МЕТОДИКА ОПРЕДЕЛЕНИЯ ЛОКОМОТОРНОЙ АКТИВНОСТИ КРЫС
Введение: изучение локомоторной активности крыс широко применяется в экспериментальных научных исследованиях во всем мире. Это связано с тем, что оно считается неотъемлемой частью клинических испытаний. С помощью определения подвижности мы можем оценить воздействие определенного фармакологического препарата, влияние окружающей среды на психо-эмоциональное состояние живого организма. В статье представлены литературные данные о различных методиках определения локомоторной активности млекопитающих, а также наша личная разработка по изучению подвижности крыс.
Цель: разработать метод для кру... Толығырақ
Цель: разработать метод для кру... Толығырақ
2016 жыл | Шығарылым: 6 | Беттер: 89-97
СОСТОЯНИЕ СЛИЗИСТОЙ ОБОЛОЧКИ ПОЛОСТИ РТА НА ЭТАПАХ ОРТОПЕДИЧЕСКОГО ЛЕЧЕНИЯ
Введение. Качество ортопедического лечения зависит от скорости адаптации слизистой оболочки протезного ложа и пародонта к ортопедическим конструкциям.
Целью данного исследования является разработка способа обнаружения воспаления слизистой оболочки полости рта на этапах ортопедического лечения путем усовершенствования известного. Также необходима объективизация процесса выявления воспаления за счет графической визуализации полученных результатов и обеспечение повышения степени информативности исследования и эффективности ортопедического лечения на всех этапах подготовки полости рта к прот... Толығырақ
Целью данного исследования является разработка способа обнаружения воспаления слизистой оболочки полости рта на этапах ортопедического лечения путем усовершенствования известного. Также необходима объективизация процесса выявления воспаления за счет графической визуализации полученных результатов и обеспечение повышения степени информативности исследования и эффективности ортопедического лечения на всех этапах подготовки полости рта к прот... Толығырақ
2016 жыл | Шығарылым: 6 | Беттер: 62-72
COMPARATIVE ESTIMATION OF MORBIDITY RATE AND DEGREE OF SKIN LESIONS DURING HYPOFRACTIONATED AND TRADITIONAL RADIOTHERAPY OF BREAST CANCER
Background: Radiation therapy is a necessary step for the integrated treatment of breast cancer. The traditional scheme of treatment is the use of 2 Gray in 25 fractions to the total focal dose of 50 Gy. However, like any other treatment method, radiation therapy provides a variety of side effects on normal tissue in the irradiated field. To solve this problem it is necessary to develop suitable treatment regimens to achieve better local control with minimal risk on the normal tissues.
A variety of hypofractionated radiotherapy schedules has been proposed after surgery in the attempt to ... Толығырақ
A variety of hypofractionated radiotherapy schedules has been proposed after surgery in the attempt to ... Толығырақ
2016 жыл | Шығарылым: 6 | Беттер: 40-49
АНАЛИЗ НОМИНАЛЬНЫХ И РАНГОВЫХ ПЕРЕМЕННЫХ ДАННЫХ С ИСПОЛЬЗОВАНИЕМ ПРОГРАММНОГО ОБЕСПЕЧЕНИЯ STATISTICA И SPSS
В настоящей работе представлены общие сведения о выполнении статистического анализа данных, описываемых номинальными и ранговыми переменными, с использованием программного обеспечения Statistica 10 и SPSS 20. Рассматриваются критерии хи-квадрат Пирсона, поправка Йейтса, точный критерий Фишера, а также батарея статистических критериев для анализа ранговых переменных. Настоящая статья призвана дать общие сведения об анализе качественных данных, и не заменяет прочтения специализированной литературы по статистике и клинической эпидемиологии
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2016 жыл | Шығарылым: 6 | Беттер: 5-39
ОТЧЕТ ОБ УЧАСТИИ КАЗАХСТАНСКОЙ ДЕЛЕГАЦИИ В УЧЕБНОМ КУРСЕ ПО ЛЕЧЕНИЮ И РЕАБИЛИТАЦИИ НАРКОЗАВИСИМЫХ ДЛЯ ЗАИНТЕРЕСОВАННЫХ ОФИЦИАЛЬНЫХ ЛИЦ (ТАИЛАНД)
2015 жыл | Шығарылым: 5 | Беттер: 95-97
ШАШЫРАНДЫ СКЛЕРОЗБЕН НАУҚАСТАРДА ДЖОН КАННИНГЕМ ВИРУСЫНА ҚАРСЫ АНТИДЕНЕЛЕРДІҢ ТАРАЛУЫН АНЫҚТАУ – ОСЫ ДЕРТ КЕЗІНДЕГІ ҮДЕМЕЛІ МУЛЬТИФОКАЛЬДЫ ЛЕЙКОЭНЦЕФАЛОПАТИЯ ҚАУІП –ҚАТЕРІНІҢ СТРАТИФИКАЦИЯСЫ РЕТІНДЕ
2020 жыл | Шығарылым: 1 | Беттер: 64-71
ЖЕДЕЛ КОРОНАРЛЫҚ СИНДРОМ ДИАГНОЗЫ БАР ПАЦИЕНТТЕРДІ РЕТРОСПЕКТИВТІ БАҒАЛАУ
2020 жыл | Шығарылым: 1 | Беттер: 58-63
ҚАЗАҚСТАНДАҒЫ ЖЕКЕ АДАМДАРДЫҢ ІШЕК МИКРОБТЫҚ ҚАУЫМДАСТЫҒЫН МЕТАГЕНОМИКАЛЫҚ ТАЛДАУ
2020 жыл | Шығарылым: 1 | Беттер: 48-57
АЛЛЕРГИЯЛЫҚ РИНИТІ БАР ЕМДЕЛУШІЛЕРДЕ ЭОЗИНОФИЛЬДІ КАТИОНДЫ АҚУЫЗ
2020 жыл | Шығарылым: 1 | Беттер: 39-47
МЕДИЦИНАЛЫҚ БІЛІМДІ БАСҚАРУДЫҢ ӘДІСТЕРІН ЖЕТІЛДІРУ. ӘДЕБИЕТТІ ШОЛУ
2020 жыл | Шығарылым: 1 | Беттер: 27-38
DEVELOPMENT OF HALOPLEX PANEL AND PREPARATION OF DNA LIBRARIES FOR TARGETED SEQUENCING OF CARDIAC ARRHYTHMIAS
Method of preparation of custom HaloPlex cardiogenetic panel (Agilent Technologies) and method of preparation of DNA libraries for targeted sequencing of 96 genes associated with cardiac arrhythmias were described in details in this article. SureDesign Online Design software (Agilent Technologies) was used to create the HaloPlex panel. Final design was developed for Illumina platform using Human Genome version 19, GRCh 37. 19958 amplicons were generated by the program, 99,46% of all target regions were covered successfully. DNA libraries were prepared for 48 samples using t...
