СОВРЕМЕННОЕ ПРЕДСТАВЛЕНИЕ О МОЛЕКУЛЯРНЫХ МЕХАНИЗМАХ ДЕЙСТВИЙ МЕТФОРМИНА
Обзор посвящен анализу молекулярных механизмов действия метформина, широко применяемого во всем мире, антидиабетического средства. Кроме гипогликемического действия у метформина обнаружен ряд плейотропных эффектов, в частности противоопухолевый. <span style="border-width: 1pt; border-color: windowtext;">Эффект метформина на пролиферацию раковых клеток связан с активацией AMPK и угнетением </span><span style="border-width: 1pt; border-color: windowtext;">mTOR</span><span style="border-width: 1pt; border-color: windowtext;">, который иг...
Толығырақ
2015 жыл | Шығарылым: 2 | Беттер: 19-29
ПОПЕРЕЧНЫЕ (ОДНОМОМЕНТНЫЕ) ИССЛЕДОВАНИЯ В ЗДРАВООХРАНЕНИИ
В настоящей работе представлены основные принципы планирования, проведения и статистической обработки данных поперечных (одномоментных) исследований в здравоохранении. Приведены практические примеры расчета размера выборки и оценки связи между факторами риска с помощью онлайн-калькуляторов и пакета для обработки эпидемиологических данных Epi Info. Авторы представляют практические примеры использования поперечных исследований в литературе, а также достоинства и недостатки данного типа исследований. Настоящая статья призвана дать общие сведения о поперечных исследованиях, и не заменяет п...
Толығырақ
2015 жыл | Шығарылым: 2 | Беттер: 5-18
ХИРУРГИЧЕСКОЕ ЛЕЧЕНИЕ ВНУТРИМОЗГОВЫХ КРОВОИЗЛИЯНИЙ У БЕРЕМЕННЫХ ЖЕНЩИН
Возникновение неотложных нейрохирургических
состояний у беременных женщин является сложной мультидисциплинарной проблемой,
для решения которой требуется участие специалистов нескольких смежных
специальностей.
Толығырақ
2015 жыл | Шығарылым: 1 | Беттер: 77-80
МОДЕЛЬ УПРАВЛЕНИЯ МОТИВАЦИЕЙ МЕДИЦИНСКОГО ПЕРСОНАЛА НА ПРИМЕРЕ РЕГИОНАЛЬНОГО ОНКОЛОГИЧЕСКОГО ДИСПАНСЕРА ГОРОДА СЕМЕЙ
В статье представлена модель мотивационного управления медицинским персоналом Регионального онкологического диспансера г. Семей, на базе которого находится кафедра онкологии и радиологии медицинского университета имени д.м.н., профессора Д.Р. Мусинова и проходят обучение по программе резидентура, магистратура, Phd докторантура. Мотивация персонала освещена в свете реализации Программы развития онкологической помощи на 2012-2016 года, включая развитие ядерной медицины. Создание высокоэффективных и мотивированных команд, в том числе и в лечебно-профилактических учреждениях, позволит повысить про...
Толығырақ
2015 жыл | Шығарылым: 1 | Беттер: 70-76
СОСТОЯНИЕ КОАГУЛЯЦИОННОГО ЗВЕНА ГЕМОСТАЗА У ЖЕНЩИН ГРУППЫ РИСКА ПРИ ПОСЛЕРОДОВЫХ КРОВОТЕЧЕНИЯХ В ЗАВИСИМОСТИ ОТ ПАРИТЕТА РОДОВ
Акушерские кровотечения остаются актуальной проблемой современного акушерства и занимают ведущее место в структуре материнской смертности во многих странах мира. Немалый вклад в летальные исходы от данной патологии в Республике Казахстан вносят многорожавшие женщины. Более 2/3 кровопотерь, в том числе угрожающих жизни матери, связано с нарушениями в системе гемостаза.
Толығырақ
2015 жыл | Шығарылым: 1 | Беттер: 60-69
METHODOLOGICAL STUDY VALIDATION OF THE INSTRUMENT «ORGANIZATIONAL ASPECTS OF URO-ANDROLOGICAL CARE» FOR USE BY HEALTHCARE ORGANIZATION SPECIALISTS
2025 жыл | Шығарылым: 6 | Беттер: 91-100
FACTORS OF LIMITED DIAGNOSIS OF PHARAMACORESISTANT EPILEPSY
2025 жыл | Шығарылым: 6 | Беттер: 101-108
PSYCHOLOGICAL AND SOCIAL ASPECTS OF SYNTHETIC PSYCHOACTIVE SUBSTANCE USE AMONG INDIVIDUALS WITH BORDERLINE MENTAL DISORDERS: A COMPARATIVE ANALYSIS
2025 жыл | Шығарылым: 6 | Беттер: 109-117
ASSESSING RETINOBLASTOMA AWARENESS ACROSS PRIMARY HEALTH CARE PHYSICIANS
2025 жыл | Шығарылым: 6 | Беттер: 118-125
MPOX: FROM EPIDEMIOLOGICAL TRENDS TO MODERN IMMUNOPROPHYLAXIS STRATEGIES. LITERATURE REVIEW
2025 жыл | Шығарылым: 6 | Беттер: 135-148
FOREIGN AND NATIVE EXPERIENCE OF CARE AGAINST TUBERCULOSIS FOR HIV – INFECTED PATIENTS. Review.
