ФОРМИРОВАНИЕ ОЧАГОВ Р53 СВЯЗАННОГО БЕЛКА 1 В ОПУХОЛЯХ ЩИТОВИДНОЙ ЖЕЛЕЗЫ: АКТИВАЦИЯ ГЕНЕТИЧЕСКОЙ НЕСТАБИЛЬНОСТИ В ТЕЧЕНИИ КАНЦЕРОГЕНЕЗА ЩИТОВИДНОЙ ЖЕЛЕЗЫ. ОБЗОР ЛИТЕРАТУРЫ
Введение: К настоящему времени достигнуты большие успехи в изучении молекулярно–клеточных механизмов канцерогенеза, установлении роли онкогенов и антионкогенов в развитии опухолей различной локализации, в том числе и РЩЖ. Подавляющее число доброкачественных и злокачественных опухолей щитовидной железы развивается из фолликулярного эпителия, которые имеют разную степень дифференцировки, разные морфогенетические и биохимические особенности, клиническое течение и прогноз.
Цель: проведение поиска научной информации по активации генетической нестабильности в течений канцерогенеза щитовидной ... Толығырақ
Цель: проведение поиска научной информации по активации генетической нестабильности в течений канцерогенеза щитовидной ... Толығырақ
2019 жыл | Шығарылым: 2 | Беттер: 25-37
ОРГАНИЗАЦИОННЫЕ ОСНОВЫ СКРИНИНГА КОЛОРЕКТАЛЬНОГО РАКА В МИРОВОЙ МЕДИЦИНСКОЙ ПРАКТИКЕ. ОБЗОР ЛИТЕРАТУРЫ
Актуальность. Рак ободочной и прямой кишки (колоректальный) является третьим по распространенности раком в мире. Он поддается скринингу, так как скрининговое исследование может быть осуществлено на предраковых, латентных, ранних и излечимых стадиях. При скрининге колоректального рака могут использоваться прямые или непрямые методы, применяемые произвольно или в структуре организованных программ. Большинство случаев колоректального рака диагностируется в возрасте старше 60 лет. Большинство программ скрининга относятся к лицам в возрасте 50-75 лет.
Цель обзора – Анализ подходов и р... Толығырақ
Цель обзора – Анализ подходов и р... Толығырақ
2019 жыл | Шығарылым: 2 | Беттер: 13-24
MODERN TENDENCY IN TREATMENT OF PATIENTS WITH SEVERE TRAUMATIC BRAIN INJURY. LITERARY REVIEW
Relevance: Carrying out of intensive therapy at severe traumatic brain injury is a complex of measures aimed on saving of the brain tissues and maintaining its functions. To achieve this goal, it is necessary to do timely diagnostics and monitoring of critical parameters - intracranial pressure and cerebral perfusion pressure; pathogenetically based therapy and nutritional support for critically ill patients.
Aim: The goal of this review was to find evidences of admissibility of use for such methods as control of cerebral perfusion pressure and intracranial pressure, anti-edematous thera... Толығырақ
Aim: The goal of this review was to find evidences of admissibility of use for such methods as control of cerebral perfusion pressure and intracranial pressure, anti-edematous thera... Толығырақ
2019 жыл | Шығарылым: 2 | Беттер: 5-12
ЛЕЧЕНИЕ ПОПЕРЕЧНОГО ПЛОСКОСТОПИЯ С HALLUX VALGUS ПРИ I и II ТИПЕ РАСПЛАСТАННОСТИ СТОПЫ
Введение. Статическая деформация переднего отдела стопы составляет до 80% среди ортопедической патологии стопы у взрослых. Патология вызывает значительное нарушение биомеханики всей нижней конечности, сопровождаясь болью в переднем отделе стопы, затруднение в подборе и ношении обуви, значительно снижает трудоспособность и качество жизни пациента. В связи с этим разработка технологии лечения статической деформации переднего отдела стопы, предусматривающей устранение Halluxvalgus, metatarsusprimavarus и плантарную девиацию центральных лучей стопы остается не полностью решенной и актуальной п...
Толығырақ
2019 жыл | Шығарылым: 1 | Беттер: 80-90
АНТИБИОТИКОРЕЗИСТЕНТНОСТЬ ШИГЕЛЛ НА СОВРЕМЕННОМ ЭТАПЕ
Введение. Одна из больших проблем практического здравоохранения на современном этапе – это рост антибиотикорезистентности шигелл к тем антибактериальным препаратам, которые широко сегодня используются в их лечении.
Цель исследования: изучить чувствительность штаммов Shigella spp., выделенных из кишечника больных острой дизентерией, к широко используемым в клинической практике антимикробным препаратам.
Материалы и методы. Проведен ретроспективный анализ 236 медицинских карт пациентов с диагнозом острой дизентерии, пролеченных на базе Городской инфекционной больница г. Астана за пе... Толығырақ
Цель исследования: изучить чувствительность штаммов Shigella spp., выделенных из кишечника больных острой дизентерией, к широко используемым в клинической практике антимикробным препаратам.
