MUTATIONS IN CARDIAC ION CHANNEL GENES IN KAZAKHSTANI PATIENTS WITH LONG QT SYNDROME
2024 year | Issue: 1 | Pages: 7-14
КЛОНАЛЬНЫЙ ГЕМОПОЭЗ С НЕОПРЕДЕЛЕННЫМ ПОТЕНЦИАЛОМ И РИСК РАЗВИТИЯ ИШЕМИЧЕСКОЙ БОЛЕЗНИ СЕРДЦА
2023 year | Issue: 6 | Pages: 161-170
THROMBOSIS AND BLEEDING COMPLICATIONS AFTER IMPLANTATION OF MECHANICAL CIRCULATORY SUPPORT DEVICES: THE REASONS AND MECHANISMS OF DEVELOPMENT, GENOME-GUIDED CORRECTION. REVIEW.
2023 year | Issue: 2 | Pages: 166-174
ESTIMATION OF THE WARFARIN DOSE IN HEART FAILURE PATIENTS WITH IMPLANTED MECHANICAL CIRCULATORY SUPPORT DEVICE
2023 year | Issue: 1 | Pages: 59-66
БЕЛГІСІЗ ПОТЕНЦИАЛЫ КЛОНДЫ ГЕМОПОЭЗ ЖӘНЕ ЖҮРЕКТІҢ ИШЕМИЯЛЫҚ АУРУЫНЫҢ ДАМУ ҚАУПІ
2023 year | Issue: 6 | Pages: 161-170
МЕХАНИКАЛЫҚ ҚАН АЙНАЛЫМЫН ҚОЛДАЙТЫН ҚҰРЫЛҒЫСЫННЫҢ ИМПЛАНТАЦИЯЛАУДАН КЕЙІНГІ ТРОМБТЫҢ ТҮЗІЛУ ЖӘНЕ ҚАН КЕТУДІҢ АСҚЫНУЛАРЫ: ДАМУ СЕБЕПТЕРІ МЕН МЕХАНИЗМДЕРІ, ГЕНОМ – НЕГІЗДЕЛГЕН ЕМ. ӘДЕБИЕТКЕ ШОЛУ.
2023 year | Issue: 2 | Pages: 166-174
МЕХАНИКАЛЫҚ ҚАН АЙНАЛЫМЫН ҚОЛДАЙТЫН ҚҰРЫЛҒЫСЫ ИМПЛАНТАЦИЯЛАНҒАН ЖҮРЕК ЖЕТКІЛІКСІЗДІГІ БАР НАУҚАСТАРДА ВАРФАРИН ДОЗАСЫН ЕСЕПТЕУ
2023 year | Issue: 1 | Pages: 59-66
ҰЗАРТЫЛҒАН QT СИНДРОМЫ БАР ҚАЗАҚСТАНДЫҚ ПАЦИЕНТТЕРДЕГІ ЖҮРЕКТІҢ ИОНДЫҚ КАНАЛ ГЕНДЕРІНДЕГІ МУТАЦИЯЛАРЫ
2024 year | Issue: 1 | Pages: 7-14
ЖҮРЕК АРИТМИЯСЫ БАР НАУҚАСТАРДАҒЫ КАЛИЙ КАНАЛЫ ГЕНДЕРІНДЕГІ МУТАЦИЯЛАР. ӘДЕБИЕТТІК ШОЛУ
2022 year | Issue: 3 | Pages: 117-126
MOLECULAR CHARACTERIZATION OF MULTIDRUG RESISTANT M.TUBERCULOSIS STRAINS DISTRIBUTED IN THE TERRITORY OF KAZAKHSTAN
2019 year | Issue: 5 | Pages: 45-52.
RNA SEQUENCING OF SQUAMOUS ESOPHAGEAL CANCER: FROM THE COLLECTION OF THE BIOMATERIAL UNTIL SEQUENCING ON HISEQ2000
The squamous esophageal cancer is a disease which is highly frequent in Kazakhstan, the frequency of the disease is 10,1:100 000. In the mortality structure esophageal cancer takes place among men the 5th place, among women the 9th place in the Republic of Kazakhstan. The molecular mechanisms which contribute to the initiation and progression of the cancer pathology are not investigated enough. Nevertheless, the lack of the sensitive and specific biomarkers for the diagnosis of the cancer diseases, underlines about the necessity of the additional research works to study about the development o...
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2016 year | Issue: 5 | Pages: 53-63
DEVELOPMENT OF HALOPLEX PANEL AND PREPARATION OF DNA LIBRARIES FOR TARGETED SEQUENCING OF CARDIAC ARRHYTHMIAS
Method of preparation of custom HaloPlex cardiogenetic panel (Agilent Technologies) and method of preparation of DNA libraries for targeted sequencing of 96 genes associated with cardiac arrhythmias were described in details in this article. SureDesign Online Design software (Agilent Technologies) was used to create the HaloPlex panel. Final design was developed for Illumina platform using Human Genome version 19, GRCh 37. 19958 amplicons were generated by the program, 99,46% of all target regions were covered successfully. DNA libraries were prepared for 48 samples using t...
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2016 year | Issue: 5 | Pages: 43-52
DETERMINATION OF GENETIC VARIANTS ASSOCIATED WITH HYPERTENSION, OBESITY AND DIABETES IN KAZAKH POPULATION TO STUDY INTERACTION OF GENETIC VARIANTS AND METABOLOME
In this work genetic variants associated with hypertension, obesity and diabetes were characterized, and genomic data of 60 samples were compared using Т-HOD (The Text-mined Hypertension, Obesity and Diabetes candidate gene database (T-HOD) international database.
Genetic variants extracted from whole genomes and exomes, and associated with hypertension, obesity and diabetes based on PolyPhen2 and SIFT algorithmic predictors of mutation pathogenicity were analyzed. Seven genetic variants were detected in GHRL (rs4684677), MTHFR (rs1801133), OPRM1 (rs17999... More
Genetic variants extracted from whole genomes and exomes, and associated with hypertension, obesity and diabetes based on PolyPhen2 and SIFT algorithmic predictors of mutation pathogenicity were analyzed. Seven genetic variants were detected in GHRL (rs4684677), MTHFR (rs1801133), OPRM1 (rs17999... More
2016 year | Issue: 5 | Pages: 30-42