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2016 жыл | Шығарылым: 5 | Беттер: 43-52
DETERMINATION OF GENETIC VARIANTS ASSOCIATED WITH HYPERTENSION, OBESITY AND DIABETES IN KAZAKH POPULATION TO STUDY INTERACTION OF GENETIC VARIANTS AND METABOLOME
In this work genetic variants associated with hypertension, obesity and diabetes were characterized, and genomic data of 60 samples were compared using Т-HOD (The Text-mined Hypertension, Obesity and Diabetes candidate gene database (T-HOD) international database.
Genetic variants extracted from whole genomes and exomes, and associated with hypertension, obesity and diabetes based on PolyPhen2 and SIFT algorithmic predictors of mutation pathogenicity were analyzed. Seven genetic variants were detected in GHRL (rs4684677), MTHFR (rs1801133), OPRM1 (rs17999... Толығырақ
Genetic variants extracted from whole genomes and exomes, and associated with hypertension, obesity and diabetes based on PolyPhen2 and SIFT algorithmic predictors of mutation pathogenicity were analyzed. Seven genetic variants were detected in GHRL (rs4684677), MTHFR (rs1801133), OPRM1 (rs17999... Толығырақ
2016 жыл | Шығарылым: 5 | Беттер: 30-42
REPORT ABOUT THE CONFERENCE: THE INTERNATIONAL WОRLD HEALTH ORGANIZATION CONSULTATION ON NUTRITION AND PREGNANCY (27-28 June 2016, RIGA, LATVIA)
27-28 June 2016, Riga, Latvia hosted the International WHO consultation on nutrition and pregnancy, with participation of experts in the field of maternal and child health and the WHO Collaborating Centers from Poland, Latvia, Lithuania, Estonia, Italy, the UK, Kazakhstan, Tajikistan, Uzbekistan, Kyrgyzstan, Georgia, Armenia and Moldova. The key problems of women's health and nutrition, according to speakers from different countries are the following: the growth of overweight and obesity among women, excessive weight gain during pregnancy, low rates of exclusive breastfeeding in the first ...
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2016 жыл | Шығарылым: 4 | Беттер: 166-172
MODERN LAVAGE OF THE GASTROINTESTINAL TRACT FROM THE PERSPECTIVE OF THE QUALITY OF DIAGNOSIS AND TREATMENT IN ENDOSCOPIC, BARIATRIC SURGERY (LITERATURE REVIEW)
Introduction. The issue of quality lavage for the gastrointestinal tract before an abdominal surgery and endoscopic examination is of paramount significance, especially in patients with visceral obesity.
The aim of the study is to study historical aspects of intestinal cleansing, identify optimal ways to lavage and define its tolerability by patients.
Research methods. The review examines the effectiveness of different lavage techniques and patients’ preparation before surgeries and endoscopic examinations. The analysis of 77 sources relevant to the results of the study is also inc... Толығырақ
The aim of the study is to study historical aspects of intestinal cleansing, identify optimal ways to lavage and define its tolerability by patients.
Research methods. The review examines the effectiveness of different lavage techniques and patients’ preparation before surgeries and endoscopic examinations. The analysis of 77 sources relevant to the results of the study is also inc... Толығырақ
2016 жыл | Шығарылым: 4 | Беттер: 145-165
HYPERHOMOCYSTEINEMIA AS A RISK FACTOR OF CARDIOVASCULAR DISEASES
Cardiovascular diseases are the leading cause of death. In this regard, the importance of the prevention problem increases, which is aimed at the identification and elimination of risk factors, which include elevated levels of homocysteine in the blood.
In recent years, actively studying the possibility of the use of B vitamins in vascular and neurodegenerative diseases. One of the main factors of hyperhomocysteinemia is the deficiency of vitamins B6, B12, B9 resulting from the features of the diet and impaired absorption. It was found that the use of preparations of B vitamins can reduc... Толығырақ
In recent years, actively studying the possibility of the use of B vitamins in vascular and neurodegenerative diseases. One of the main factors of hyperhomocysteinemia is the deficiency of vitamins B6, B12, B9 resulting from the features of the diet and impaired absorption. It was found that the use of preparations of B vitamins can reduc... Толығырақ
2016 жыл | Шығарылым: 4 | Беттер: 129-144