Материалы и методы. Проведен ретроспективный анализ 236 медицинских карт пациентов с диагнозом острой дизентерии, пролеченных на базе Городской инфекционной больница г. Астана за пе... Толығырақ
2019 жыл | Шығарылым: 1 | Беттер: 74-79
COMPARATIVE EVALUATION OF BLOOD COLLECTION TUBES AND EXTRACTION METHODS FOR CIRCULATING TUMOR DNA
2025 жыл | Шығарылым: 6 | Беттер: 7-13
INFLUENCE OF SEX HORMONE-BINDING GLOBULIN (SHBG) ON THE LEVEL OF FREE TESTOSTERONE FRACTION IN OLDER OVERWEIGHT MEN
2025 жыл | Шығарылым: 6 | Беттер: 14-20
GENETIC VARIANTS IN LIPID-ASSOCIATED GENES IN THE KAZAKHSTANI COHORT WITH ATHEROSCLEROSIS AND HYPERTRIGLYCERIDEMIA
2025 жыл | Шығарылым: 5 | Беттер: 7-15
CLONAL HEMATOPOIESIS WITH INDETERMINATE POTENTIAL IN TET2 AND DNMT3A AMONG KAZAKHSTANI INDIVIDUALS WITH ATHEROSCLEROTIC DISEASE
2025 жыл | Шығарылым: 5 | Беттер: 16-23
COMMENTS ON 2017 EUROPEAN GUIDELINES FOR THE MANAGEMENT OF ACUTE MYOCARDIAL INFARCTION IN PATIENTS PRESENTING WITH ST-SEGMENT ELEVATION
Updated European guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation were published in 2017. All the new and changed recommendations was analysed in order to investigate the possibility of their application in our country.
Objective: to reveal essential evidence-based updated points of the 2017 guidelines that can be implemented in the settings of Kazakhstan health care system.
Materials and methods: the first stage of the review was performing a comparative analysis of old (2012) and updated versions ... Толығырақ
Objective: to reveal essential evidence-based updated points of the 2017 guidelines that can be implemented in the settings of Kazakhstan health care system.
Materials and methods: the first stage of the review was performing a comparative analysis of old (2012) and updated versions ... Толығырақ
2017 жыл | Шығарылым: 5 | Беттер: 99-112
ORGANIZATION OF PRIMARY HEALTH CARE FOR TYPE II DIABETES PATIENTS IN SELECTED OECD COUNTRIES
In this literature review we present international experience in organization of primary health care for Type II diabetic patients in different countries at various stages of economic development.
This is a semisystematic review of literature published in English language literature. Article search was performed using the following key words: «Type II diabetes», primary health care”, “OECD” using PubMed, Medline Complete, Wiley Online Library, SpringerLink, Google scholar, eLibrary, published from 2010 to 2017 годы. Also we studied program documents of the International Diabetic ... Толығырақ
This is a semisystematic review of literature published in English language literature. Article search was performed using the following key words: «Type II diabetes», primary health care”, “OECD” using PubMed, Medline Complete, Wiley Online Library, SpringerLink, Google scholar, eLibrary, published from 2010 to 2017 годы. Also we studied program documents of the International Diabetic ... Толығырақ
2017 жыл | Шығарылым: 5 | Беттер: 88-98
ESTIMATING THE PREVALENCE OF RISK FACTORS FOR PROGRESSION OF CHRONIC KIDNEY DISEASE IN PATIENTS WITH CHRONIC GLOMERULONEPHRITIS
Introduction: effective prevention of chronic kidney disease is possible on the basis of early detection of risk factors for its development, elaboration of measures for their stratification, and searching for optimal diagnostic markers.
Aim: determination of risk factors prevalence for progression of chronic kidney disease in patients with chronic glomerulonephritis.
Materials and methods. The design of the study is a cross-sectional sociological study.116 patients undergoing treatment in nephrological department of the Hospital of nephrology, internal ... Толығырақ
Introduction: effective prevention of chronic kidney disease is possible on the basis of early detection of risk factors for its development, elaboration of measures for their stratification, and searching for optimal diagnostic markers.
Aim: determination of risk factors prevalence for progression of chronic kidney disease in patients with chronic glomerulonephritis.
Materials and methods. The design of the study is a cross-sectional sociological study.116 patients undergoing treatment in nephrological department of the Hospital of nephrology, internal ... Толығырақ
2017 жыл | Шығарылым: 5 | Беттер: 76-87
COMPARISON OF CLINICAL FEATURES OF PANIC DISORDER PATIENTS WITH AND WITHOUT FAMILY HISTORY OF PSYCHIATRIC DISORDERS
Introduction: The large goal of this study elucidates the cause of panic disorder, and medical people carry out the fundamental treatment and prevention for the disorder.
Purpose: One aim of this study was to investigate the diagnosis of psychiatric disorders (including panic disorder) in first-degree relatives of panic disorder patients. Another aim of this study was to examine the age at the onset of the first panic attack and the number of symptoms at onset in panic disorder patients in order to better understand the in fluence of family history of psychiatric disorders (i... Толығырақ
Purpose: One aim of this study was to investigate the diagnosis of psychiatric disorders (including panic disorder) in first-degree relatives of panic disorder patients. Another aim of this study was to examine the age at the onset of the first panic attack and the number of symptoms at onset in panic disorder patients in order to better understand the in fluence of family history of psychiatric disorders (i... Толығырақ
2017 жыл | Шығарылым: 5 | Беттер: 67-75
THE INFLUENCE OF PREGNANCY-ASSOCIATED PLASMA PROTEIN А (РАРР-А) ON INTRAUTERINE GROWTH RESTRICTION
Introduction: the search of methods enabling to predict fetal growth impairment is an important issue for modern obstetrics. Pregnancy-associated plasma protein А (РАРР-А) is considered to be one of the predictors of fetal chromosomal mutations. The associations between reduced РАРР-А levels in first pregnancy trimester and the development of intrauterine growth restriction (IUGR) is being extensively studied over the last years. The current normal range of РАРР-А in Kazakhstan is considered to be 0,5-2,05.
Aim: to study the associations between РАРР-А levels in first pre... Толығырақ
Aim: to study the associations between РАРР-А levels in first pre... Толығырақ
2017 жыл | Шығарылым: 5 | Беттер: 55-66