Introduction. Co - infection of tuberculosis / human immunodeficiency virus (TB/HIV) is not only one of the most common combinations of dual infection among people living with HIV, but also the most dangerous for the patient and for society as a whole.
The aim of our review was to study the organization of TB care to patients with HIV infection in Kazakhstan and foreign countries.
Research methods. The study included full-text publications in English and Russian languages, which were devoted to the study of the organization of TB care to people livi... Толығырақ
The aim of our review was to study the organization of TB care to patients with HIV infection in Kazakhstan and foreign countries.
Research methods. The study included full-text publications in English and Russian languages, which were devoted to the study of the organization of TB care to people livi... Толығырақ
2017 жыл | Шығарылым: 1 | Беттер: 166-179
AWARENESS AND TRUST ON VACCINATION OF THE WOMEN LIVING IN EAST KAZAKHSTAN REGION ON THE RESULTS OF THE SURVEY
Background: Questions of trust in vaccination becomes a relevant view of the increase cases of refusal of vaccination in the last time, and the knowledge about the sources of information on vaccination definitely can impact further to health education work in this direction.
Objectives: To study the sources of information about vaccination and the credibility of these sources among the population of East Kazakhstan Regon.
Methods: Questionnaire is designed for parents with children under 3 years living in Semey and EKR. The questionnaire included 36 blocks of question... Толығырақ
Objectives: To study the sources of information about vaccination and the credibility of these sources among the population of East Kazakhstan Regon.
Methods: Questionnaire is designed for parents with children under 3 years living in Semey and EKR. The questionnaire included 36 blocks of question... Толығырақ
2017 жыл | Шығарылым: 1 | Беттер: 156-165
SCREENING OF DIABETIC RETINOPATHY IN A POPULATION OF PAVLODAR REGION
Introduction: diabetic retinopathy is a specific diabetes-induced vascular complication associated with the stable retinal malfunctioning. This is the commonest cause of blindness in the labour-active part of population in developed nations being responsible for 80-90% of all diabetes-related ocular disability.
Aim: to screen the population of patients with diabetes followed by the State Diabetes Register in order to elucidate the prevalence and the structure of diabetic retinopathy.
Materials and methods: this was a cross-sectional study. Overall, we examined 310... Толығырақ
Aim: to screen the population of patients with diabetes followed by the State Diabetes Register in order to elucidate the prevalence and the structure of diabetic retinopathy.
Materials and methods: this was a cross-sectional study. Overall, we examined 310... Толығырақ
2017 жыл | Шығарылым: 1 | Беттер: 146-155
MEDICAL AND SOCIAL PORTRAIT OF A PREGNANT WOMAN FROM SEMEY AND AWARENESS OF PREGNANT WOMEN ABOUT THE SOCIAL AND PSYCHOLOGICAL SERVICES
Background: The course of pregnancy and emerging type of motherhood can be affected by family history of the expectant mother, as well as socio-cultural factors, such as position of women in society and social significance of motherhood.
The aim of the study is to create a socio-medical portrait of a pregnant woman from Semey and to determine the awareness of women about the available social and psychological services.
Methods: Design - A cross-sectional study. Random sample (n = 350 women). 354 pregnant women who are registered in Semey primary health care in... Толығырақ
The aim of the study is to create a socio-medical portrait of a pregnant woman from Semey and to determine the awareness of women about the available social and psychological services.
Methods: Design - A cross-sectional study. Random sample (n = 350 women). 354 pregnant women who are registered in Semey primary health care in... Толығырақ
2017 жыл | Шығарылым: 1 | Беттер: 133-145
UPTAKE BARRIERS TO THE TREATMENT OF PRECANCEROUS CERVICAL DISEASES
Background. The malignant cervical tumors are the second leading cause of female mortality in the Republic of Kazakhstan. Currently, there is a growth of untreated precancerous cervical diseases which have a potential to develop into cervical cancer. In this connection, the question arises what barriers exist to the treatment of precancerous cervical diseases.
Objective: To identify uptake barriers to the treatment of precancerous cervical diseases.
Materials and methods. A cross-sectional study with random sampling strategy. Sampling - 404 women of childbearing age, ... Толығырақ
Objective: To identify uptake barriers to the treatment of precancerous cervical diseases.
Materials and methods. A cross-sectional study with random sampling strategy. Sampling - 404 women of childbearing age, ... Толығырақ
2017 жыл | Шығарылым: 1 | Беттер: 122-132