, and medical people carry out the fundamental treatment and prevention for the disorder.
Purpose: One aim of this study was to investigate the diagnosis of psychiatric disorders (including panic disorder) in first-degree relatives of panic disorder patients. Another aim of this study was to examine the age at the onset of the first panic attack and the number of symptoms at onset in panic disorder patients in order to better understand the in fluence of family history of psychiatric disorders (i... Толығырақ
Purpose: One aim of this study was to investigate the diagnosis of psychiatric disorders (including panic disorder) in first-degree relatives of panic disorder patients. Another aim of this study was to examine the age at the onset of the first panic attack and the number of symptoms at onset in panic disorder patients in order to better understand the in fluence of family history of psychiatric disorders (i... Толығырақ
2017 жыл | Шығарылым: 5 | Беттер: 67-75
THE INFLUENCE OF PREGNANCY-ASSOCIATED PLASMA PROTEIN А (РАРР-А) ON INTRAUTERINE GROWTH RESTRICTION
Introduction: the search of methods enabling to predict fetal growth impairment is an important issue for modern obstetrics. Pregnancy-associated plasma protein А (РАРР-А) is considered to be one of the predictors of fetal chromosomal mutations. The associations between reduced РАРР-А levels in first pregnancy trimester and the development of intrauterine growth restriction (IUGR) is being extensively studied over the last years. The current normal range of РАРР-А in Kazakhstan is considered to be 0,5-2,05.
Aim: to study the associations between РАРР-А levels in first pre... Толығырақ
Aim: to study the associations between РАРР-А levels in first pre... Толығырақ
2017 жыл | Шығарылым: 5 | Беттер: 55-66
FACTORS INFLUENCING ON ADHERENCE TO ANTIHYPERTENSIVE THERAPY AT PATIENTS WITH ARTERIAL HYPERTENSION IN EAST KAZAKHSTAN
Aim of research – to analyse influence of social-economical, clinical and pharmaco-epidemiological factors to patients’s compliance on the treatment in population of East Kazakhstan.
Materials and methods: Study design – cross-sectional study. The study included 2346 patients with arterial hypertension aged 25 to 80 years, including 1281 men (54,6%) and 1065 women (45,4%). The average age is 55,2 ± 1,1 years.
Carried out estimation of compliance to medical therapy at patients with arterial hypertension. Depending on the degree of compliance, estimated patien... Толығырақ
Materials and methods: Study design – cross-sectional study. The study included 2346 patients with arterial hypertension aged 25 to 80 years, including 1281 men (54,6%) and 1065 women (45,4%). The average age is 55,2 ± 1,1 years.
Carried out estimation of compliance to medical therapy at patients with arterial hypertension. Depending on the degree of compliance, estimated patien... Толығырақ
2017 жыл | Шығарылым: 5 | Беттер: 42-54